FUT10_DANRE
ID FUT10_DANRE Reviewed; 458 AA.
AC Q5F2N3; B3DIM2;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 3.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Alpha-(1,3)-fucosyltransferase 10;
DE EC=2.4.1.-;
DE AltName: Full=Fucosyltransferase X;
DE Short=Fuc-TX;
DE Short=FucT-X;
DE AltName: Full=Galactoside 3-L-fucosyltransferase 10;
DE Short=Fucosyltransferase 10;
GN Name=fut10; ORFNames=zgc:195147;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Martinez-Duncker I., Oriol R., Mollicone R.;
RT "Phylogeny of fucosyltransferases.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable fucosyltransferase. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane
CC {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5F2N3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5F2N3-2; Sequence=VSP_036603, VSP_036604;
CC -!- SIMILARITY: Belongs to the glycosyltransferase 10 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI63176.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAI52076.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AJ879586; CAI52076.1; ALT_INIT; mRNA.
DR EMBL; BC163176; AAI63176.1; ALT_INIT; mRNA.
DR RefSeq; NP_001012374.1; NM_001012374.1.
DR AlphaFoldDB; Q5F2N3; -.
DR STRING; 7955.ENSDARP00000042310; -.
DR CAZy; GT10; Glycosyltransferase Family 10.
DR PaxDb; Q5F2N3; -.
DR Ensembl; ENSDART00000161506; ENSDARP00000135630; ENSDARG00000100322. [Q5F2N3-1]
DR GeneID; 497615; -.
DR KEGG; dre:497615; -.
DR CTD; 84750; -.
DR ZFIN; ZDB-GENE-081022-183; fut10.
DR eggNOG; KOG2619; Eukaryota.
DR GeneTree; ENSGT00940000160287; -.
DR InParanoid; Q5F2N3; -.
DR PhylomeDB; Q5F2N3; -.
DR Reactome; R-DRE-9037629; Lewis blood group biosynthesis.
DR UniPathway; UPA00378; -.
DR PRO; PR:Q5F2N3; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 10.
DR Bgee; ENSDARG00000100322; Expressed in gastrula and 18 other tissues.
DR ExpressionAtlas; Q5F2N3; baseline.
DR GO; GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:InterPro.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046920; F:alpha-(1->3)-fucosyltransferase activity; IBA:GO_Central.
DR GO; GO:0036065; P:fucosylation; IBA:GO_Central.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.11660; -; 1.
DR InterPro; IPR017176; Alpha-1_3-FUT_met.
DR InterPro; IPR031481; Glyco_tran_10_N.
DR InterPro; IPR001503; Glyco_trans_10.
DR InterPro; IPR038577; GT10-like_C_sf.
DR PANTHER; PTHR11929; PTHR11929; 1.
DR Pfam; PF17039; Glyco_tran_10_N; 1.
DR Pfam; PF00852; Glyco_transf_10; 1.
DR PIRSF; PIRSF037332; Alpha1_3FUT_met; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Glycosyltransferase; Golgi apparatus;
KW Membrane; Reference proteome; Signal-anchor; Transferase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..458
FT /note="Alpha-(1,3)-fucosyltransferase 10"
FT /id="PRO_0000299006"
FT TOPO_DOM 1..11
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 12..32
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 33..458
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT CARBOHYD 92
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 150
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 300
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 445
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 28..30
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_036603"
FT VAR_SEQ 387
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_036604"
FT CONFLICT 11
FT /note="S -> T (in Ref. 2; AAI63176)"
FT /evidence="ECO:0000305"
FT CONFLICT 54
FT /note="A -> V (in Ref. 2; AAI63176)"
FT /evidence="ECO:0000305"
FT CONFLICT 99
FT /note="P -> A (in Ref. 2; AAI63176)"
FT /evidence="ECO:0000305"
FT CONFLICT 102
FT /note="K -> E (in Ref. 2; AAI63176)"
FT /evidence="ECO:0000305"
FT CONFLICT 389
FT /note="P -> S (in Ref. 2; AAI63176)"
FT /evidence="ECO:0000305"
FT CONFLICT 453
FT /note="R -> K (in Ref. 2; AAI63176)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 458 AA; 54036 MW; 1C5510E6DA32C926 CRC64;
MRRISVKKLC SFCLCACAFA FLVMTFQVIE LLGQFEQTEH RQQIKRFEDI KVQANAHVSD
VQYPVIVWWS PLTGELGRLG ECGHNRCFFT VNKSYYSHPQ TKAFLFYGTD FSIESLPLPR
HKQHQWALFH EESPKNNYKL FHKPLITQFN HTATFSRHSH LPLTTQHLED INTLTAQTHL
LPLSYKNHLR QTLAPVVYVQ SDCDPPSDRD TYIRELMQHI QVDSYGQCLH NKDLPPHLRD
STAMDDQDFY KILAQYKFIL AFENAVCDDY ITEKLWRPLK LGVVPVYYGA PNIHMWLPDN
QSAIVVNPNE PPKKLAQYLK RLDKNDWEYL KYLEWKHKRE ITNINLLKEL KERPWGVQDI
TQDNFIDVFE CMVCSRVWEN IHRQEEKLPP KVWRAEESHL TCPPPKLFDF ALSSSSSLRQ
MWGASYEQSK REARALAQML HTNTNFTITQ FWREVFTD
