ID   FUS_NPVOP               Reviewed;         509 AA.
AC   P13625;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Major envelope glycoprotein;
DE   AltName: Full=gp64;
DE   Flags: Precursor;
GN   Name=GP64; Synonyms=P64; ORFNames=ORF126;
OS   Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=262177;
OH   NCBI_TaxID=33414; Orgyia pseudotsugata (Douglas-fir tussock moth).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2658304; DOI=10.1016/0042-6822(89)90445-5;
RA   Blissard G.W., Rohrmann G.F.;
RT   "Location, sequence, transcriptional mapping, and temporal expression of
RT   the gp64 envelope glycoprotein gene of the Orgyia pseudotsugata multicapsid
RT   nuclear polyhedrosis virus.";
RL   Virology 170:537-555(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9126251; DOI=10.1006/viro.1997.8448;
RA   Ahrens C.H., Russell R.R., Funk C.J., Evans J., Harwood S., Rohrmann G.F.;
RT   "The sequence of the Orgyia pseudotsugata multinucleocapsid nuclear
RT   polyhedrosis virus genome.";
RL   Virology 229:381-399(1997).
CC   -!- FUNCTION: Envelope phosphoglycoprotein which mediates the fusion of
CC       viral and host endosomal membranes leading to virus entry into the host
CC       cell.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass
CC       membrane protein {ECO:0000305}. Host cell membrane {ECO:0000305};
CC       Single-pass membrane protein {ECO:0000305}.
CC   -!- PTM: Palmitoylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the baculoviridae gp64 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M22446; AAA46693.1; -; Genomic_DNA.
DR   EMBL; U75930; AAC59125.1; -; Genomic_DNA.
DR   PIR; A30232; VGNVPC.
DR   RefSeq; NP_046282.1; NC_001875.2.
DR   SMR; P13625; -.
DR   GeneID; 912029; -.
DR   KEGG; vg:912029; -.
DR   Proteomes; UP000009248; Genome.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019048; P:modulation by virus of host process; IEA:InterPro.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR004955; Baculovirus_Gp64.
DR   Pfam; PF03273; Baculo_gp64; 1.
PE   3: Inferred from homology;
KW   Fusion of virus membrane with host endosomal membrane;
KW   Fusion of virus membrane with host membrane; Glycoprotein;
KW   Host cell membrane; Host membrane; Lipoprotein; Membrane; Palmitate;
KW   Phosphoprotein; Signal; Transmembrane; Transmembrane helix;
KW   Viral envelope protein; Viral penetration into host cytoplasm; Virion;
KW   Virus entry into host cell.
FT   SIGNAL          1..17
FT   CHAIN           18..509
FT                   /note="Major envelope glycoprotein"
FT                   /id="PRO_0000036747"
FT   TRANSMEM        480..502
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   LIPID           479
FT                   /note="O-palmitoyl serine; by host"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        156
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        189
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        194
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        351
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        381
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        423
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        474
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   509 AA;  58179 MW;  441EBBEC61338957 CRC64;
     MVRIVVFILL CVRFSAPAEH CNAQMKSGPW RIKSLPIAAP KETLQKDVEI EIVETDLDQN
     VVIGYKGYYQ AYAYNGGSLD PNSRVEETMK TLDVAKEDLL MWGIRQQCEV GEELIDQWGS
     DSESCFRNMD GRGVWVAGKE LVKRQNNNHF AHHTCNRSWR CGVSTAKMYT RLECDDDTDD
     CKVTILDING TSINVTENKV LHRDGVSMIL KQKSTFSRRT EKVACLLIKD DKADPNSVTR
     EHCLVDNDIF DLSKNTWFCK FNRCIKRRSE NVVKQRPHTW RHDRPPKHDE GATATKGDLM
     HIQEELMYEN DLLRMNLELM HAHINKLNNM MHDLIVSVAK VDERLIGNLM NNSVSSTFLS
     DDTFLLMPCT SPPPHTSNCY NNSIYKEGRW VANTDTSQCI DFNNYKELAI DDDIEFWIPT
     IGNTSYHESW KDASGWSFIA QQKSNLISTM ENTKFGGHTT SLSDIADMAK GELNATLYSF
     MLGHGFTFVL IVGVILFLVC MLRNRPSHY