ID   FWDC_METMI              Reviewed;         272 AA.
AC   P0CW42; O31112;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Tungsten-containing formylmethanofuran dehydrogenase 2 subunit C;
DE            EC=1.2.7.12 {ECO:0000250|UniProtKB:Q48943};
DE   AltName: Full=Tungsten-containing formylmethanofuran dehydrogenase II subunit C;
GN   Name=fwdC;
OS   Methanococcus maripaludis (Methanococcus deltae).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=39152;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 43000 / DSM 2067 / JCM 10722 / JJ;
RA   Yu J.-P., Whitman W.B.;
RL   Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the reversible oxidation of CO(2) and methanofuran
CC       (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
CC       {ECO:0000250|UniProtKB:Q48943}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin]
CC         = CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin];
CC         Xref=Rhea:RHEA:19841, Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:57727,
CC         ChEBI:CHEBI:58151; EC=1.2.7.12;
CC         Evidence={ECO:0000250|UniProtKB:Q48943};
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC       methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 1/3.
CC   -!- SUBUNIT: This enzyme is composed of seven subunits fwdA (65 kDa), fwdB
CC       (53 kDa), fwdC (31 kDa), fwdD (15 kDa), fwdE, fwdF and fwdG.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FwdC/FmdC family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF029842; AAB82591.1; -; Genomic_DNA.
DR   AlphaFoldDB; P0CW42; -.
DR   SMR; P0CW42; -.
DR   UniPathway; UPA00640; UER00692.
DR   GO; GO:0018493; F:formylmethanofuran dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR   CDD; cd00980; FwdC/FmdC; 1.
DR   Gene3D; 2.160.20.60; -; 1.
DR   InterPro; IPR017550; Formylmethanofuran_DH_suC.
DR   InterPro; IPR002489; Glu_synth_asu_C.
DR   InterPro; IPR036485; Glu_synth_asu_C_sf.
DR   Pfam; PF01493; GXGXG; 1.
DR   SUPFAM; SSF69336; SSF69336; 1.
DR   TIGRFAMs; TIGR03122; one_C_dehyd_C; 1.
PE   3: Inferred from homology;
KW   Methanogenesis; Oxidoreductase; Repeat.
FT   CHAIN           1..272
FT                   /note="Tungsten-containing formylmethanofuran dehydrogenase
FT                   2 subunit C"
FT                   /id="PRO_0000144195"
FT   REPEAT          77..89
FT                   /note="1"
FT   REPEAT          96..108
FT                   /note="2"
FT   REPEAT          115..127
FT                   /note="3"
FT   REPEAT          141..153
FT                   /note="4"
FT   REPEAT          160..172
FT                   /note="5"
FT   REPEAT          179..191
FT                   /note="6"
FT   REPEAT          198..210
FT                   /note="7"
FT   REGION          77..210
FT                   /note="7 X 13 AA repeats of [GW]-X-X-[MLP]-X-X-G-X-[IL]-X-
FT                   [IV]-X-G"
SQ   SEQUENCE   272 AA;  29174 MW;  50912BD8B47A4BF0 CRC64;
     MNELILNLKG DVSVPVEMDK IIPEKIQEMS LEKISGIELI QGNKTAKVSE IFDVELKESP
     VSKVTINNCC KKVKRIGEKM TSGEIVVNGD AGMYVGVEMK GGKITVNGDA ESWVGQNLKG
     GEIIINGNAE NYVGSAYRGD WRGMSGGKIT ITGTAGSELG EYLKGGTIVI KGNTKIMPGI
     HPNGGMIIIE GDIEGRAGGE MMKGAIVVYG KTLEPLPSFK FEGIVEDPLV KLFKKDAGTQ
     LKGTFIKFSG DYVNTKPKGQ LYAAIENNKN LI