ID   FV1_MOUSE               Reviewed;         459 AA.
AC   P70213; P70214;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Friend virus susceptibility protein 1;
GN   Name=Fv1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AKR/J, BALB/cJ, C3H/HeJ, C57BL/6J, and DBA/2J;
RX   PubMed=8752279; DOI=10.1038/382826a0;
RA   Best S., le Tissier P., Towers G., Stoye J.P.;
RT   "Positional cloning of the mouse retrovirus restriction gene Fv1.";
RL   Nature 382:826-829(1996).
RN   [2]
RP   FUNCTION.
RX   PubMed=16474118; DOI=10.1128/jvi.80.5.2100-2105.2006;
RA   Passerini L.D., Keckesova Z., Towers G.J.;
RT   "Retroviral restriction factors Fv1 and TRIM5alpha act independently and
RT   can compete for incoming virus before reverse transcription.";
RL   J. Virol. 80:2100-2105(2006).
CC   -!- FUNCTION: Retroviral restriction factor that prevents infection by
CC       gammaretroviruses. Acts by interacting with the capsid protein ca after
CC       entry of the virus into the cell. This interaction presumably disrupt
CC       the capsid thereby inactivating the viral genome, making it unable to
CC       enter host nucleus and integrate into host genome.
CC       {ECO:0000269|PubMed:16474118}.
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DR   EMBL; X97719; CAA66305.1; -; Genomic_DNA.
DR   EMBL; X97720; CAA66306.1; -; Genomic_DNA.
DR   CCDS; CCDS38964.1; -.
DR   RefSeq; NP_034374.2; NM_010244.3.
DR   AlphaFoldDB; P70213; -.
DR   SMR; P70213; -.
DR   STRING; 10090.ENSMUSP00000092054; -.
DR   iPTMnet; P70213; -.
DR   PhosphoSitePlus; P70213; -.
DR   EPD; P70213; -.
DR   jPOST; P70213; -.
DR   MaxQB; P70213; -.
DR   PaxDb; P70213; -.
DR   PeptideAtlas; P70213; -.
DR   PRIDE; P70213; -.
DR   ProteomicsDB; 273016; -.
DR   Ensembl; ENSMUST00000094481; ENSMUSP00000092054; ENSMUSG00000070583.
DR   GeneID; 14349; -.
DR   KEGG; mmu:14349; -.
DR   UCSC; uc008vtf.1; mouse.
DR   CTD; 14349; -.
DR   MGI; MGI:95595; Fv1.
DR   VEuPathDB; HostDB:ENSMUSG00000070583; -.
DR   eggNOG; ENOG502SDWT; Eukaryota.
DR   GeneTree; ENSGT00940000168197; -.
DR   HOGENOM; CLU_595745_0_0_1; -.
DR   InParanoid; P70213; -.
DR   OrthoDB; 1037842at2759; -.
DR   TreeFam; TF339753; -.
DR   BioGRID-ORCS; 14349; 0 hits in 72 CRISPR screens.
DR   ChiTaRS; Fv1; mouse.
DR   PRO; PR:P70213; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; P70213; protein.
DR   Bgee; ENSMUSG00000070583; Expressed in ventricular zone and 149 other tissues.
DR   Genevisible; P70213; MM.
DR   GO; GO:0005794; C:Golgi apparatus; IDA:MGI.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0009615; P:response to virus; IDA:MGI.
PE   4: Predicted;
KW   Antiviral defense; Host-virus interaction; Reference proteome.
FT   CHAIN           1..459
FT                   /note="Friend virus susceptibility protein 1"
FT                   /id="PRO_0000087389"
FT   REGION          192..269
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        222..246
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        247..269
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         358
FT                   /note="E -> K (in strain: AKR/J, C3H and DBA/2)"
FT   VARIANT         399
FT                   /note="R -> V (in strain: AKR/J, C3H and DBA/2; requires 2
FT                   nucleotide substitutions)"
FT   VARIANT         438..459
FT                   /note="GLTSVGSVGVLSLSPWKHQSNS -> TKL (in strain: AKR/J, C3H
FT                   and DBA/2)"
SQ   SEQUENCE   459 AA;  51997 MW;  B112FD4645EFA489 CRC64;
     MNFPRALAGF SSWLFKPELA EDSPDNDSPD NDTVNPWREL LQKINVADLP DSSFSSGKEL
     NDSVYHTFEH FCKIRDYDAV GELLLAFLDK VTKERDQFRD EISQLRMHIN DLKASKCVLG
     ETLLSYRHRI EVGEKQTEAL IVRLADVQSQ VMCQPARKVS ADKVRALIGK EWDPVTWDGD
     VWEDIDSEGS EEAELPTVLA SPSLSEESGY ALSKERTQQD KADAPQIQSS TSLVTSEPVT
     RPKSLSDLTS QKHRHTNHEL NSLAHSNRQK AKEHARKWIL RVWDNGGRLT ILDQIEFLSL
     GPLSLDSEFN VIARTVEDNG VKSLFDWLAE AWVQRWPTTR ELQSPDTLEW YSIEDGIERL
     RELGMIEWLC VKATCPQWRG PEDVPITRAM RITFVRETRE TWKSFVFSLL CIKDITVGSV
     AAQLHDLIEL SLKPTAAGLT SVGSVGVLSL SPWKHQSNS