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FWDC_METJA
ID   FWDC_METJA              Reviewed;         273 AA.
AC   Q58571;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Tungsten-containing formylmethanofuran dehydrogenase 2 subunit C;
DE            EC=1.2.7.12 {ECO:0000250|UniProtKB:Q48943};
DE   AltName: Full=Tungsten-containing formylmethanofuran dehydrogenase II subunit C;
GN   Name=fwdC; OrderedLocusNames=MJ1171;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- FUNCTION: Catalyzes the reversible oxidation of CO(2) and methanofuran
CC       (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
CC       {ECO:0000250|UniProtKB:Q48943}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin]
CC         = CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin];
CC         Xref=Rhea:RHEA:19841, Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:57727,
CC         ChEBI:CHEBI:58151; EC=1.2.7.12;
CC         Evidence={ECO:0000250|UniProtKB:Q48943};
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC       methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 1/3.
CC   -!- SUBUNIT: This enzyme is composed of six subunits FwdA, FwdC, FwdD,
CC       FwdE, FwdF and FwdG. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FwdC/FmdC family. {ECO:0000305}.
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DR   EMBL; L77117; AAB99173.1; -; Genomic_DNA.
DR   PIR; B64446; B64446.
DR   RefSeq; WP_010870684.1; NC_000909.1.
DR   AlphaFoldDB; Q58571; -.
DR   SMR; Q58571; -.
DR   STRING; 243232.MJ_1171; -.
DR   EnsemblBacteria; AAB99173; AAB99173; MJ_1171.
DR   GeneID; 1452069; -.
DR   KEGG; mja:MJ_1171; -.
DR   eggNOG; arCOG00097; Archaea.
DR   HOGENOM; CLU_072248_0_0_2; -.
DR   InParanoid; Q58571; -.
DR   OMA; VNGDAGM; -.
DR   OrthoDB; 72252at2157; -.
DR   PhylomeDB; Q58571; -.
DR   UniPathway; UPA00640; UER00692.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0018493; F:formylmethanofuran dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR   CDD; cd00980; FwdC/FmdC; 1.
DR   Gene3D; 2.160.20.60; -; 2.
DR   InterPro; IPR017550; Formylmethanofuran_DH_suC.
DR   InterPro; IPR002489; Glu_synth_asu_C.
DR   InterPro; IPR036485; Glu_synth_asu_C_sf.
DR   Pfam; PF01493; GXGXG; 1.
DR   SUPFAM; SSF69336; SSF69336; 1.
DR   TIGRFAMs; TIGR03122; one_C_dehyd_C; 1.
PE   3: Inferred from homology;
KW   Methanogenesis; Oxidoreductase; Reference proteome; Repeat.
FT   CHAIN           1..273
FT                   /note="Tungsten-containing formylmethanofuran dehydrogenase
FT                   2 subunit C"
FT                   /id="PRO_0000144194"
FT   REPEAT          78..90
FT                   /note="1"
FT   REPEAT          97..109
FT                   /note="2"
FT   REPEAT          116..128
FT                   /note="3"
FT   REPEAT          142..154
FT                   /note="4"
FT   REPEAT          161..173
FT                   /note="5"
FT   REPEAT          180..192
FT                   /note="6"
FT   REPEAT          199..211
FT                   /note="7"
FT   REGION          78..211
FT                   /note="7 X 13 AA repeats of [GW]-X-X-[MQ]-X-X-G-X-[IL]-X-
FT                   [IV]-X-G"
SQ   SEQUENCE   273 AA;  29461 MW;  B34219D170D9C1AD CRC64;
     MKELILTLQK EIIVPVEMDK VLPEVIENMS LEEIKNIELV QGRKRIKVAD IFDVELNDIE
     GEPRIVIKNS SPKLKYIGSK MTKGEIVVEG DAGMYVGAEM KGGKIVVNGN AESWAGQNMK
     GGELLIKGNA GDYVGSAYRG DWRGMSGGTI IVEGNAGNEI GEFMSKGLIH IKGNVGIMAG
     IHQNGGIIII DGDVDVRVGG EMKAGAIVVY GKVEEILPSF KFEGIVENPV IKLSKKDAGT
     PIAGTFYKFS GDYVYNKPKG QLYISVDSNP DLI
 
 
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