ID   FUT11_DANRE             Reviewed;         483 AA.
AC   Q08C60;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Alpha-(1,3)-fucosyltransferase 11;
DE            EC=2.4.1.-;
DE   AltName: Full=Fucosyltransferase XI;
DE            Short=Fuc-TXI;
DE            Short=FucT-XI;
DE   AltName: Full=Galactoside 3-L-fucosyltransferase 11;
DE            Short=Fucosyltransferase 11;
GN   Name=fut11; ORFNames=zgc:153537;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable fucosyltransferase. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane
CC       {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 10 family.
CC       {ECO:0000305}.
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DR   EMBL; BC124380; AAI24381.1; -; mRNA.
DR   RefSeq; NP_001070642.1; NM_001077174.1.
DR   AlphaFoldDB; Q08C60; -.
DR   STRING; 7955.ENSDARP00000074921; -.
DR   CAZy; GT10; Glycosyltransferase Family 10.
DR   PaxDb; Q08C60; -.
DR   Ensembl; ENSDART00000165099; ENSDARP00000134474; ENSDARG00000102402.
DR   GeneID; 568888; -.
DR   KEGG; dre:568888; -.
DR   CTD; 170384; -.
DR   ZFIN; ZDB-GENE-060929-728; fut11.
DR   eggNOG; KOG2619; Eukaryota.
DR   GeneTree; ENSGT00940000158983; -.
DR   HOGENOM; CLU_032075_0_1_1; -.
DR   InParanoid; Q08C60; -.
DR   OMA; ERIDCPR; -.
DR   OrthoDB; 551308at2759; -.
DR   PhylomeDB; Q08C60; -.
DR   TreeFam; TF316348; -.
DR   Reactome; R-DRE-9037629; Lewis blood group biosynthesis.
DR   UniPathway; UPA00378; -.
DR   PRO; PR:Q08C60; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 14.
DR   Bgee; ENSDARG00000102402; Expressed in early embryo and 21 other tissues.
DR   GO; GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046920; F:alpha-(1->3)-fucosyltransferase activity; IBA:GO_Central.
DR   GO; GO:0036065; P:fucosylation; IBA:GO_Central.
DR   GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.11660; -; 1.
DR   InterPro; IPR017176; Alpha-1_3-FUT_met.
DR   InterPro; IPR031481; Glyco_tran_10_N.
DR   InterPro; IPR001503; Glyco_trans_10.
DR   InterPro; IPR038577; GT10-like_C_sf.
DR   PANTHER; PTHR11929; PTHR11929; 1.
DR   Pfam; PF17039; Glyco_tran_10_N; 1.
DR   Pfam; PF00852; Glyco_transf_10; 1.
DR   PIRSF; PIRSF037332; Alpha1_3FUT_met; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Glycosyltransferase; Golgi apparatus;
KW   Membrane; Reference proteome; Signal-anchor; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..483
FT                   /note="Alpha-(1,3)-fucosyltransferase 11"
FT                   /id="PRO_0000299013"
FT   TOPO_DOM        1
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        2..21
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        22..483
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   REGION          387..425
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        151
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        303
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        406
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        428
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        456
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        480
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        83..88
FT                   /evidence="ECO:0000250"
FT   DISULFID        374..377
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   483 AA;  55712 MW;  2AC0B98E3A6B741E CRC64;
     MALCLWLFLV LPICCWCQGA VDLGDSGVFQ PQSALTDMEF ASVSTYRGPG NTDPRPNKEL
     PILLWWSSNL FPHFPGDTER VDCAHSSCLV TSNRKVQLYR RTASIIFYGT DFRAYEAPLP
     RLPHQTWALF HEESPMNNYL LSHSVGIRLF NYTATFRRES DYPLTLQWLP SLDYLLAPTA
     ISLQEKNHWR QAGLAPVLYM QSHCDVPSDR DRFVQELMKY IEIDSYGKCL NNKPLPEYLE
     DTSTATSEDR RFMSFVARYK FHLALENGLC PDYMTEKLWR PMHQGCVPIY RGSTTVADWL
     PNNHSAILVE DFSTPRELAD FIKALDQDDV EYLRYLKYKT PSEITNLRLL EGLESREWGV
     NDMSKPNYLN GFECFVCDKE NERLAARKAH RKNPKQNQPP QPKMANSSHM GCPLPSPGYG
     PVENVEPNDS WLQMWPQDYW QSLDQAEGLE SLIRHNVSEP SLLWQHIQSI AVRRARGLSN
     DSR