ID   FWDC_METTH              Reviewed;         270 AA.
AC   O27600;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 123.
DE   RecName: Full=Tungsten-containing formylmethanofuran dehydrogenase 2 subunit C;
DE            EC=1.2.7.12 {ECO:0000250|UniProtKB:Q48943};
DE   AltName: Full=Tungsten-containing formylmethanofuran dehydrogenase II subunit C;
GN   Name=fwdC; OrderedLocusNames=MTH_1558;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- FUNCTION: Catalyzes the reversible oxidation of CO(2) and methanofuran
CC       (MFR) to N-formylmethanofuran (CHO-MFR). Can only oxidize
CC       formylmethanofuran. This enzyme is oxygen-labile.
CC       {ECO:0000250|UniProtKB:Q48943}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin]
CC         = CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin];
CC         Xref=Rhea:RHEA:19841, Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:57727,
CC         ChEBI:CHEBI:58151; EC=1.2.7.12;
CC         Evidence={ECO:0000250|UniProtKB:Q48943};
CC   -!- ACTIVITY REGULATION: Not inactivated by cyanide.
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC       methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 1/3.
CC   -!- SUBUNIT: This enzyme is composed of seven subunits FwdA (65 kDa), FwdB
CC       (53 kDa), FwdC (31 kDa), FwdD (15 kDa), FwdE, FwdF and FwdG.
CC       {ECO:0000250}.
CC   -!- INDUCTION: By growth on tungsten or molybdenum under anaerobic
CC       conditions.
CC   -!- SIMILARITY: Belongs to the FwdC/FmdC family. {ECO:0000305}.
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DR   EMBL; AE000666; AAB86032.1; -; Genomic_DNA.
DR   PIR; H69074; H69074.
DR   RefSeq; WP_010877167.1; NC_000916.1.
DR   AlphaFoldDB; O27600; -.
DR   SMR; O27600; -.
DR   IntAct; O27600; 2.
DR   STRING; 187420.MTH_1558; -.
DR   TCDB; 3.D.8.1.1; the na(+)- or h(+)-pumping formyl methanofuran dehydrogenase (fmf-dh) family.
DR   EnsemblBacteria; AAB86032; AAB86032; MTH_1558.
DR   GeneID; 1471827; -.
DR   KEGG; mth:MTH_1558; -.
DR   PATRIC; fig|187420.15.peg.1521; -.
DR   HOGENOM; CLU_072248_0_0_2; -.
DR   OMA; VNGDAGM; -.
DR   UniPathway; UPA00640; UER00692.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0018493; F:formylmethanofuran dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR   CDD; cd00980; FwdC/FmdC; 1.
DR   Gene3D; 2.160.20.60; -; 2.
DR   InterPro; IPR017550; Formylmethanofuran_DH_suC.
DR   InterPro; IPR036485; Glu_synth_asu_C_sf.
DR   SUPFAM; SSF69336; SSF69336; 1.
DR   TIGRFAMs; TIGR03122; one_C_dehyd_C; 1.
PE   2: Evidence at transcript level;
KW   Methanogenesis; Oxidoreductase; Reference proteome; Repeat.
FT   CHAIN           1..270
FT                   /note="Tungsten-containing formylmethanofuran dehydrogenase
FT                   2 subunit C"
FT                   /id="PRO_0000144196"
FT   REPEAT          80..92
FT                   /note="1"
FT   REPEAT          99..111
FT                   /note="2"
FT   REPEAT          118..130
FT                   /note="3"
FT   REPEAT          144..156
FT                   /note="4"
FT   REPEAT          163..175
FT                   /note="5"
FT   REPEAT          182..194
FT                   /note="6"
FT   REPEAT          201..213
FT                   /note="7"
FT   REGION          80..213
FT                   /note="7 X 13 AA repeats of [GW]-X-X-M-X-X-G-X-[IL]-X-[IV]-
FT                   X-G"
SQ   SEQUENCE   270 AA;  28641 MW;  043A9FFBBA554D36 CRC64;
     MSEIILTPKE QPEVPLEAPN IKPDVFAGKS IDEIRNIQIM HGNEVVKLGD FFEVSGEPAD
     SAADIKIIID GDVYNTKRIG QDMTAGEILV KGNVNMYVGA GMKGGKITVE GNAKSWAGQD
     MRGGELEIFG DAGDYVGSSY RGDWRGMSGG VITVHGNAGN EIGEYMNGGK IIIKGDVNIM
     PGIHMNNGLI IIEGNAVARV GGEMAGGTIV VKGMIEEFLP GFKYLGVEKD IEVNGETFPG
     AYYKFEGDHA IKGAKGMVYA AVGCNGHIEP