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FWA_ARATH
ID   FWA_ARATH               Reviewed;         686 AA.
AC   Q9FVI6; O65608; Q9M0K7;
DT   05-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 2.
DT   03-AUG-2022, entry version 162.
DE   RecName: Full=Homeobox-leucine zipper protein HDG6;
DE   AltName: Full=HD-ZIP protein HDG6;
DE   AltName: Full=Homeobox protein FWA;
DE   AltName: Full=Homeodomain GLABRA 2-like protein 6;
DE   AltName: Full=Homeodomain transcription factor HDG6;
DE   AltName: Full=Protein HOMEODOMAIN GLABROUS 6;
GN   Name=HDG6; Synonyms=FWA, HDGL2-6; OrderedLocusNames=At4g25530;
GN   ORFNames=M7J2.100;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   STRAIN=cv. Landsberg erecta;
RX   PubMed=11090618; DOI=10.1016/s1097-2765(05)00090-0;
RA   Soppe W.J.J., Jacobsen S.E., Alonso-Blanco C., Jackson J.P., Kakutani T.,
RA   Koornneef M., Peeters A.J.M.;
RT   "The late flowering phenotype of fwa mutants is caused by gain-of-function
RT   epigenetic alleles of a homeodomain gene.";
RL   Mol. Cell 6:791-802(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617198; DOI=10.1038/47134;
RA   Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA   Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA   Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA   de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA   Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA   Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA   Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA   Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA   Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA   Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA   Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA   Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA   Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA   Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA   Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA   Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA   Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA   Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA   Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA   Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA   Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA   Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA   Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA   Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA   Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA   Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA   de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA   Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA   Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA   Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA   Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA   Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA   Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA   Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA   Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA   Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA   O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA   Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA   Martienssen R., McCombie W.R.;
RT   "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL   Nature 402:769-777(1999).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   GENE FAMILY.
RX   PubMed=10809443; DOI=10.1023/a:1006368316413;
RA   Tavares R., Aubourg S., Lecharny A., Kreis M.;
RT   "Organization and structural evolution of four multigene families in
RT   Arabidopsis thaliana: AtLCAD, AtLGT, AtMYST and AtHD-GL2.";
RL   Plant Mol. Biol. 42:703-717(2000).
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=16778018; DOI=10.1104/pp.106.077388;
RA   Nakamura M., Katsumata H., Abe M., Yabe N., Komeda Y., Yamamoto K.T.,
RA   Takahashi T.;
RT   "Characterization of the class IV homeodomain-leucine zipper gene family in
RT   Arabidopsis.";
RL   Plant Physiol. 141:1363-1375(2006).
RN   [6]
RP   REGULATION.
RX   PubMed=17921315; DOI=10.1105/tpc.107.052373;
RA   Jiang D., Yang W., He Y., Amasino R.M.;
RT   "Arabidopsis relatives of the human lysine-specific demethylase1 repress
RT   the expression of FWA and FLOWERING LOCUS C and thus promote the floral
RT   transition.";
RL   Plant Cell 19:2975-2987(2007).
RN   [7]
RP   FUNCTION, TISSUE SPECIFICITY, AND INTERACTION WITH FT.
RX   PubMed=17189287; DOI=10.1093/pcp/pcl061;
RA   Ikeda Y., Kobayashi Y., Yamaguchi A., Abe M., Araki T.;
RT   "Molecular basis of late-flowering phenotype caused by dominant epi-alleles
RT   of the FWA locus in Arabidopsis.";
RL   Plant Cell Physiol. 48:205-220(2007).
CC   -!- FUNCTION: Probable transcription factor involved in the regulation of
CC       time of flowering through the photoperiod flowering pathway. May
CC       repress FT. {ECO:0000269|PubMed:17189287}.
CC   -!- SUBUNIT: Interacts with FT. {ECO:0000269|PubMed:17189287}.
CC   -!- INTERACTION:
CC       Q9FVI6; Q9SXZ2: FT; NbExp=2; IntAct=EBI-1393271, EBI-636490;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in siliques, ovules and germinating
CC       seeds. {ECO:0000269|PubMed:17189287}.
CC   -!- DEVELOPMENTAL STAGE: Detected in siliques from 3 days after pollination
CC       until maturity of seeds.
CC   -!- MISCELLANEOUS: Under epigenetic control. In wild-type plant, FWA is
CC       silenced in the sporophyte. The epi-allele fwa mutants (which do not
CC       have a change in the nucleotide sequence of FWA) cause a late-flowering
CC       phenotype due to ectopic FWA expression in sporophytic tissues.
CC       Repression of FWA is dependent on histone H3 'Lys-4' methylation and
CC       cytosine methylation which are partly controlled by the lysine-specific
CC       demthylase 1 (LSD1) homologs, LDL1 and LDL2.
CC   -!- SIMILARITY: Belongs to the HD-ZIP homeobox family. Class IV subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA18173.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CAB81363.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AF178688; AAG09302.1; -; Genomic_DNA.
DR   EMBL; AF243535; AAK28350.1; -; mRNA.
DR   EMBL; AL022197; CAA18173.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AL161563; CAB81363.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002687; AEE85074.1; -; Genomic_DNA.
DR   PIR; A85295; A85295.
DR   RefSeq; NP_567722.1; NM_118685.3.
DR   AlphaFoldDB; Q9FVI6; -.
DR   SMR; Q9FVI6; -.
DR   BioGRID; 13945; 9.
DR   IntAct; Q9FVI6; 2.
DR   STRING; 3702.AT4G25530.1; -.
DR   PaxDb; Q9FVI6; -.
DR   PRIDE; Q9FVI6; -.
DR   ProteomicsDB; 247380; -.
DR   EnsemblPlants; AT4G25530.1; AT4G25530.1; AT4G25530.
DR   GeneID; 828658; -.
DR   Gramene; AT4G25530.1; AT4G25530.1; AT4G25530.
DR   KEGG; ath:AT4G25530; -.
DR   Araport; AT4G25530; -.
DR   TAIR; locus:2131814; AT4G25530.
DR   eggNOG; ENOG502QWUC; Eukaryota.
DR   HOGENOM; CLU_015002_2_1_1; -.
DR   InParanoid; Q9FVI6; -.
DR   OMA; FRYISSP; -.
DR   OrthoDB; 834743at2759; -.
DR   PhylomeDB; Q9FVI6; -.
DR   PRO; PR:Q9FVI6; -.
DR   Proteomes; UP000006548; Chromosome 4.
DR   ExpressionAtlas; Q9FVI6; baseline and differential.
DR   Genevisible; Q9FVI6; AT.
DR   GO; GO:0005634; C:nucleus; IDA:TAIR.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   GO; GO:0042803; F:protein homodimerization activity; IPI:TAIR.
DR   GO; GO:0031047; P:gene silencing by RNA; IMP:TAIR.
DR   GO; GO:0009911; P:positive regulation of flower development; IMP:TAIR.
DR   GO; GO:0006349; P:regulation of gene expression by genomic imprinting; IEP:TAIR.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR042160; GLABRA2/ANL2/PDF2/ATML1-like.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR002913; START_lipid-bd_dom.
DR   PANTHER; PTHR45654; PTHR45654; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF01852; START; 1.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00234; START; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS50848; START; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..686
FT                   /note="Homeobox-leucine zipper protein HDG6"
FT                   /id="PRO_0000048877"
FT   DOMAIN          206..439
FT                   /note="START"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00197"
FT   DNA_BIND        38..98
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          173..202
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          103..170
FT                   /evidence="ECO:0000255"
FT   CONFLICT        311
FT                   /note="L -> I (in Ref. 1; AAG09302/AAK28350)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   686 AA;  76253 MW;  D4E506F66532B184 CRC64;
     MNGQGDLDAV GNIPKPGEAE GDEIDMINDM SGVNDQDGGR MRRTHRRTAY QTQELENFYM
     ENPHPTEEQR YELGQRLNMG VNQVKNWFQN KRNLEKINND HLENVTLREE HDRLLATQDQ
     LRSAMLRSLC NICGKATNCG DTEYEVQKLM AENANLEREI DQFNSRYLSH PKQRMVSTSE
     QAPSSSSNPG INATPVLDFS GGTRTSEKET SIFLNLAITA LRELITLGEV DCPFWMIDPI
     VRSKGVSKIY EKYRSSFNNV TKPPGQIVEA SRAKGLVPMT CVTLVKTLMD TGKWVNVFAP
     IVPVASTHKV LSTGSGGTKS GSLQQIQAEF QVISPLVPKR KVTFIRYCKE IRQGLWVVVD
     VTPTQNPTLL PYGCSKRLPS GLIIDDLSNG YSQVTWIEQA EYNESHIHQL YQPLIGYGIG
     LGAKRWLATL QRHCESLSTL SSTNLTEISP GLSAKGATEI VKLAQRMTLN YYRGITSPSV
     DKWQKIQVEN VAQNMSFMIR KNVNEPGELT GIVLSASTSV WLPVNQHTLF AFISHLSFRH
     EWDILTNDTT MEETIRIQKA KRHGNIISLL KIVNNGMLVL QEIWNDASGA MVVYAPVETN
     SIELVKRGEN SDSVKFLPSG FSIVPDGVNG SYHRGNTGGG CLLTFGLQIL VGINPTAALI
     QGTVKSVETL MAHTIVKIKS ALDLQT
 
 
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