ID   FUZZY_XENTR             Reviewed;         418 AA.
AC   Q2HZX7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Protein fuzzy homolog;
DE   AltName: Full=Xfy;
GN   Name=fuz; Synonyms=fuzzy, fy;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=16493421; DOI=10.1038/ng1753;
RA   Park T.J., Haigo S.L., Wallingford J.B.;
RT   "Ciliogenesis defects in embryos lacking inturned or fuzzy function are
RT   associated with failure of planar cell polarity and Hedgehog signaling.";
RL   Nat. Genet. 38:303-311(2006).
RN   [2]
RP   INTERACTION WITH RSG1.
RX   PubMed=19767740; DOI=10.1038/ncb1966;
RA   Gray R.S., Abitua P.B., Wlodarczyk B.J., Szabo-Rogers H.L., Blanchard O.,
RA   Lee I., Weiss G.S., Liu K.J., Marcotte E.M., Wallingford J.B.,
RA   Finnell R.H.;
RT   "The planar cell polarity effector Fuz is essential for targeted membrane
RT   trafficking, ciliogenesis and mouse embryonic development.";
RL   Nat. Cell Biol. 11:1225-1232(2009).
CC   -!- FUNCTION: Probable planar cell polarity effector involved in cilium
CC       biogenesis. Proposed to function as core component of the CPLANE
CC       (ciliogenesis and planar polarity effectors) complex involved in the
CC       recruitment of peripheral IFT-A proteins to basal bodies. May regulate
CC       protein and membrane transport to the cilium. May control the
CC       organization of the apical actin cytoskeleton, which is essential for
CC       the normal orientation of elongating ciliary microtubules.
CC       {ECO:0000269|PubMed:16493421}.
CC   -!- SUBUNIT: Interacts with rsg1 (PubMed:19767740). Interacts with intu and
CC       wdpcp; fuz, intu and wdpcp probably form the core CPLANE (ciliogenesis
CC       and planar polarity effectors) complex (By similarity).
CC       {ECO:0000250|UniProtKB:Q3UYI6, ECO:0000269|PubMed:19767740}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Cytoplasm, cytoskeleton
CC       {ECO:0000305}. Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250|UniProtKB:Q3UYI6}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the neural tube closure, with
CC       strongest expression in the floorplate. Expressed in ciliated epidermal
CC       cells. {ECO:0000269|PubMed:16493421}.
CC   -!- MISCELLANEOUS: Knockdown of fy disrupted Hedgehog signaling and caused
CC       defects in neural tube closure, including exencephaly, spina bifida,
CC       and holoprosencephaly-like features.
CC   -!- SIMILARITY: Belongs to the fuzzy family. {ECO:0000305}.
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DR   EMBL; DQ357248; ABC86957.1; -; mRNA.
DR   RefSeq; NP_001035106.1; NM_001040017.2.
DR   AlphaFoldDB; Q2HZX7; -.
DR   IntAct; Q2HZX7; 1.
DR   PaxDb; Q2HZX7; -.
DR   GeneID; 677733; -.
DR   KEGG; xtr:677733; -.
DR   CTD; 80199; -.
DR   Xenbase; XB-GENE-920644; fuz.
DR   eggNOG; ENOG502QVMY; Eukaryota.
DR   HOGENOM; CLU_041212_1_0_1; -.
DR   InParanoid; Q2HZX7; -.
DR   OMA; YTDCLLA; -.
DR   OrthoDB; 723214at2759; -.
DR   PhylomeDB; Q2HZX7; -.
DR   TreeFam; TF324763; -.
DR   Reactome; R-XTR-5610787; Hedgehog 'off' state.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0010172; P:embryonic body morphogenesis; ISS:UniProtKB.
DR   GO; GO:0048704; P:embryonic skeletal system morphogenesis; ISS:UniProtKB.
DR   GO; GO:0001736; P:establishment of planar polarity; ISS:UniProtKB.
DR   GO; GO:0001843; P:neural tube closure; ISS:UniProtKB.
DR   GO; GO:1905515; P:non-motile cilium assembly; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0008589; P:regulation of smoothened signaling pathway; ISS:UniProtKB.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR043972; FUZ/MON1/HPS1_longin_1.
DR   InterPro; IPR043971; FUZ/MON1/HPS1_longin_2.
DR   InterPro; IPR043970; FUZ/MON1/HPS1_longin_3.
DR   InterPro; IPR026069; Fuzzy.
DR   PANTHER; PTHR13559; PTHR13559; 1.
DR   Pfam; PF19036; Fuz_longin_1; 1.
DR   Pfam; PF19037; Fuz_longin_2; 1.
DR   Pfam; PF19038; Fuz_longin_3; 1.
PE   1: Evidence at protein level;
KW   Cell projection; Cilium biogenesis/degradation; Cytoplasm; Cytoskeleton;
KW   Developmental protein; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..418
FT                   /note="Protein fuzzy homolog"
FT                   /id="PRO_0000312923"
SQ   SEQUENCE   418 AA;  46842 MW;  F1BD8FFCA57C45E7 CRC64;
     MEDSSVFLLC LAASSGVPLY SRSKGSSRQL TFSVIGSLNG VHMFASNQDV LLTSTCTENT
     RVAWRAFHDS ITLIVMSSES GASKLSLNRL LENVFNAMVL VIGLDDLVNI KNVERLKKDL
     RACYRLIDSF LLETEKMGDL TQCVDCVIAY DVPILQECLD NFTQAAESNF GCLMAGGKVV
     VATEKWWRLS SQEVMLLCWL VASLAPHSSR DYPVYLPQGS PTVPHRLLTF QLVPGVDVCV
     LCGPKPSLQK VETELIERFW KPVHDPIKSC LRVQMRSFPA SVPLHHGILG LLLINRDMNK
     SLYTVQAHPM EEMQKTDLKL TLEQRRSALR SFYTLAMSRY FPSERADGKN TLPSEESFQS
     GFSHSAHQCY TISSSCKCYG MKTELHLLFL LLKPEVPTFS MRSIANKTIA AFTKDFPF