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FWDC_METWO
ID   FWDC_METWO              Reviewed;         270 AA.
AC   O74031;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Tungsten-containing formylmethanofuran dehydrogenase 2 subunit C;
DE            EC=1.2.7.12 {ECO:0000250|UniProtKB:Q48943};
DE   AltName: Full=Tungsten-containing formylmethanofuran dehydrogenase II subunit C;
GN   Name=fwdC;
OS   Methanothermobacter wolfeii (Methanobacterium wolfei).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=145261;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9818358; DOI=10.1007/s002030050658;
RA   Hochheimer A., Hedderich R., Thauer R.K.;
RT   "The formylmethanofuran dehydrogenase isoenzymes in Methanobacterium wolfei
RT   and Methanobacterium thermoautotrophicum: induction of the molybdenum
RT   isoenzyme by molybdate and constitutive synthesis of the tungsten
RT   isoenzyme.";
RL   Arch. Microbiol. 170:389-393(1998).
CC   -!- FUNCTION: Catalyzes the reversible oxidation of CO(2) and methanofuran
CC       (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
CC       {ECO:0000250|UniProtKB:Q48943}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin]
CC         = CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin];
CC         Xref=Rhea:RHEA:19841, Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:57727,
CC         ChEBI:CHEBI:58151; EC=1.2.7.12;
CC         Evidence={ECO:0000250|UniProtKB:Q48943};
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC       methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 1/3.
CC   -!- SUBUNIT: This enzyme is composed of six subunits FwdA, FwdB, FwdC,
CC       FwdD, FwdF and FwdG. {ECO:0000250}.
CC   -!- INDUCTION: By growth on tungsten or molybdenum under anaerobic
CC       conditions.
CC   -!- SIMILARITY: Belongs to the FwdC/FmdC family. {ECO:0000305}.
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DR   EMBL; AJ009688; CAA08784.1; -; Genomic_DNA.
DR   PDB; 5T5I; X-ray; 1.90 A; C/K=1-270.
DR   PDB; 5T5M; X-ray; 2.50 A; C=1-270.
DR   PDBsum; 5T5I; -.
DR   PDBsum; 5T5M; -.
DR   AlphaFoldDB; O74031; -.
DR   SMR; O74031; -.
DR   STRING; 145261.MWSIV6_0099; -.
DR   UniPathway; UPA00640; UER00692.
DR   GO; GO:0018493; F:formylmethanofuran dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR   CDD; cd00980; FwdC/FmdC; 1.
DR   Gene3D; 2.160.20.60; -; 1.
DR   InterPro; IPR017550; Formylmethanofuran_DH_suC.
DR   InterPro; IPR036485; Glu_synth_asu_C_sf.
DR   SUPFAM; SSF69336; SSF69336; 1.
DR   TIGRFAMs; TIGR03122; one_C_dehyd_C; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Methanogenesis; Oxidoreductase; Repeat.
FT   CHAIN           1..270
FT                   /note="Tungsten-containing formylmethanofuran dehydrogenase
FT                   2 subunit C"
FT                   /id="PRO_0000144198"
FT   REPEAT          80..92
FT                   /note="1"
FT   REPEAT          99..111
FT                   /note="2"
FT   REPEAT          118..130
FT                   /note="3"
FT   REPEAT          144..156
FT                   /note="4"
FT   REPEAT          163..175
FT                   /note="5"
FT   REPEAT          182..194
FT                   /note="6"
FT   REPEAT          201..213
FT                   /note="7"
FT   REGION          80..213
FT                   /note="7 X 13 AA repeats of [GW]-X-X-M-X-X-G-X-[IL]-X-[IV]-
FT                   X-G"
FT   STRAND          3..8
FT                   /evidence="ECO:0007829|PDB:5T5I"
FT   HELIX           23..26
FT                   /evidence="ECO:0007829|PDB:5T5I"
FT   HELIX           31..35
FT                   /evidence="ECO:0007829|PDB:5T5I"
FT   STRAND          38..41
FT                   /evidence="ECO:0007829|PDB:5T5I"
FT   STRAND          44..47
FT                   /evidence="ECO:0007829|PDB:5T5I"
FT   HELIX           48..50
FT                   /evidence="ECO:0007829|PDB:5T5I"
FT   STRAND          52..56
FT                   /evidence="ECO:0007829|PDB:5T5I"
FT   HELIX           62..64
FT                   /evidence="ECO:0007829|PDB:5T5I"
FT   STRAND          66..69
FT                   /evidence="ECO:0007829|PDB:5T5I"
FT   TURN            79..82
FT                   /evidence="ECO:0007829|PDB:5T5I"
FT   STRAND          85..92
FT                   /evidence="ECO:0007829|PDB:5T5I"
FT   TURN            98..101
FT                   /evidence="ECO:0007829|PDB:5T5I"
FT   STRAND          104..111
FT                   /evidence="ECO:0007829|PDB:5T5I"
FT   TURN            115..120
FT                   /evidence="ECO:0007829|PDB:5T5I"
FT   STRAND          123..130
FT                   /evidence="ECO:0007829|PDB:5T5I"
FT   STRAND          151..156
FT                   /evidence="ECO:0007829|PDB:5T5I"
FT   TURN            162..165
FT                   /evidence="ECO:0007829|PDB:5T5I"
FT   STRAND          167..175
FT                   /evidence="ECO:0007829|PDB:5T5I"
FT   STRAND          177..179
FT                   /evidence="ECO:0007829|PDB:5T5I"
FT   TURN            181..184
FT                   /evidence="ECO:0007829|PDB:5T5I"
FT   STRAND          187..194
FT                   /evidence="ECO:0007829|PDB:5T5I"
FT   STRAND          196..198
FT                   /evidence="ECO:0007829|PDB:5T5I"
FT   TURN            200..203
FT                   /evidence="ECO:0007829|PDB:5T5I"
FT   STRAND          208..213
FT                   /evidence="ECO:0007829|PDB:5T5I"
FT   STRAND          223..233
FT                   /evidence="ECO:0007829|PDB:5T5I"
FT   STRAND          236..247
FT                   /evidence="ECO:0007829|PDB:5T5I"
FT   STRAND          256..261
FT                   /evidence="ECO:0007829|PDB:5T5I"
FT   HELIX           262..264
FT                   /evidence="ECO:0007829|PDB:5T5I"
FT   TURN            266..268
FT                   /evidence="ECO:0007829|PDB:5T5I"
SQ   SEQUENCE   270 AA;  28660 MW;  BB1061CBDF53061B CRC64;
     MSEIILTPKE QPEVPLEAPN IKPDVFAGKS IDEIKNIQIM HGNEVVKLGD FFEVSGEPAD
     APEDIKIIID GDVYNTKRIG QEMTAGEIIV RGNVNMYVGA GMKGGKITVE GNAGSWAGQD
     MRGGEIEILG DADDYVGSSY RGDWRGMSGG TITVHGNADN EIGEYMNGGK IIIKGDVNIM
     PGIHMNNGLI IIEGNVVARA GGEMAGGTIV VKGMMQEFLA GFKYLGVEKD IELMVKNSPG
     AFYKFEGDHA IKGAKGIVYA AVGCNGHIAP
 
 
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