FWCH2_HUMAN
ID FWCH2_HUMAN Reviewed; 140 AA.
AC Q96CP2;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=FLYWCH family member 2;
GN Name=FLYWCH2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
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DR EMBL; CH471112; EAW85455.1; -; Genomic_DNA.
DR EMBL; BC014089; AAH14089.1; -; mRNA.
DR CCDS; CCDS10482.1; -.
DR RefSeq; NP_001135971.1; NM_001142499.1.
DR RefSeq; NP_001135972.1; NM_001142500.1.
DR RefSeq; NP_612448.1; NM_138439.2.
DR RefSeq; XP_005255135.1; XM_005255078.4.
DR AlphaFoldDB; Q96CP2; -.
DR BioGRID; 125404; 53.
DR IntAct; Q96CP2; 25.
DR MINT; Q96CP2; -.
DR STRING; 9606.ENSP00000380159; -.
DR GlyGen; Q96CP2; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q96CP2; -.
DR PhosphoSitePlus; Q96CP2; -.
DR BioMuta; FLYWCH2; -.
DR EPD; Q96CP2; -.
DR jPOST; Q96CP2; -.
DR MassIVE; Q96CP2; -.
DR MaxQB; Q96CP2; -.
DR PaxDb; Q96CP2; -.
DR PeptideAtlas; Q96CP2; -.
DR PRIDE; Q96CP2; -.
DR ProteomicsDB; 76202; -.
DR TopDownProteomics; Q96CP2; -.
DR Antibodypedia; 52358; 80 antibodies from 13 providers.
DR DNASU; 114984; -.
DR Ensembl; ENST00000293981.10; ENSP00000293981.6; ENSG00000162076.13.
DR Ensembl; ENST00000396958.8; ENSP00000380159.3; ENSG00000162076.13.
DR GeneID; 114984; -.
DR KEGG; hsa:114984; -.
DR MANE-Select; ENST00000396958.8; ENSP00000380159.3; NM_138439.3; NP_612448.1.
DR UCSC; uc002csa.4; human.
DR CTD; 114984; -.
DR GeneCards; FLYWCH2; -.
DR HGNC; HGNC:25178; FLYWCH2.
DR HPA; ENSG00000162076; Low tissue specificity.
DR neXtProt; NX_Q96CP2; -.
DR OpenTargets; ENSG00000162076; -.
DR PharmGKB; PA162388745; -.
DR VEuPathDB; HostDB:ENSG00000162076; -.
DR eggNOG; ENOG502T3Y9; Eukaryota.
DR GeneTree; ENSGT00530000064166; -.
DR HOGENOM; CLU_149723_0_0_1; -.
DR InParanoid; Q96CP2; -.
DR OMA; TRERGCI; -.
DR OrthoDB; 1489033at2759; -.
DR PhylomeDB; Q96CP2; -.
DR TreeFam; TF338211; -.
DR PathwayCommons; Q96CP2; -.
DR SignaLink; Q96CP2; -.
DR BioGRID-ORCS; 114984; 15 hits in 1075 CRISPR screens.
DR ChiTaRS; FLYWCH2; human.
DR GenomeRNAi; 114984; -.
DR Pharos; Q96CP2; Tdark.
DR PRO; PR:Q96CP2; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q96CP2; protein.
DR Bgee; ENSG00000162076; Expressed in tendon of biceps brachii and 179 other tissues.
DR ExpressionAtlas; Q96CP2; baseline and differential.
DR Genevisible; Q96CP2; HS.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR InterPro; IPR029279; FLYWCH_N.
DR InterPro; IPR040312; FWCH1/FWCH2.
DR PANTHER; PTHR31665; PTHR31665; 1.
DR Pfam; PF15423; FLYWCH_N; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..140
FT /note="FLYWCH family member 2"
FT /id="PRO_0000316523"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 84..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..111
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 21
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163"
SQ SEQUENCE 140 AA; 14564 MW; 588F2C07C51B9A77 CRC64;
MPLPEPSEQE GESVKASQEP SPKPGTEVIP AAPRKPRKFS KLVLLTASKD STKVAGAKRK
GVHCVMSLGV PGPATLAKAL LQTHPEAQRA IEAAPQEPEQ KRSRQDPGTD RTEDSGLAAG
PPEAAGENFA PCSVAPGKSL
