ID   FWDC_METMP              Reviewed;         272 AA.
AC   P0CW43; O31112;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Tungsten-containing formylmethanofuran dehydrogenase 2 subunit C;
DE            EC=1.2.7.12 {ECO:0000250|UniProtKB:Q48943};
DE   AltName: Full=Tungsten-containing formylmethanofuran dehydrogenase II subunit C;
GN   Name=fwdC; OrderedLocusNames=MMP1249;
OS   Methanococcus maripaludis (strain S2 / LL).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=267377;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S2 / LL;
RX   PubMed=15466049; DOI=10.1128/jb.186.20.6956-6969.2004;
RA   Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J.,
RA   Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M.,
RA   Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A.,
RA   Moore B.C., Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D.,
RA   Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W.,
RA   Olson M.V., Leigh J.A.;
RT   "Complete genome sequence of the genetically tractable hydrogenotrophic
RT   methanogen Methanococcus maripaludis.";
RL   J. Bacteriol. 186:6956-6969(2004).
CC   -!- FUNCTION: Catalyzes the reversible oxidation of CO(2) and methanofuran
CC       (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
CC       {ECO:0000250|UniProtKB:Q48943}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin]
CC         = CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin];
CC         Xref=Rhea:RHEA:19841, Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:57727,
CC         ChEBI:CHEBI:58151; EC=1.2.7.12;
CC         Evidence={ECO:0000250|UniProtKB:Q48943};
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC       methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 1/3.
CC   -!- SUBUNIT: This enzyme is composed of seven subunits fwdA (65 kDa), fwdB
CC       (53 kDa), fwdC (31 kDa), fwdD (15 kDa), fwdE, fwdF and fwdG.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FwdC/FmdC family. {ECO:0000305}.
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DR   EMBL; BX950229; CAF30805.1; -; Genomic_DNA.
DR   RefSeq; WP_011171193.1; NC_005791.1.
DR   AlphaFoldDB; P0CW43; -.
DR   SMR; P0CW43; -.
DR   STRING; 267377.MMP1249; -.
DR   EnsemblBacteria; CAF30805; CAF30805; MMP1249.
DR   GeneID; 2762780; -.
DR   KEGG; mmp:MMP1249; -.
DR   PATRIC; fig|267377.15.peg.1282; -.
DR   eggNOG; arCOG00097; Archaea.
DR   HOGENOM; CLU_072248_0_0_2; -.
DR   OMA; VNGDAGM; -.
DR   OrthoDB; 72252at2157; -.
DR   BioCyc; MMAR267377:MMP_RS06425-MON; -.
DR   UniPathway; UPA00640; UER00692.
DR   Proteomes; UP000000590; Chromosome.
DR   GO; GO:0018493; F:formylmethanofuran dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR   CDD; cd00980; FwdC/FmdC; 1.
DR   Gene3D; 2.160.20.60; -; 1.
DR   InterPro; IPR017550; Formylmethanofuran_DH_suC.
DR   InterPro; IPR002489; Glu_synth_asu_C.
DR   InterPro; IPR036485; Glu_synth_asu_C_sf.
DR   Pfam; PF01493; GXGXG; 1.
DR   SUPFAM; SSF69336; SSF69336; 1.
DR   TIGRFAMs; TIGR03122; one_C_dehyd_C; 1.
PE   3: Inferred from homology;
KW   Methanogenesis; Oxidoreductase; Reference proteome; Repeat.
FT   CHAIN           1..272
FT                   /note="Tungsten-containing formylmethanofuran dehydrogenase
FT                   2 subunit C"
FT                   /id="PRO_0000408198"
FT   REPEAT          77..89
FT                   /note="1"
FT   REPEAT          96..108
FT                   /note="2"
FT   REPEAT          115..127
FT                   /note="3"
FT   REPEAT          141..153
FT                   /note="4"
FT   REPEAT          160..172
FT                   /note="5"
FT   REPEAT          179..191
FT                   /note="6"
FT   REPEAT          198..210
FT                   /note="7"
FT   REGION          77..210
FT                   /note="7 X 13 AA repeats of [GW]-X-X-[MLP]-X-X-G-X-[IL]-X-
FT                   [IV]-X-G"
SQ   SEQUENCE   272 AA;  29187 MW;  F87AA3DE97D34DC0 CRC64;
     MNELILNLKG DVSVPVEMDK ILPEKIQEMS LEEISGIELI QGNKTAKVSE IFDVELKESD
     VAKVTINNCC KKVKRIGEKM TSGEIVVNGD AGMYIGVEMK GGKITVNGDA ESWVGQNLKG
     GEIIINGNAE NYVGSAYRGD WRGMSGGKIT ITGNAGSELG EYLKGGTIVI KGNTKIMPGI
     HQNGGMIIIE GDIEGRAGGE MMKGAIVVYG KILEPLPSFK FEGIVEDPLV KLSKKDAGTQ
     LKGTFIKFSG DYVNTKPKGQ LYAAIENNKN LI