ID   FUZZY_DROPS             Reviewed;         416 AA.
AC   Q29NZ8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Protein fuzzy homolog;
GN   Name=fuz; Synonyms=fuzzy, fy; ORFNames=GA12254;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Plays a role in the organization of cell polarity via a
CC       planar cell polarity (PCP) cascade. Involved in the development of the
CC       hairs on the wings. May specify the correct orientation of the hair by
CC       limiting the site of prehair initiation to the distal vertex of the
CC       wing cells. May control wing cell hair number by maintaining the
CC       integrity of the cytoskeletal components that direct hair development
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the fuzzy family. {ECO:0000305}.
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DR   EMBL; CH379058; EAL34495.1; -; Genomic_DNA.
DR   RefSeq; XP_001357426.1; XM_001357390.3.
DR   AlphaFoldDB; Q29NZ8; -.
DR   STRING; 7237.FBpp0279440; -.
DR   PRIDE; Q29NZ8; -.
DR   EnsemblMetazoa; FBtr0281002; FBpp0279440; FBgn0072300.
DR   GeneID; 4817938; -.
DR   KEGG; dpo:Dpse_GA12254; -.
DR   eggNOG; ENOG502QVMY; Eukaryota.
DR   HOGENOM; CLU_041212_1_0_1; -.
DR   InParanoid; Q29NZ8; -.
DR   OMA; YTDCLLA; -.
DR   PhylomeDB; Q29NZ8; -.
DR   ChiTaRS; fy; fly.
DR   Proteomes; UP000001819; Chromosome 4.
DR   Bgee; FBgn0072300; Expressed in female reproductive system and 3 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0007163; P:establishment or maintenance of cell polarity; ISS:UniProtKB.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR043972; FUZ/MON1/HPS1_longin_1.
DR   InterPro; IPR043971; FUZ/MON1/HPS1_longin_2.
DR   InterPro; IPR043970; FUZ/MON1/HPS1_longin_3.
DR   InterPro; IPR026069; Fuzzy.
DR   PANTHER; PTHR13559; PTHR13559; 1.
DR   Pfam; PF19036; Fuz_longin_1; 1.
DR   Pfam; PF19037; Fuz_longin_2; 1.
DR   Pfam; PF19038; Fuz_longin_3; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..416
FT                   /note="Protein fuzzy homolog"
FT                   /id="PRO_0000312925"
SQ   SEQUENCE   416 AA;  46215 MW;  6E6C18630A26F38C CRC64;
     MSIYLLCLTT NGGLPVFTRK KGECDNLPFS TVASLNGFHM FFKSLGIQLE ATTTSKQPLQ
     AQGSGLADPE EWTYIWRDRN AVTLIVCSSG VGSEQLLQSL ADLVFGAIGM FITRASEMAH
     ATLLERLKKD AKKYVPIVDA ILEAACAGTQ LLGYTDCVLT SDNGQLLQCL NEFSGHCGSL
     FCCLVVGHRI AVATEGWWDL DTIDRELLLF LLNSSSTLQH DVPVYLPVKS PNIAYRFVSI
     PVAPNSALCV LCGAENASFR ELHMHAMNAY RNEGNVLAAA ERCVPRSLPE HLDIDGNVLA
     IILINRQSRK SLFTRNLHQS ASAKRIIVGD LQRLDMLKKF FDQTMETIQQ FEANRETTTV
     LMDQYSCSDY HKCYAYADEQ SNVIFLLFVA AVPTHAMRFL AQRVHASILQ EKSVCW