ID   FWDA_METJA              Reviewed;         567 AA.
AC   Q58569;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Protein FwdA;
GN   Name=fwdA; OrderedLocusNames=MJ1169;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       FwdA/FmdA family. {ECO:0000305}.
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DR   EMBL; L77117; AAB99171.1; -; Genomic_DNA.
DR   PIR; H64445; H64445.
DR   RefSeq; WP_010870682.1; NC_000909.1.
DR   AlphaFoldDB; Q58569; -.
DR   SMR; Q58569; -.
DR   STRING; 243232.MJ_1169; -.
DR   DNASU; 1452067; -.
DR   EnsemblBacteria; AAB99171; AAB99171; MJ_1169.
DR   GeneID; 1452067; -.
DR   KEGG; mja:MJ_1169; -.
DR   eggNOG; arCOG04461; Archaea.
DR   HOGENOM; CLU_035587_0_0_2; -.
DR   InParanoid; Q58569; -.
DR   OMA; GEKMDIC; -.
DR   OrthoDB; 8152at2157; -.
DR   PhylomeDB; Q58569; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0016810; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; IEA:InterPro.
DR   CDD; cd01304; FMDH_A; 1.
DR   Gene3D; 2.30.40.10; -; 2.
DR   InterPro; IPR013108; Amidohydro_3.
DR   InterPro; IPR012027; Formylmethanofuran_DH_asu.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   Pfam; PF07969; Amidohydro_3; 1.
DR   PIRSF; PIRSF006453; FwdA; 1.
DR   SUPFAM; SSF51338; SSF51338; 2.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   TIGRFAMs; TIGR03121; one_C_dehyd_A; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..567
FT                   /note="Protein FwdA"
FT                   /id="PRO_0000087391"
SQ   SEQUENCE   567 AA;  63411 MW;  EB6B1A37DFB4737C CRC64;
     MEYIIKNGIV YDPLNGINGE KMDICVKDGK IVESVSDNAK VIDASGCVVM PGGIDSHSHV
     AGAKVNVGRI FRPEDSKREI YAKKGLRTGT GFSVPSTYKT GYQYSEMGYT TVIEAAMPPL
     IARHTHEEFM ETPQIDKAAM PLFGNNWMVL EYLKEGDIKA CAAFVAWLLK AVKGFAIKIV
     NPGGTEAWGW GKNVHSLDDP VPYFDITPRE IVRGLAEVNE LLGLPHSIHV HPNNLGHPGN
     WETTLETMKC VEGVEAKPRV GERETSYYNT HCQFHSYGGT SWKDFESKAI EIAEYVNKSK
     HVVIDVGQVT LDETTTMTAD GPMEYDLHMT NGLKWANCDV ELETGSGVVP FIYSPKGPVY
     AVQWAIGLEL FLNTNTDKVL LTTDHPNAGP FTRYPRVIAW LMSKKYRDEW LYNKVHKWAQ
     QRSHVADADK EYDLYEIAKI TRANQAKVLG LSETKGHLGV GAEADIAIYA IDPEEKDGKK
     IEKAFRYAKY VLKGGEVVVK DGNVVKEVFG DTIYVDVQVG EDLMNEVLKD VGEKFRRYYS
     VNLENYPVSD EYANSWRVIK IDATDIN