FUT6_ARATH
ID FUT6_ARATH Reviewed; 537 AA.
AC Q9XI80; F4HUF1; Q8GUI5; Q9LMF2;
DT 05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Fucosyltransferase 6;
DE Short=AtFUT6;
DE EC=2.4.1.-;
GN Name=FUT6; OrderedLocusNames=At1g14080; ORFNames=F16A14.28, F7A19.16;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-537.
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP IDENTIFICATION AS A PUTATIVE FUCOSYLTRANSFERASE, AND TISSUE SPECIFICITY.
RX PubMed=11743104; DOI=10.1104/pp.010596;
RA Sarria R., Wagner T.A., O'Neill M.A., Faik A., Wilkerson C.G., Keegstra K.,
RA Raikhel N.V.;
RT "Characterization of a family of Arabidopsis genes related to xyloglucan
RT fucosyltransferase1.";
RL Plant Physiol. 127:1595-1606(2001).
CC -!- FUNCTION: May be involved in cell wall biosynthesis. May act as a
CC fucosyltransferase.
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane
CC {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
CC Note=Membrane-bound form in trans cisternae of Golgi. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in roots and flowers.
CC {ECO:0000269|PubMed:11743104}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 37 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF79408.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAO00849.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAP68320.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC007576; AAD39293.1; -; Genomic_DNA.
DR EMBL; AC068197; AAF79408.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE29105.2; -; Genomic_DNA.
DR EMBL; BT002489; AAO00849.1; ALT_INIT; mRNA.
DR EMBL; BT008881; AAP68320.1; ALT_INIT; mRNA.
DR PIR; B86274; B86274.
DR RefSeq; NP_172860.2; NM_101273.3.
DR AlphaFoldDB; Q9XI80; -.
DR SMR; Q9XI80; -.
DR STRING; 3702.AT1G14080.1; -.
DR CAZy; GT37; Glycosyltransferase Family 37.
DR PaxDb; Q9XI80; -.
DR PRIDE; Q9XI80; -.
DR ProteomicsDB; 230537; -.
DR EnsemblPlants; AT1G14080.1; AT1G14080.1; AT1G14080.
DR GeneID; 837968; -.
DR Gramene; AT1G14080.1; AT1G14080.1; AT1G14080.
DR KEGG; ath:AT1G14080; -.
DR Araport; AT1G14080; -.
DR eggNOG; ENOG502SC60; Eukaryota.
DR InParanoid; Q9XI80; -.
DR OMA; DNAGYFQ; -.
DR OrthoDB; 364119at2759; -.
DR PhylomeDB; Q9XI80; -.
DR BioCyc; ARA:AT1G14080-MON; -.
DR UniPathway; UPA00378; -.
DR PRO; PR:Q9XI80; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9XI80; baseline and differential.
DR GO; GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008417; F:fucosyltransferase activity; IBA:GO_Central.
DR GO; GO:0008107; F:galactoside 2-alpha-L-fucosyltransferase activity; IEA:InterPro.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR GO; GO:0009969; P:xyloglucan biosynthetic process; IBA:GO_Central.
DR InterPro; IPR004938; XG_FTase.
DR PANTHER; PTHR31889; PTHR31889; 1.
DR Pfam; PF03254; XG_FTase; 1.
PE 2: Evidence at transcript level;
KW Cell wall biogenesis/degradation; Glycoprotein; Glycosyltransferase;
KW Golgi apparatus; Membrane; Reference proteome; Signal-anchor; Transferase;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..537
FT /note="Fucosyltransferase 6"
FT /id="PRO_0000193915"
FT TOPO_DOM 1..20
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 21..41
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 42..537
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT CARBOHYD 54
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 231
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 378
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 537 AA; 61191 MW; 25DA4756D4394EA2 CRC64;
MYHIFQISSE VFRAFGLKMK ILLTLVFSGL LIWSVVLVSF SNDFNNQLLV ATSNVSRESE
TPRDRLIGGL LTADFDEGSC LSRYQQSLLY RKASPYKPSE YLVSKLRSYE KLHKRCGPGT
DAYKKATEIL GHDDENYASK SVGECRYIVW VAVYGLGNRI LTLASVFLYA LLTERVVLVD
QSKDISDLFC EPFPGTSWLL PLEFPLMKQI DGYNKGYSRC YGTMLNNQAI NSTLIPPHLY
LHILHDSRDN DKMFFCQKDQ SLVDKVPWLI VKANVYFVPS LWLNPTFQTE LMKLFPQKEA
VFHHLARYLF HPTNQVWGLI TRSYNAYLSR ADETLGIQIR VFSDRAGYFQ HVMDQVVACT
RRENLLPEPA AQEEPKVNIS RSQKLKAVLV TSLYPEYSET LKNMYWERPS STGEIIEVYQ
PSGERVQQTD KKLHDQKALA EMYLLSLTDK IVTSARSTFG YVAHSLGGLK PWLLYQPTGP
TAPDPPCIQS TSMDPCHLTP PSHGCEPEWG TNSGKVVPFV RHCEDRGNDG LKLFDEL
