FUTSC_DROME
ID FUTSC_DROME Reviewed; 5495 AA.
AC Q9W596; A8JTS2; B2YGG3; O76891;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 4.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Microtubule-associated protein futsch;
DE AltName: Full=MAP1B homolog;
DE Contains:
DE RecName: Full=Futsch heavy chain;
DE Contains:
DE RecName: Full=Futsch light chain LC(f);
GN Name=futsch; ORFNames=CG34387;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=Oregon-R {ECO:0000269|PubMed:10839355};
RX PubMed=10839355; DOI=10.1016/s0896-6273(00)81169-1;
RA Hummel T., Krukkert K., Roos J., Davis G., Klambt C.;
RT "Drosophila Futsch/22C10 is a MAP1B-like protein required for dendritic and
RT axonal development.";
RL Neuron 26:357-370(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3] {ECO:0000305}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000312|EMBL:CAA20006.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Oregon-R {ECO:0000269|PubMed:10731137};
RX PubMed=10731137; DOI=10.1126/science.287.5461.2220;
RA Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D., Barrell B.G.,
RA Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Borkova D., Minana B., Kafatos F.C.,
RA Louis C., Siden-Kiamos I., Bolshakov S., Papagiannakis G., Spanos L.,
RA Cox S., Madueno E., de Pablos B., Modolell J., Peter A., Schoettler P.,
RA Werner M., Mourkioti F., Beinert N., Dowe G., Schaefer U., Jaeckle H.,
RA Bucheton A., Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S.,
RA McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C.,
RA Glover D.M.;
RT "From sequence to chromosome: the tip of the X chromosome of D.
RT melanogaster.";
RL Science 287:2220-2222(2000).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 5329-5495, SUBUNIT, AND PROTEOLYTIC CLEAVAGE.
RC STRAIN=Canton-S;
RX PubMed=18419581; DOI=10.1042/bj20071449;
RA Zou B., Yan H., Kawasaki F., Ordway R.W.;
RT "MAP1 structural organization in Drosophila: in vivo analysis of FUTSCH
RT reveals heavy- and light-chain subunits generated by proteolytic processing
RT at a conserved cleavage site.";
RL Biochem. J. 414:63-71(2008).
RN [6] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=10839356; DOI=10.1016/s0896-6273(00)81170-8;
RA Roos J., Hummel T., Ng N., Klambt C., Davis G.W.;
RT "Drosophila Futsch regulates synaptic microtubule organization and is
RT necessary for synaptic growth.";
RL Neuron 26:371-382(2000).
RN [7] {ECO:0000305}
RP FUNCTION, AND INTERACTION WITH FMR1.
RX PubMed=11733059; DOI=10.1016/s0092-8674(01)00589-x;
RA Zhang Y.Q., Bailey A.M., Matthies H.J.G., Renden R.B., Smith M.A.,
RA Speese S.D., Rubin G.M., Broadie K.S.;
RT "Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to
RT control synaptic structure and function.";
RL Cell 107:591-603(2001).
RN [8]
RP PHOSPHORYLATION AT SER-2800 AND SER-4950.
RX PubMed=16949836; DOI=10.1016/j.mcn.2006.07.004;
RA Gogel S., Wakefield S., Tear G., Klambt C., Gordon-Weeks P.R.;
RT "The Drosophila microtubule associated protein Futsch is phosphorylated by
RT Shaggy/Zeste-white 3 at an homologous GSK3beta phosphorylation site in
RT MAP1B.";
RL Mol. Cell. Neurosci. 33:188-199(2006).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3067; SER-3071 AND SER-3075,
RP AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=17372656; DOI=10.1039/b617545g;
RA Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A.,
RA Eng J.K., Aebersold R., Tao W.A.;
RT "An integrated chemical, mass spectrometric and computational strategy for
RT (quantitative) phosphoproteomics: application to Drosophila melanogaster
RT Kc167 cells.";
RL Mol. Biosyst. 3:275-286(2007).
RN [10]
RP PHOSPHORYLATION BY LRRK2.
RX PubMed=21159966; DOI=10.1523/jneurosci.1807-10.2010;
RA Lee S., Liu H.P., Lin W.Y., Guo H., Lu B.;
RT "LRRK2 kinase regulates synaptic morphology through distinct substrates at
RT the presynaptic and postsynaptic compartments of the Drosophila
RT neuromuscular junction.";
RL J. Neurosci. 30:16959-16969(2010).
RN [11]
RP FUNCTION, SUBUNIT, AND DISRUPTION PHENOTYPE.
RX PubMed=31156389; DOI=10.3389/fncel.2019.00192;
RA Shi Q., Lin Y.Q., Saliba A., Xie J., Neely G.G., Banerjee S.;
RT "Tubulin polymerization promoting protein, ringmaker, and MAP1B homolog
RT futsch coordinate microtubule organization and synaptic growth.";
RL Front. Cell. Neurosci. 13:192-192(2019).
CC -!- FUNCTION: During embryogenesis, necessary for dendritic and axonal
CC organization and growth at the neuromuscular junction through the
CC regulation of the synaptic microtubule cytoskeleton (PubMed:10839355,
CC PubMed:10839356, PubMed:11733059). Microtubule hairpin loops are found
CC within a small subset of synaptic boutons at the neuromuscular synapse,
CC these loops are stabilized by Futsch (PubMed:10839355, PubMed:10839356,
CC PubMed:11733059). Loop morphology and dynamics suggest that
CC rearrangement of these microtubule-based loops is a critical component
CC of the process of bouton division and for subsequent nerve-terminal
CC growth and branching (PubMed:10839355, PubMed:10839356,
CC PubMed:11733059). Translation is repressed by Fmr1 (PubMed:10839355,
CC PubMed:10839356, PubMed:11733059). Together with Ringer, required for
CC neuromuscular junction (NMJ) bouton growth by regulating synaptic
CC microtubules (PubMed:31156389). {ECO:0000269|PubMed:10839355,
CC ECO:0000269|PubMed:10839356, ECO:0000269|PubMed:11733059,
CC ECO:0000269|PubMed:31156389}.
CC -!- SUBUNIT: Heterodimer of a heavy and a light chain (PubMed:18419581).
CC Interacts with Fmr1 (PubMed:11733059). Found in a complex with tubulin
CC and Futsch (PubMed:31156389). {ECO:0000269|PubMed:11733059,
CC ECO:0000269|PubMed:18419581, ECO:0000269|PubMed:31156389}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10839355}.
CC Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10839355,
CC ECO:0000269|PubMed:10839356}. Note=Microtubule-associated.
CC {ECO:0000269|PubMed:10839355}.
CC -!- TISSUE SPECIFICITY: Neuronal cells within the PNS and CNS.
CC {ECO:0000269|PubMed:10839355, ECO:0000269|PubMed:10839356}.
CC -!- DEVELOPMENTAL STAGE: All stages. {ECO:0000269|PubMed:10839355}.
CC -!- PTM: Several minor light chains can be created with markedly different
CC pIs. {ECO:0000269|PubMed:18419581}.
CC -!- PTM: Phosphorylated by SGG/GSK3. Phosphorylated by LRRK2 at the
CC presynapse of neuromuscular junctions, which negatively regulates the
CC activity controlling synaptic differentiation.
CC {ECO:0000269|PubMed:16949836, ECO:0000269|PubMed:17372656,
CC ECO:0000269|PubMed:21159966}.
CC -!- DISRUPTION PHENOTYPE: Flies lacking both Ringer and Futsch display a
CC significant reduction in microtubule loops at the neuromuscular
CC junctions (NMJ) and reduced acetylated-tubulin levels.
CC {ECO:0000269|PubMed:31156389}.
CC -!- MISCELLANEOUS: 'Futsch' means 'gone' in German.
CC {ECO:0000303|PubMed:10839355}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA20006.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AE014298; ABW09325.1; -; Genomic_DNA.
DR EMBL; AL031128; CAA20006.1; ALT_SEQ; Genomic_DNA.
DR EMBL; EU523737; ACD38216.1; -; mRNA.
DR PIR; T13564; T13564.
DR RefSeq; NP_001096864.1; NM_001103394.3.
DR RefSeq; NP_001162632.2; NM_001169161.3.
DR RefSeq; NP_001245461.1; NM_001258532.1.
DR BioGRID; 625175; 24.
DR IntAct; Q9W596; 10.
DR STRING; 7227.FBpp0300236; -.
DR iPTMnet; Q9W596; -.
DR PaxDb; Q9W596; -.
DR PRIDE; Q9W596; -.
DR EnsemblMetazoa; FBtr0112628; FBpp0111540; FBgn0259108.
DR EnsemblMetazoa; FBtr0307597; FBpp0300235; FBgn0259108.
DR EnsemblMetazoa; FBtr0307598; FBpp0300236; FBgn0259108.
DR GeneID; 5740544; -.
DR KEGG; dme:Dmel_CG34387; -.
DR UCSC; CG34387-RC; d. melanogaster.
DR CTD; 5740544; -.
DR FlyBase; FBgn0259108; futsch.
DR VEuPathDB; VectorBase:FBgn0259108; -.
DR eggNOG; KOG3592; Eukaryota.
DR HOGENOM; CLU_223193_0_0_1; -.
DR InParanoid; Q9W596; -.
DR OMA; WGTTEES; -.
DR OrthoDB; 22057at2759; -.
DR PhylomeDB; Q9W596; -.
DR SignaLink; Q9W596; -.
DR BioGRID-ORCS; 5740544; 0 hits in 1 CRISPR screen.
DR ChiTaRS; futsch; fly.
DR GenomeRNAi; 5740544; -.
DR PRO; PR:Q9W596; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0259108; Expressed in second segment of antenna (Drosophila) and 7 other tissues.
DR ExpressionAtlas; Q9W596; baseline and differential.
DR Genevisible; Q9W596; DM.
DR GO; GO:0030424; C:axon; IDA:FlyBase.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0030425; C:dendrite; IDA:FlyBase.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005875; C:microtubule associated complex; IDA:UniProtKB.
DR GO; GO:0015630; C:microtubule cytoskeleton; IDA:FlyBase.
DR GO; GO:0031594; C:neuromuscular junction; IMP:UniProtKB.
DR GO; GO:0043025; C:neuronal cell body; IDA:FlyBase.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0003779; F:actin binding; IBA:GO_Central.
DR GO; GO:0019900; F:kinase binding; IPI:BHF-UCL.
DR GO; GO:0008017; F:microtubule binding; IDA:UniProtKB.
DR GO; GO:0008088; P:axo-dendritic transport; IMP:FlyBase.
DR GO; GO:0007409; P:axonogenesis; IMP:FlyBase.
DR GO; GO:0016358; P:dendrite development; IBA:GO_Central.
DR GO; GO:0048813; P:dendrite morphogenesis; IMP:FlyBase.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IMP:UniProtKB.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IMP:FlyBase.
DR GO; GO:1901215; P:negative regulation of neuron death; IMP:FlyBase.
DR GO; GO:0060052; P:neurofilament cytoskeleton organization; IMP:FlyBase.
DR GO; GO:0008355; P:olfactory learning; IMP:FlyBase.
DR GO; GO:0031114; P:regulation of microtubule depolymerization; IBA:GO_Central.
DR GO; GO:0008582; P:regulation of synaptic assembly at neuromuscular junction; IMP:UniProtKB.
DR InterPro; IPR026074; MAP1.
DR InterPro; IPR009603; MAP_Futsch.
DR PANTHER; PTHR13843; PTHR13843; 9.
DR Pfam; PF06740; DUF1213; 51.
PE 1: Evidence at protein level;
KW Cytoplasm; Cytoskeleton; Developmental protein; Microtubule;
KW Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..5495
FT /note="Microtubule-associated protein futsch"
FT /id="PRO_0000087388"
FT CHAIN 1..5328
FT /note="Futsch heavy chain"
FT /id="PRO_0000418374"
FT CHAIN 5329..5495
FT /note="Futsch light chain LC(f)"
FT /id="PRO_0000418375"
FT REPEAT 1469..1502
FT /note="1"
FT REPEAT 1513..1539
FT /note="2"
FT REPEAT 1622..1649
FT /note="3"
FT REPEAT 1660..1686
FT /note="4"
FT REPEAT 1690..1718
FT /note="5"
FT REPEAT 1755..1782
FT /note="6"
FT REPEAT 1790..1818
FT /note="7"
FT REPEAT 1837..1865
FT /note="8"
FT REPEAT 1874..1902
FT /note="9"
FT REPEAT 1911..1939
FT /note="10"
FT REPEAT 1948..1976
FT /note="11"
FT REPEAT 1985..2013
FT /note="12"
FT REPEAT 2022..2050
FT /note="13"
FT REPEAT 2059..2087
FT /note="14"
FT REPEAT 2096..2124
FT /note="15"
FT REPEAT 2133..2161
FT /note="16"
FT REPEAT 2170..2198
FT /note="17"
FT REPEAT 2215..2243
FT /note="18"
FT REPEAT 2262..2292
FT /note="19"
FT REPEAT 2355..2391
FT /note="20"
FT REPEAT 2703..2726
FT /note="21"
FT REPEAT 2761..2787
FT /note="22"
FT REPEAT 2820..2846
FT /note="23"
FT REPEAT 2864..2892
FT /note="24"
FT REPEAT 2907..2933
FT /note="25"
FT REPEAT 2956..2987
FT /note="26"
FT REPEAT 3006..3034
FT /note="27"
FT REPEAT 3049..3075
FT /note="28"
FT REPEAT 3089..3117
FT /note="29"
FT REPEAT 3131..3158
FT /note="30"
FT REPEAT 3200..3224
FT /note="31"
FT REPEAT 3228..3256
FT /note="32"
FT REPEAT 3265..3293
FT /note="33"
FT REPEAT 3302..3330
FT /note="34"
FT REPEAT 3339..3367
FT /note="35"
FT REPEAT 3376..3404
FT /note="36"
FT REPEAT 3413..3441
FT /note="37"
FT REPEAT 3450..3478
FT /note="38"
FT REPEAT 3487..3515
FT /note="39"
FT REPEAT 3524..3552
FT /note="40"
FT REPEAT 3561..3589
FT /note="41"
FT REPEAT 3598..3626
FT /note="42"
FT REPEAT 3635..3663
FT /note="43"
FT REPEAT 3672..3700
FT /note="44"
FT REPEAT 3709..3737
FT /note="45"
FT REPEAT 3746..3774
FT /note="46"
FT REPEAT 3783..3811
FT /note="47"
FT REPEAT 3820..3848
FT /note="48"
FT REPEAT 3867..3894
FT /note="49"
FT REPEAT 3895..3921
FT /note="50"
FT REPEAT 3931..3958
FT /note="51"
FT REPEAT 3968..3995
FT /note="52"
FT REPEAT 4005..4032
FT /note="53"
FT REGION 1..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 656..975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 988..1074
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1086..1111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1128..1167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1185..1204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1255..1275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1306..1358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1402..1840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1469..4032
FT /note="53 X approximate repeat"
FT REGION 1866..2631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2709..2810
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2830..4166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4196..4230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4362..4612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4636..4668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4687..4975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5035..5065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5101..5138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5170..5199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5328..5350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..699
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 700..718
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 755..797
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 816..834
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 842..891
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 957..975
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 988..1011
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1012..1028
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1043..1074
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1128..1162
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1405..1442
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1523..1559
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1567..1667
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1675..1784
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1805..1819
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1820..1836
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1886..1948
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1964..1980
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1994..2029
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2037..2062
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2074..2099
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2111..2136
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2148..2173
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2185..2210
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2222..2247
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2259..2284
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2296..2321
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2333..2358
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2370..2394
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2414..2433
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2462..2498
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2511..2547
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2564..2592
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2608..2622
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2778..2796
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2841..2860
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2894..2915
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2916..2934
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2954..2974
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2976..3052
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3083..3140
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3155..3214
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3221..3243
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3263..3296
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3350..3364
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3377..3399
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3415..3435
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3447..3468
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3480..3505
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3517..3542
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3554..3579
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3595..3616
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3628..3653
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3665..3690
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3706..3727
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3739..3764
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3776..3801
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3813..3838
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3850..3875
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3887..3912
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3924..3948
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3962..3986
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3998..4023
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4035..4061
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4064..4080
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4081..4097
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4112..4138
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4362..4409
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4416..4430
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4432..4461
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4462..4481
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4482..4509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4538..4574
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4591..4612
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4650..4666
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4699..4719
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4783..4801
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4802..4855
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4897..4945
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5035..5061
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5178..5199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2800
FT /note="Phosphoserine; by GSK3-beta"
FT /evidence="ECO:0000305|PubMed:16949836"
FT MOD_RES 3067
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:17372656"
FT MOD_RES 3071
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:17372656"
FT MOD_RES 3075
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:17372656"
FT MOD_RES 4950
FT /note="Phosphoserine; by GSK3-beta"
FT /evidence="ECO:0000305|PubMed:16949836"
FT CONFLICT 647..648
FT /note="Missing (in Ref. 4; CAA20006)"
FT /evidence="ECO:0000305"
FT CONFLICT 732
FT /note="A -> T (in Ref. 4; CAA20006)"
FT /evidence="ECO:0000305"
FT CONFLICT 799
FT /note="T -> A (in Ref. 4; CAA20006)"
FT /evidence="ECO:0000305"
FT CONFLICT 1322
FT /note="G -> N (in Ref. 4; CAA20006)"
FT /evidence="ECO:0000305"
FT CONFLICT 2312
FT /note="T -> S (in Ref. 4; CAA20006)"
FT /evidence="ECO:0000305"
FT CONFLICT 2887
FT /note="C -> S (in Ref. 4; CAA20006)"
FT /evidence="ECO:0000305"
FT CONFLICT 3080
FT /note="M -> V (in Ref. 4; CAA20006)"
FT /evidence="ECO:0000305"
FT CONFLICT 3557
FT /note="E -> K (in Ref. 4; CAA20006)"
FT /evidence="ECO:0000305"
FT CONFLICT 3571
FT /note="R -> S (in Ref. 4; CAA20006)"
FT /evidence="ECO:0000305"
FT CONFLICT 3620
FT /note="S -> Y (in Ref. 4; CAA20006)"
FT /evidence="ECO:0000305"
FT CONFLICT 3844
FT /note="K -> E (in Ref. 4; CAA20006)"
FT /evidence="ECO:0000305"
FT CONFLICT 3902
FT /note="E -> V (in Ref. 4; CAA20006)"
FT /evidence="ECO:0000305"
FT CONFLICT 4439
FT /note="T -> A (in Ref. 4; CAA20006)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 5495 AA; 592078 MW; 4CBCB11D44981FB1 CRC64;
MGDQPKATTT ATGGAAGPVP EGDAVMATTN QDALAKGAGD GPAQDAAQEP GQAEHGEPGD
GGDGGDDGAT DAGASSLPPS EIGGRAPLDT ACSDADGGAP SSLAGGIVGP PSPLTGCYLL
IVLGEPHSEE HKDNILQHLL KGFLSWDVSD CHVDLEEELN TITQHAPEGE EARHGERLIQ
YASENLVTEV LIHPQYNTLI QCMRNLLSSF TRHRHIIHAG YTFSGNGSWI LQDGTFSVAD
FSEAFQEHDV QRVIRAYADT ITMNIHCADA GLWHTLPEKA FARQCRIRIN PVDVLDTSSE
CINGFIDYLA PMVMPTSLRE LLETSDVVGN IRFTHPTLYV FPGGQGDAAL FGINGFNMLV
DGGFNRKACF WDFARHLDRL DAVLMTRLNN SNVQGLGAVV SRKRDAHVYP QIGHFFGNVP
DRKGLPSPDG DKDRDPLLID LFERGHGIVS DLKALDLKPQ CCYRNQEPVN LYHKVGHGTL
DMYVISPARD SKEVKEFLQK WHAGDQRLFA ARDSRDFNFP LQNLVSICAL LVWQPANPDD
TITRILFPGS TPDFKIQEGL EKLKHLEFMK HSTCTAKSIA PAIQTVTSTR KSLKSAIEAT
PAPPSASYKT TKFSPVASAA LAVQHPQQQD NKAKEAAAAA AAAAAAAASA ATIARAKADS
MDTDAEPEHE ADPEPADTGD EAAPTEQEPE AETEPEPEHE PEAEQDKDVG EEKKVEVLIM
KPQQATPAVI AASGKDGVDA ASADATPTGK LSKASAKGKA DKPRAEVKPV VRSRIDTKPP
KSMDRKLAKR DEKKSSPTTT PAARAPVAQN AKPKVLSRPA TKSSPSSTPA KSAKEANNRK
VLESKQQAAR VQATSTVSRR VTSTASERRV QQQAEAKTAA TGATQATQRK PISRRPRGVS
PSKRAPAPGS PVKQAKPKAA DLKKTRLDKG GTTDSSLVST PSADEATAAK KLQDLTASQE
LDAEKQRELD DLKEEQEVVR EIEAVFSRDE MKRQQHQQIK AELREMPAEG TGDGENEPDE
EEEYLIIEKE EVEQYTEDSI VEQESSMTKE EEIQKHQRDS QESEKKRKKS AEEEIEAAIA
KVEAAERKAR LEGASARQDE SELDVEPEQS KIKAEVQDII ATAKDIAKSR TEEQLAKPAE
EELSSPTPEE KLSKKTSDTK DDQIGAPVDV LPVNLQESLP EEKFSATIES GATTAPTLPE
DERIPLDQIK EDLVIEEKYV KEETKEAEAI VVATVQTLPE AAPLAIDTIL ASATKDAPKD
ANAEALGELP DSGERVLPMK MTFEAQQNLL RDVIKTPDEV ADLPVHEEAD LGLYEKDSQD
AGAKSISHKE ESAKEEKETD DEKENKVGEI ELGDEPNKVD ISHVLLKESV QEVAEKVVVI
ETTVEKKQEE IVEATTVITQ ENQEDLMEQV KDKEEHEQKI ESGIITEKEA KKSASTPEEK
ETSDITSDDE LPAQLADPTT VPPKSAKDRE DTGSIESPPT IEEAIEVEVQ AKQEAQKPVP
APEEAIKTEK SPLASKETSR PESATGSVKE DTEQTKSKKS PVPSRPESEA KDKKSPFASG
EASRPESVAE SVKDEAGKAE SRRESIAKTH KDESSLDKAK EQESRRESLA ESIKPESGID
EKSALASKEA SRPESVTDKS KEPSRRESIA ESLKAESTKD EKSAPPSKEA SRPGSVVESV
KDETEKSKEP SRRESIAESA KPPIEFREVS RPESVIDGIK DESAKPESRR DSPLASKEAS
RPESVLESVK DEPIKSTEKS RRESVAESFK ADSTKDEKSP LTSKDISRPE SAVENVMDAV
GSAERSQPES VTASRDVSRP ESVAESEKDD TDKPESVVES VIPASDVVEI EKGAADKEKG
VFVSLEIGKP DSPSEVISRP GPVVESVKPE SRRESSTEIV LPCHAEDSKE PSRPESKVEC
LKDESEVLKG STRRESVAES DKSSQPFKET SRPESAVGSM KDESMSKEPS RRESVKDGAA
QSRETSRPAS VAESAKDGAD DLKELSRPES TTQSKEAGSI KDEKSPLASE EASRPASVAE
SVKDEAEKSK EESRRESVAE KSPLPSKEAS RPASVAESIK DEAEKSKEES RRESVAEKSP
LPSKEASRPA SVAESIKDEA EKSKEESRRE SVAEKSPLPS KEASRPASVA ESIKDEAEKS
KEESRRESVA EKSPLPSKEA SRPASVAESI KDEAEKSKEE SRRESVAEKS PLPSKEASRP
ASVAESIKDE AEKSKEESRR ESVAEKSPLP SKEASRPASV AESIKDEAEK SKEESRRESV
AEKSPLPSKE ASRPASVAES IKDEAEKSKE ETRRESVAEK SPLPSKEASR PASVAESIKD
EAEKSKEESR RESAAEKSPL PSKEASRPAS VAESVKDEAD KSKEESRRES MAESGKAQSI
KGDQSPLKEV SRPESVAESV KDDPVKSKEP SRRESVAGSV TADSARDDQS PLESKGASRP
ESVVDSVKDE AEKQESRRES KTESVIPPKA KDDKSPKEVL QPVSMTETIR EDADQPMKPS
QAESRRESIA ESIKASSPRD EKSPLASKEA SRPGSVAESI KYDLDKPQII KDDKSTEHSR
RESLEDKSAV TSEKSVSRPL SVASDHEAAV AIEDDAKSSI SPKDKSRPGF VAETVSSPIE
EATMEFSKIE VVEKSSLALS LQGGSGGKLQ TDSSPVDVAE GDFSHAVASV STVTPTLTKP
AELAQIGAAK TVSSPLDEAL RTPSAPEHIS RADSPAECAS EEIASQDKSP QVLKESSRPA
WVAESKDDAA QLKSSVEDLR SPVASTEISR PASAGETASS PIEEAPKDFA EFEQAEKAVL
PLTIELKGNL PTLSSPVDVA HGDFPQTSTP TSSPTVASVQ PAELSKVDIE KTASSPIDEA
PKSLIGCPAE ERPESPAESA KDAAESVEKS KDASRPPSVV ESTKADSTKG DISPSPESVL
EGPKDDVEKS KESSRPPSVS ASITGDSTKD VSRPASVVES VKDEHDKAES RRESIAKVES
VIDEAGKSDS KSSSQDSQKD EKSTLASKEA SRRESVVESS KDDAEKSESR PESVIASGEP
VPRESKSPLD SKDTSRPGSM VESVTAEDEK SEQQSRRESV AESVKADTKK DGKSQEASRP
SSVDELLKDD DEKQESRRQS ITGSHKAMST MGDESPMDKA DKSKEPSRPE SVAESIKHEN
TKDEESPLGS RRDSVAESIK SDITKGEKSP LPSKEVSRPE SVVGSIKDEK AESRRESVAE
SVKPESSKDA TSAPPSKEHS RPESVLGSLK DEGDKTTSRR VSVADSIKDE KSLLVSQEAS
RPESEAESLK DAAAPSQETS RPESVTESVK DGKSPVASKE ASRPASVAEN AKDSADESKE
QRPESLPQSK AGSIKDEKSP LASKDEAEKS KEESRRESVA EQFPLVSKEV SRPASVAESV
KDEAEKSKEE SPLMSKEASR PASVAGSVKD EAEKSKEESR RESVAEKSPL PSKEASRPAS
VAESVKDEAD KSKEESRRES GAEKSPLASK EASRPASVAE SIKDEAEKSK EESRRESVAE
KSPLPSKEAS RPTSVAESVK DEAEKSKEES RRDSVAEKSP LASKEASRPA SVAESVQDEA
EKSKEESRRE SVAEKSPLAS KEASRPASVA ESIKDEAEKS KEESRRESVA EKSPLASKEA
SRPTSVAESV KDEAEKSKEE SSRDSVAEKS PLASKEASRP ASVAESVQDE AEKSKEESRR
ESVAEKSPLA SKEASRPASV AESVKDDAEK SKEESRRESV AEKSPLASKE ASRPASVAES
VKDEAEKSKE ESRRESVAEK SPLPSKEASR PTSVAESVKD EAEKSKEESR RESVAEKSSL
ASKKASRPAS VAESVKDEAE KSKEESRRES VAEKSPLASK EASRPASVAE SVKDEAEKSK
EESRRESVAE KSPLPSKEAS RPTSVAESVK DEADKSKEES RRESGAEKSP LASMEASRPT
SVAESVKDET EKSKEESRRE SVTEKSPLPS KEASRPTSVA ESVKDEAEKS KEESRRESVA
EKSPLASKES SRPASVAESI KDEAEGTKQE SRRESMPESG KAESIKGDQS SLASKETSRP
DSVVESVKDE TEKPEGSAID KSQVASRPES VAVSAKDEKS PLHSRPESVA DKSPDASKEA
SRSLSVAETA SSPIEEGPRS IADLSLPLNL TGEAKGKLPT LSSPIDVAEG DFLEVKAESS
PRPAVLSKPA EFSQPDTGHT ASTPVDEASP VLEEIEVVEQ HTTSGVGATG ATAETDLLDL
TETKSETVTK QSETTLFETL TSKVESKVEV LESSVKQVEE KVQTSVKQAE TTVTDSLEQL
TKKSSEQLTE IKSVLDTNFE EVAKIVADVA KVLKSDKDIT DIIPDFDERQ LEEKLKSTAD
TEEESDKSTR DEKSLEISVK VEIESEKSSP DQKSGPISIE EKDKIEQSEK AQLRQGILTS
SRPESVASQP ESVPSPSQSA ASHEHKEVEL SESHKAEKSS RPESVASQVS EKDMKTSRPA
SSTSQFSTKE GDEETTESLL HSLTTTETVE TKQMEEKSSF ESVSTSVTKS TVLSSQSTVQ
LREESTSESL SSSLKVEDSS RRESLSSLLA EKGGIATNTS LKEDTSASAS QLEELLVQSE
ECSSESIVSE IQTSIAQKSN KEIKDARETK VTSQFTTTTS SATKDDSLKE TVAEFLATEK
IVSAKEAFST EATKSADDCL KKTTASAVSS TSASQRALFV GTDESRRESL LSQASESRLT
HSDPEDEEPA DDVDERSSVK ESRSKSIATI MMTSIYKPSE DMEPISKLVE EEHEHVEELA
QEVTSTSKTT TLLQSSEQSS TTTSSTSKTG ASRVESITLT QMDQQTSQSQ GDPADRKTPP
TAPVSPGVKA MSSTGSAGSV IGAGAGAVAA GGKCESSAAS IVSSSGPMSP KDISGKSSPG
ALTSESQSIP TPLGRESHTD TPESSPKPTS PFPRVSKDEL KSLEMQHHSQ EQMLAGAAAA
AGAECEGDIP ELHELRGLEC TTALSGSTDK IITTTITTVT KVISADGKEI VTEQKTVTTT
DSSEPDSEKV VVTTTRTTSE SERDQLLPKE VALLRGLYRA STPGSEDDED LLLGSPRSAT
SYELQHSSSG VSKRSDLDAD GDESQDDIPP QYGSEEHSTA RSILLPRTAD PMATSFYGAL
PDSFDVVMKP STEPIPIQGA PSGDSQSSES VESSSQTWAG HKFLDQADKD FQRALEEHVQ
ARGAEVMSSV TAKYSYSPSK AEEMEQIVSG TAERQRFPLS DVQRARVAES GFATVGSVAS
QQQQQEKGGE VEQAVPTTTA VTASTTATAS STGALPKDRL EEWGKPLGLP SPAPLPVEGG
ADIRTTPKKE RRLVATKTRL NNEKNLRRRS ESPNKAGKKP APVYVDLTYV PHNGNSYYAH
VDFFKRVRAR YYVFSGTEPS RQVYDALLEA KQTWEDKELE VTIIPTYDTD VLGYWVAENE
ELLAKHRIDL SPSASRCTIN LQDHETSCSA YRLEF
