FUZZY_RAT
ID FUZZY_RAT Reviewed; 415 AA.
AC Q3B756;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Protein fuzzy homolog;
GN Name=Fuz;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probable planar cell polarity effector involved in cilium
CC biogenesis. Proposed to function as core component of the CPLANE
CC (ciliogenesis and planar polarity effectors) complex involved in the
CC recruitment of peripheral IFT-A proteins to basal bodies. May regulate
CC protein and membrane transport to the cilium. May regulate the
CC morphogenesis of hair follicles which depends on functional primary
CC cilia (By similarity). {ECO:0000250|UniProtKB:Q3UYI6}.
CC -!- SUBUNIT: Interacts with CPLANE1. Interacts with INTU and WDPCP; FUZ,
CC INTU and WDPCP probably form the core CPLANE (ciliogenesis and planar
CC polarity effectors) complex. {ECO:0000250|UniProtKB:Q3UYI6}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q2HZX7}.
CC Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q2HZX7}. Cytoplasm,
CC cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q3UYI6}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3B756-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3B756-2; Sequence=VSP_029969;
CC -!- SIMILARITY: Belongs to the fuzzy family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AABR03001834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC107809; AAI07810.1; -; mRNA.
DR RefSeq; NP_001032735.1; NM_001037646.1. [Q3B756-2]
DR RefSeq; XP_006229121.1; XM_006229059.3. [Q3B756-1]
DR AlphaFoldDB; Q3B756; -.
DR STRING; 10116.ENSRNOP00000027701; -.
DR PaxDb; Q3B756; -.
DR Ensembl; ENSRNOT00000083336; ENSRNOP00000070688; ENSRNOG00000053084. [Q3B756-1]
DR Ensembl; ENSRNOT00000086890; ENSRNOP00000074982; ENSRNOG00000053084. [Q3B756-2]
DR GeneID; 308577; -.
DR KEGG; rno:308577; -.
DR UCSC; RGD:1310608; rat. [Q3B756-1]
DR CTD; 80199; -.
DR RGD; 1310608; Fuz.
DR eggNOG; ENOG502QVMY; Eukaryota.
DR GeneTree; ENSGT00390000010727; -.
DR HOGENOM; CLU_041212_1_0_1; -.
DR InParanoid; Q3B756; -.
DR OMA; YTDCLLA; -.
DR OrthoDB; 723214at2759; -.
DR PhylomeDB; Q3B756; -.
DR TreeFam; TF324763; -.
DR Reactome; R-RNO-5610787; Hedgehog 'off' state.
DR PRO; PR:Q3B756; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000053084; Expressed in skeletal muscle tissue and 18 other tissues.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0009952; P:anterior/posterior pattern specification; ISO:RGD.
DR GO; GO:0035904; P:aorta development; ISO:RGD.
DR GO; GO:0003279; P:cardiac septum development; ISO:RGD.
DR GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR GO; GO:0060976; P:coronary vasculature development; ISO:RGD.
DR GO; GO:0010172; P:embryonic body morphogenesis; ISS:UniProtKB.
DR GO; GO:0042733; P:embryonic digit morphogenesis; ISO:RGD.
DR GO; GO:0048702; P:embryonic neurocranium morphogenesis; ISO:RGD.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; ISS:UniProtKB.
DR GO; GO:0001736; P:establishment of planar polarity; ISS:UniProtKB.
DR GO; GO:0001942; P:hair follicle development; ISS:UniProtKB.
DR GO; GO:0120223; P:larynx morphogenesis; ISO:RGD.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; ISS:UniProtKB.
DR GO; GO:0030336; P:negative regulation of cell migration; ISS:UniProtKB.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:2000314; P:negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation; ISS:UniProtKB.
DR GO; GO:0090301; P:negative regulation of neural crest formation; ISS:UniProtKB.
DR GO; GO:0001843; P:neural tube closure; ISS:UniProtKB.
DR GO; GO:1905515; P:non-motile cilium assembly; ISS:UniProtKB.
DR GO; GO:0045724; P:positive regulation of cilium assembly; ISS:UniProtKB.
DR GO; GO:0010954; P:positive regulation of protein processing; ISO:RGD.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0008589; P:regulation of smoothened signaling pathway; ISS:UniProtKB.
DR GO; GO:0060021; P:roof of mouth development; ISO:RGD.
DR GO; GO:0021510; P:spinal cord development; ISO:RGD.
DR GO; GO:0021513; P:spinal cord dorsal/ventral patterning; ISO:RGD.
DR GO; GO:0043587; P:tongue morphogenesis; ISO:RGD.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR043972; FUZ/MON1/HPS1_longin_1.
DR InterPro; IPR043971; FUZ/MON1/HPS1_longin_2.
DR InterPro; IPR043970; FUZ/MON1/HPS1_longin_3.
DR InterPro; IPR026069; Fuzzy.
DR PANTHER; PTHR13559; PTHR13559; 1.
DR Pfam; PF19036; Fuz_longin_1; 1.
DR Pfam; PF19037; Fuz_longin_2; 1.
DR Pfam; PF19038; Fuz_longin_3; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell projection; Cilium biogenesis/degradation;
KW Cytoplasm; Cytoskeleton; Developmental protein; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..415
FT /note="Protein fuzzy homolog"
FT /id="PRO_0000312922"
FT VAR_SEQ 165..230
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029969"
SQ SEQUENCE 415 AA; 45407 MW; FE190B7C70B3A62B CRC64;
MGDDGPGSTV HLLCLAASSG VPLFCRSSSG GAPSRQQLPF SVIGSLNGVH MFGQNLDVQL
NSARTEDTTV VWKNFHDSIT LIALSSEEGT SELKLERMLH MVFGAMVLIV GLEELTNIRN
VERLKKELRA SYCLIDSFLG NSELIGDLTQ CVDCVIPPEG SVMQETLSGF AEATGTAFVS
LLVSGRVVAA TDGWWRLGMP EAVLLPWLVG SLPPQAARDY PVYLPHGSPT VPHRLLTLTL
LRGLELCLLC GPRPPLGELD PQLLERWWQP LLEPLRACLP LGPRALPDGF PLHSDILGLL
LLHLELRRCL FTVEPSKDKE PSPEQRRRLL RNFYTLVATT HFPPEPGPAE KQEDTVHPAQ
TPRACYLVLG PGMGWQLVAV QLGLRLLLLM LSPQTPTHGL RSLATHTLQA LTPLL
