FUT10_BOVIN
ID FUT10_BOVIN Reviewed; 478 AA.
AC Q6A198; Q7YRE8;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Alpha-(1,3)-fucosyltransferase 10;
DE EC=2.4.1.- {ECO:0000250|UniProtKB:Q5F2L2, ECO:0000250|UniProtKB:Q6P4F1};
DE AltName: Full=Fucosyltransferase X;
DE Short=Fuc-TX;
DE Short=FucT-X;
DE AltName: Full=Galactoside 3-L-fucosyltransferase 10;
DE Short=Fucosyltransferase 10;
GN Name=FUT10;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Martinez-Duncker I., Oriol R., Mollicone R.;
RT "Phylogeny of fucosyltransferases.";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thymus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 17-478.
RA Germot A., Dupuy F., Loriol C., Julien R., Maftah A.;
RT "Genomic organization and expression profile of putative alpha 1,3-
RT fucosyltransferase genes, fut10 and fut11, in Bos taurus.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Predominantly fucosylates the innermost N-acetyl glucosamine
CC (GlcNAc) residue in biantennary N-glycan acceptors. Postulated to
CC generate core alpha(1->3)-fucose epitope within the chitobiose unit of
CC biantennary N-glycans, providing for a recognition signal to reorient
CC aberrantly folded glycoproteins for degradation (By similarity).
CC Involved in biosynthesis of Lewis X-carrying biantennary N-glycans that
CC regulate neuron stem cell self-renewal during brain development (By
CC similarity). {ECO:0000250|UniProtKB:Q5F2L2,
CC ECO:0000250|UniProtKB:Q6P4F1}.
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000250|UniProtKB:Q6P4F1}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q6P4F1}; Single-pass type II membrane protein
CC {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q6P4F1};
CC Single-pass type II membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 10 family.
CC {ECO:0000305}.
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DR EMBL; AJ786259; CAH05071.1; -; mRNA.
DR EMBL; BT020712; AAX08729.1; -; mRNA.
DR EMBL; BC147891; AAI47892.1; -; mRNA.
DR EMBL; AY344579; AAQ02331.1; -; mRNA.
DR RefSeq; NP_892032.1; NM_182987.1.
DR AlphaFoldDB; Q6A198; -.
DR SMR; Q6A198; -.
DR STRING; 9913.ENSBTAP00000007176; -.
DR CAZy; GT10; Glycosyltransferase Family 10.
DR PaxDb; Q6A198; -.
DR PRIDE; Q6A198; -.
DR GeneID; 360195; -.
DR KEGG; bta:360195; -.
DR CTD; 84750; -.
DR eggNOG; KOG2619; Eukaryota.
DR InParanoid; Q6A198; -.
DR OrthoDB; 551308at2759; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046920; F:alpha-(1->3)-fucosyltransferase activity; IBA:GO_Central.
DR GO; GO:0008417; F:fucosyltransferase activity; ISS:UniProtKB.
DR GO; GO:0036065; P:fucosylation; IBA:GO_Central.
DR GO; GO:0036071; P:N-glycan fucosylation; ISS:UniProtKB.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.11660; -; 1.
DR InterPro; IPR017176; Alpha-1_3-FUT_met.
DR InterPro; IPR031481; Glyco_tran_10_N.
DR InterPro; IPR001503; Glyco_trans_10.
DR InterPro; IPR038577; GT10-like_C_sf.
DR PANTHER; PTHR11929; PTHR11929; 1.
DR Pfam; PF17039; Glyco_tran_10_N; 1.
DR Pfam; PF00852; Glyco_transf_10; 1.
DR PIRSF; PIRSF037332; Alpha1_3FUT_met; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Glycoprotein; Glycosyltransferase; Golgi apparatus;
KW Membrane; Reference proteome; Signal-anchor; Transferase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..478
FT /note="Alpha-(1,3)-fucosyltransferase 10"
FT /id="PRO_0000299000"
FT TOPO_DOM 1..9
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 10..30
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 31..478
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT CARBOHYD 110
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 168
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 478 AA; 55717 MW; 73A98FB7FFECBBB7 CRC64;
MVRIQRGKLL AFCLCVMATV FLLITLQVVV ELGKFEGKKF KNSHLKDGHA QMEAEPLHLH
PFFNREGLTL NRKKTLAADS FPIMLWWSPL TGETGRLGQC GADACFFTIN RTYLHHHRTK
AFLFYGTDFS IDSLPLPRKA HHDWALFHEE SPKNNYKLFH QPVITLFNYT ATFSRHSHLP
LTTQYLEGTE VLTSLRHLVP LRSKNHLRKS LAPLVYVQSD CDPPSDRDSY VRELMTYIEV
DSYGECLRNK PLPPQLSNPA SMDADGFFRI LAQYKFILAF ENAVCDDYIT EKLWRPLKLG
VVPVYYGSPS IADWLPSNRS AILVSEFSHP RELASYIRAL DRDDRRYQAY IEWKLKGEIS
NQRLLTALRE RKWGVQDVKQ DNYIDAFECM VCTKVWDNIR LQEKGLPPKR WQADVTHLSC
PEPTVFAFSP LVPRRRSLRE MWIPSFQQSK KEARALRWLV DRNQNFSTQE FWALVFKD
