FWCH1_MOUSE
ID FWCH1_MOUSE Reviewed; 673 AA.
AC Q8CI03; E9QKQ2; Q3TH83; Q6ZPN0; Q8C792;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=FLYWCH-type zinc finger-containing protein 1;
GN Name=Flywch1; Synonyms=Kiaa1552;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-666 (ISOFORM 3).
RC STRAIN=C57BL/6J; TISSUE=Heart, and Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 193-673 (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:167-180(2003).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-294, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8CI03-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8CI03-2; Sequence=VSP_030283;
CC Name=3;
CC IsoId=Q8CI03-3; Sequence=VSP_030282;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE40315.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK052314; BAC34932.1; -; mRNA.
DR EMBL; AK168389; BAE40315.1; ALT_FRAME; mRNA.
DR EMBL; AC122821; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC038031; AAH38031.1; -; mRNA.
DR EMBL; AK129391; BAC98201.1; -; mRNA.
DR CCDS; CCDS28463.1; -. [Q8CI03-1]
DR RefSeq; NP_722486.2; NM_153791.2. [Q8CI03-1]
DR RefSeq; XP_006524144.1; XM_006524081.3.
DR RefSeq; XP_006524145.1; XM_006524082.3. [Q8CI03-2]
DR RefSeq; XP_006524146.1; XM_006524083.3. [Q8CI03-2]
DR AlphaFoldDB; Q8CI03; -.
DR SMR; Q8CI03; -.
DR STRING; 10090.ENSMUSP00000040022; -.
DR iPTMnet; Q8CI03; -.
DR PhosphoSitePlus; Q8CI03; -.
DR EPD; Q8CI03; -.
DR jPOST; Q8CI03; -.
DR MaxQB; Q8CI03; -.
DR PaxDb; Q8CI03; -.
DR PeptideAtlas; Q8CI03; -.
DR PRIDE; Q8CI03; -.
DR ProteomicsDB; 271814; -. [Q8CI03-1]
DR ProteomicsDB; 271815; -. [Q8CI03-2]
DR ProteomicsDB; 271816; -. [Q8CI03-3]
DR Antibodypedia; 23928; 57 antibodies from 15 providers.
DR DNASU; 224613; -.
DR Ensembl; ENSMUST00000045517; ENSMUSP00000040022; ENSMUSG00000040097. [Q8CI03-1]
DR Ensembl; ENSMUST00000086325; ENSMUSP00000083505; ENSMUSG00000040097. [Q8CI03-1]
DR GeneID; 224613; -.
DR KEGG; mmu:224613; -.
DR UCSC; uc008ath.1; mouse. [Q8CI03-2]
DR UCSC; uc008ati.1; mouse. [Q8CI03-1]
DR CTD; 84256; -.
DR MGI; MGI:2442638; Flywch1.
DR VEuPathDB; HostDB:ENSMUSG00000040097; -.
DR eggNOG; ENOG502SQTE; Eukaryota.
DR GeneTree; ENSGT00530000064166; -.
DR HOGENOM; CLU_023177_0_0_1; -.
DR InParanoid; Q8CI03; -.
DR OMA; LAQWEGP; -.
DR OrthoDB; 297134at2759; -.
DR TreeFam; TF337169; -.
DR BioGRID-ORCS; 224613; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Flywch1; mouse.
DR PRO; PR:Q8CI03; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q8CI03; protein.
DR Bgee; ENSMUSG00000040097; Expressed in superior frontal gyrus and 247 other tissues.
DR ExpressionAtlas; Q8CI03; baseline and differential.
DR Genevisible; Q8CI03; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0016604; C:nuclear body; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR029279; FLYWCH_N.
DR InterPro; IPR040312; FWCH1/FWCH2.
DR InterPro; IPR007588; Znf_FLYWCH.
DR PANTHER; PTHR31665; PTHR31665; 1.
DR Pfam; PF04500; FLYWCH; 5.
DR Pfam; PF15423; FLYWCH_N; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Isopeptide bond; Metal-binding; Nucleus;
KW Phosphoprotein; Reference proteome; Repeat; Ubl conjugation; Zinc;
KW Zinc-finger.
FT CHAIN 1..673
FT /note="FLYWCH-type zinc finger-containing protein 1"
FT /id="PRO_0000314461"
FT ZN_FING 92..150
FT /note="FLYWCH-type 1"
FT ZN_FING 235..293
FT /note="FLYWCH-type 2"
FT ZN_FING 402..460
FT /note="FLYWCH-type 3"
FT ZN_FING 490..548
FT /note="FLYWCH-type 4"
FT ZN_FING 581..639
FT /note="FLYWCH-type 5"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 147..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 351..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 646..673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..162
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..378
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..399
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 656..673
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 21
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q4VC44"
FT MOD_RES 294
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 339
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q4VC44"
FT CROSSLNK 110
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q4VC44"
FT CROSSLNK 666
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q4VC44"
FT VAR_SEQ 1..287
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_030282"
FT VAR_SEQ 672..673
FT /note="IH -> KSKSKN (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14621295"
FT /id="VSP_030283"
FT CONFLICT 200
FT /note="I -> T (in Ref. 3; AAH38031 and 4; BAC98201)"
FT /evidence="ECO:0000305"
FT CONFLICT 260
FT /note="G -> S (in Ref. 3; AAH38031 and 4; BAC98201)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 673 AA; 77096 MW; EDD0371FB0FBFC9A CRC64;
MPLPEPSEQD CESLRAGQEP SVGARKPQES SNLVPARDKE RPKPTDVASQ ETSSTATLPN
NTLQVAPVKK QGRIIHRKRS RVDAVPPQPL EFLKTPFGGR LLVHKSFLYK QEKAVGDKVY
WKCRQHSELS CRGRAITRGF RVTEMRDHCH PPEKEGLDRK KRHRGRPPSS ALPEGAEVQE
DEVSLWLYPV EPEPTPQPSI ETPEEEQGYR SLALQSLPPK KRPTPGVVRY RPLEFLKTCY
GGTFLVHQSF LYKREKTVGG KVYWTCREHA VHGCRSRAIT QGQRVTVMRS HCHSPDIEGL
QARRQQEKTI KKIQARRIGA GDLEDCDDIE DSLLQGVDSL FYRRGQGTLT LSRSKSKSKS
KSRSKSKSKS RSRSRKRAKK QQESSQEPPE EDQDVDPRGP EFLKTPLGGN FLVYESFLYR
REKVAGEKVY WTCRDQARMG CRSRAITQGR QVTVMRSHCH PPDLLGLETL RQREKRPGPS
QWDGPEGPEF LKTPLGGSFL VYESFLYRRE KATGDKVYWT CRDQARMGCR SRAITQGQRV
MVMRRHCHPP DMGGLEALRQ RENFPNLTHW EGPEPLQPLE FLRTSLGGRF LVYESFLYRK
EKAAGEKVYW MCRDQARLGC RSRAITQGRR VMVMRSHCHP PDLAGLEALR QREKAPSAAK
KKKKKKKKKK GIH
