FUZZY_DROME
ID FUZZY_DROME Reviewed; 416 AA.
AC O16868;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Protein fuzzy;
GN Name=fuz; Synonyms=fuzzy, fy; ORFNames=CG13396;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=9374400; DOI=10.1242/dev.124.20.4029;
RA Collier S., Gubb D.;
RT "Drosophila tissue polarity requires the cell-autonomous activity of the
RT fuzzy gene, which encodes a novel transmembrane protein.";
RL Development 124:4029-4037(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10924475; DOI=10.1093/genetics/155.4.1799;
RA Collier S., Chan H.Y.E., Toda T., McKimmie C., Johnson G., Adler P.N.,
RA O'Kane C., Ashburner M.;
RT "The Drosophila embargoed gene is required for larval progression and
RT encodes the functional homolog of Schizosaccharomyces Crm1.";
RL Genetics 155:1799-1807(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Testis;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Plays a role in the organization of cell polarity via a
CC planar cell polarity (PCP) cascade. Involved in the development of the
CC hairs on the wings. Specify the correct orientation of the hair by
CC limiting the site of prehair initiation to the distal vertex of the
CC wing cells. Controls wing cell hair number by maintaining the integrity
CC of the cytoskeletal components that direct hair development.
CC {ECO:0000269|PubMed:9374400}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Cytoplasm, cytoskeleton
CC {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in female, but not male.
CC {ECO:0000269|PubMed:9374400}.
CC -!- DEVELOPMENTAL STAGE: Expressed at low levels at all stages of
CC development, with a peak of expression in the embryo and in the 2-day-
CC old pupa. Detected in all wing cells of the 2-day-old pupa.
CC {ECO:0000269|PubMed:9374400}.
CC -!- SIMILARITY: Belongs to the fuzzy family. {ECO:0000305}.
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DR EMBL; AF022891; AAB81830.1; -; mRNA.
DR EMBL; AF179361; AAD55779.1; -; Genomic_DNA.
DR EMBL; AE014134; AAF52671.1; -; Genomic_DNA.
DR EMBL; AY113208; AAM29213.1; -; mRNA.
DR RefSeq; NP_001260250.1; NM_001273321.1.
DR RefSeq; NP_477500.1; NM_058152.3.
DR AlphaFoldDB; O16868; -.
DR BioGRID; 60289; 11.
DR STRING; 7227.FBpp0079317; -.
DR PaxDb; O16868; -.
DR DNASU; 34166; -.
DR EnsemblMetazoa; FBtr0079712; FBpp0079317; FBgn0001084.
DR EnsemblMetazoa; FBtr0331992; FBpp0304314; FBgn0001084.
DR GeneID; 34166; -.
DR KEGG; dme:Dmel_CG13396; -.
DR UCSC; CG13396-RA; d. melanogaster.
DR CTD; 34166; -.
DR FlyBase; FBgn0001084; fy.
DR VEuPathDB; VectorBase:FBgn0001084; -.
DR eggNOG; ENOG502QVMY; Eukaryota.
DR GeneTree; ENSGT00390000010727; -.
DR HOGENOM; CLU_041212_1_0_1; -.
DR InParanoid; O16868; -.
DR OMA; YTDCLLA; -.
DR OrthoDB; 723214at2759; -.
DR PhylomeDB; O16868; -.
DR Reactome; R-DME-450728; Inhibition of actin polymerisation.
DR Reactome; R-DME-5610787; Hedgehog 'off' state.
DR BioGRID-ORCS; 34166; 0 hits in 1 CRISPR screen.
DR ChiTaRS; fy; fly.
DR GenomeRNAi; 34166; -.
DR PRO; PR:O16868; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0001084; Expressed in wing disc and 19 other tissues.
DR ExpressionAtlas; O16868; baseline and differential.
DR Genevisible; O16868; DM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0007163; P:establishment or maintenance of cell polarity; IMP:FlyBase.
DR GO; GO:1905515; P:non-motile cilium assembly; IBA:GO_Central.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR043972; FUZ/MON1/HPS1_longin_1.
DR InterPro; IPR043971; FUZ/MON1/HPS1_longin_2.
DR InterPro; IPR043970; FUZ/MON1/HPS1_longin_3.
DR InterPro; IPR026069; Fuzzy.
DR PANTHER; PTHR13559; PTHR13559; 1.
DR Pfam; PF19036; Fuz_longin_1; 1.
DR Pfam; PF19037; Fuz_longin_2; 1.
DR Pfam; PF19038; Fuz_longin_3; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..416
FT /note="Protein fuzzy"
FT /id="PRO_0000312924"
SQ SEQUENCE 416 AA; 46261 MW; 4515CB282C0D12C9 CRC64;
MSIYLLCLTT NGGLPVFTRK KGECENLPFS TVASLNGFHM FFKSLGIQLE ATTTSKQQPI
QNQAPADAEE WTYIWRDRES ITLIVCGCGV GSEQLLQTLA DLVFGAIGMF ITRAAEMAHA
TLLDRLKKDA KKYVPIVDAI LEAACAGTQL LGYTDCLLAA ENAQLLQCLN EFSGHCGSLF
CCLVVGHRIA VATEGWWDLD TRDRELLLFL LNSSSTMQHD VPVYLPVKSP HIAYRFVSIP
VASNSALCVL CGAENASFRE LHAHAMSAYR NEGNLLAAAE RCVPRSLPEH LEIDGNVLAI
ILINRHTRKS LFTRNLNQSA SVKRIIVGDL QRLDILKKFF DQTMDAVHQF ETQSSSNKTT
LVDQYSCSDY HKCYAHMDEL GNVIFLLFVA AVPSHAMRFL AQRIHANILQ EKSVCW
