ID   FUT10_XENTR             Reviewed;         471 AA.
AC   Q6A1G3;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Alpha-(1,3)-fucosyltransferase 10;
DE            EC=2.4.1.-;
DE   AltName: Full=Fucosyltransferase X;
DE            Short=Fuc-TX;
DE            Short=FucT-X;
DE   AltName: Full=Galactoside 3-L-fucosyltransferase 10;
DE            Short=Fucosyltransferase 10;
GN   Name=fut10;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Martinez-Duncker I., Oriol R., Mollicone R.;
RT   "Phylogeny of fucosyltransferases.";
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable fucosyltransferase. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane
CC       {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 10 family.
CC       {ECO:0000305}.
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DR   EMBL; AJ784815; CAH04944.1; -; mRNA.
DR   RefSeq; NP_001002903.1; NM_001002903.1.
DR   AlphaFoldDB; Q6A1G3; -.
DR   STRING; 8364.ENSXETP00000037211; -.
DR   CAZy; GT10; Glycosyltransferase Family 10.
DR   PaxDb; Q6A1G3; -.
DR   GeneID; 444886; -.
DR   KEGG; xtr:444886; -.
DR   CTD; 84750; -.
DR   Xenbase; XB-GENE-976919; fut10.
DR   eggNOG; KOG2619; Eukaryota.
DR   InParanoid; Q6A1G3; -.
DR   OrthoDB; 551308at2759; -.
DR   Reactome; R-XTR-9037629; Lewis blood group biosynthesis.
DR   UniPathway; UPA00378; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046920; F:alpha-(1->3)-fucosyltransferase activity; IBA:GO_Central.
DR   GO; GO:0036065; P:fucosylation; IBA:GO_Central.
DR   GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.11660; -; 1.
DR   InterPro; IPR017176; Alpha-1_3-FUT_met.
DR   InterPro; IPR031481; Glyco_tran_10_N.
DR   InterPro; IPR001503; Glyco_trans_10.
DR   InterPro; IPR038577; GT10-like_C_sf.
DR   PANTHER; PTHR11929; PTHR11929; 1.
DR   Pfam; PF17039; Glyco_tran_10_N; 1.
DR   Pfam; PF00852; Glyco_transf_10; 1.
DR   PIRSF; PIRSF037332; Alpha1_3FUT_met; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Glycosyltransferase; Golgi apparatus; Membrane;
KW   Reference proteome; Signal-anchor; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..471
FT                   /note="Alpha-(1,3)-fucosyltransferase 10"
FT                   /id="PRO_0000299008"
FT   TOPO_DOM        1..8
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        9..29
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        30..471
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        102
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        122
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        160
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        310
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        457
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   471 AA;  55618 MW;  6C8B69452D6DC8BB CRC64;
     MNRMWEKKFW ISCFFIILFF ILVTLQVMVE LGRFEKRETK SFTVIDIKEQ KKPLLKHIKE
     KSNSRLRHLK DNYPIMLWWS PLTGENGRLG QCGTDTCFFT INRTYLQDPM TKAILFYGTD
     FNMTSLPLPR EISHEWALFH EESPKNNYKL FHEPAITLFN HTATFSRHSH LPLTSQYLEG
     LQALRSKEYL ISIQKKNFLR KRLAPLAYVQ SDCDPPSDRD SYVQELMKYI AVDSYGECLH
     NRDLPQQVNN PSSMDDSQFH HILAQYKFIL AFENAVCEDY ITEKLWRPLK LGAVPVYFGA
     PNVENWLPSN KSAIIVGRFS HPKELATYIK KLDKNDKLYM QFIEWKLHGN INNKHLLSTI
     TERKWGVQDV TQDNYIDAFE CMICKRVWEN VRLKDRVSTT KLWNAESLHL NCPAPEAFSF
     LPGHLLKSSM REMWKPSFEQ SKKEAKALRT LVDRNRNFTT VEFWNLVFKF Q