FWCH2_MOUSE
ID FWCH2_MOUSE Reviewed; 139 AA.
AC Q9CQE9; Q8R3N7;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=FLYWCH family member 2;
GN Name=Flywch2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
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DR EMBL; AK013108; BAB28653.1; -; mRNA.
DR EMBL; AK019378; BAB31688.1; -; mRNA.
DR EMBL; BC024947; AAH24947.1; -; mRNA.
DR CCDS; CCDS28464.1; -.
DR RefSeq; NP_084074.1; NM_029798.3.
DR RefSeq; XP_017173210.1; XM_017317721.1.
DR AlphaFoldDB; Q9CQE9; -.
DR BioGRID; 218393; 4.
DR STRING; 10090.ENSMUSP00000024704; -.
DR iPTMnet; Q9CQE9; -.
DR PhosphoSitePlus; Q9CQE9; -.
DR MaxQB; Q9CQE9; -.
DR PaxDb; Q9CQE9; -.
DR PRIDE; Q9CQE9; -.
DR ProteomicsDB; 267531; -.
DR Antibodypedia; 52358; 80 antibodies from 13 providers.
DR Ensembl; ENSMUST00000024704; ENSMUSP00000024704; ENSMUSG00000023911.
DR GeneID; 76917; -.
DR KEGG; mmu:76917; -.
DR UCSC; uc008atl.1; mouse.
DR CTD; 114984; -.
DR MGI; MGI:1924167; Flywch2.
DR VEuPathDB; HostDB:ENSMUSG00000023911; -.
DR eggNOG; ENOG502T3Y9; Eukaryota.
DR GeneTree; ENSGT00530000064166; -.
DR HOGENOM; CLU_149723_0_0_1; -.
DR InParanoid; Q9CQE9; -.
DR OMA; TRERGCI; -.
DR OrthoDB; 1489033at2759; -.
DR TreeFam; TF338211; -.
DR BioGRID-ORCS; 76917; 1 hit in 70 CRISPR screens.
DR ChiTaRS; Flywch2; mouse.
DR PRO; PR:Q9CQE9; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q9CQE9; protein.
DR Bgee; ENSMUSG00000023911; Expressed in internal carotid artery and 181 other tissues.
DR ExpressionAtlas; Q9CQE9; baseline and differential.
DR Genevisible; Q9CQE9; MM.
DR InterPro; IPR029279; FLYWCH_N.
DR InterPro; IPR040312; FWCH1/FWCH2.
DR PANTHER; PTHR31665; PTHR31665; 1.
DR Pfam; PF15423; FLYWCH_N; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..139
FT /note="FLYWCH family member 2"
FT /id="PRO_0000316525"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 86..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..109
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 6
FT /note="P -> A (in Ref. 2; AAH24947)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 139 AA; 14458 MW; 9658585A59EF8907 CRC64;
MPQPKPSEQE GESMKASQEP APQPGTDVVP AAPRKPRKFS KLVLLTASKD SAKVAGAKRK
GVHCIMSLGV PGPATLAKAL LKTHPEAQRA IEATPLEPEQ KRSKQNLDSD GPEDNGGSGV
SSSSSEETTV LPEAPSTSP
