FX1AB_DANRE
ID FX1AB_DANRE Reviewed; 629 AA.
AC A3RK75;
DT 03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Forkhead box protein O1-B;
GN Name=foxo1b; Synonyms=foxO1a.2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX PubMed=17993506; DOI=10.1093/hmg/ddm326;
RA Berry F.B., Skarie J.M., Mirzayans F., Fortin Y., Hudson T.J., Raymond V.,
RA Link B.A., Walter M.A.;
RT "FOXC1 is required for cell viability and resistance to oxidative stress in
RT the eye through the transcriptional regulation of FOXO1A.";
RL Hum. Mol. Genet. 17:490-505(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor that regulates metabolic homeostasis in
CC response to oxidative stress (By similarity). Binds to the consensus
CC sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding
CC element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (By
CC similarity). Main regulator of redox balance and osteoblast numbers and
CC controls bone mass. Orchestrates the endocrine function of the skeleton
CC in regulating glucose metabolism (By similarity).
CC {ECO:0000250|UniProtKB:Q9R1E0}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9R1E0}. Nucleus
CC {ECO:0000250|UniProtKB:Q9R1E0}. Note=Shuttles between the cytoplasm and
CC nucleus. {ECO:0000250|UniProtKB:Q9R1E0}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the developing eye. In 48h embryos,
CC low levels in the developing eye. High levels in the branchial arch
CC region and within the nasal epithelium. branchial arch region and in
CC the developing pancreas. {ECO:0000269|PubMed:17993506}.
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DR EMBL; EF421425; ABO10193.1; -; mRNA.
DR EMBL; AL953846; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC163020; AAI63020.1; -; mRNA.
DR RefSeq; NP_001076326.1; NM_001082857.1.
DR AlphaFoldDB; A3RK75; -.
DR SMR; A3RK75; -.
DR STRING; 7955.ENSDARP00000082331; -.
DR PaxDb; A3RK75; -.
DR Ensembl; ENSDART00000087898; ENSDARP00000082331; ENSDARG00000061549.
DR GeneID; 567969; -.
DR KEGG; dre:567969; -.
DR CTD; 2311; -.
DR ZFIN; ZDB-GENE-080425-3; foxo1b.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000161558; -.
DR HOGENOM; CLU_023456_1_0_1; -.
DR InParanoid; A3RK75; -.
DR OMA; GQYNCPT; -.
DR OrthoDB; 1160384at2759; -.
DR PhylomeDB; A3RK75; -.
DR TreeFam; TF315583; -.
DR PRO; PR:A3RK75; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 10.
DR Bgee; ENSDARG00000061549; Expressed in mature ovarian follicle and 19 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0001945; P:lymph vessel development; IGI:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR032067; FOXO-TAD.
DR InterPro; IPR032068; FOXO_KIX-bd.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR Pfam; PF16676; FOXO-TAD; 1.
DR Pfam; PF16675; FOXO_KIX_bdg; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..629
FT /note="Forkhead box protein O1-B"
FT /id="PRO_0000419247"
FT DNA_BIND 136..230
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 88..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..117
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 629 AA; 68539 MW; E9CE4ED5E7909905 CRC64;
MAEPQQQLVD IDPDFEPLSR PRSCTWPLHR PEFSEQPGNS NTSSPAPSVK PEQGIVDFIN
SLSLLEETED YPDEKPVLLN DFHCQDNCAH PQQQHPQQPN PQLTHPQQVP PLPAPASGSS
PAAAQRKSSS SRRNAWGNMS YADLITKAIE SSPEKRLTLS QIYEWMVKSV PYFKDKGDSN
SSAGWKNSIR HNLSLHSRFV RVQNEGTGKS SWWMLNPEGG KSGKSPRRRA TSMDNNSKFT
KSRGRAAKKK MSLQGGLDGG SNSPGSQYPK WLGSPNSHSN DDFEPWGNFR TRASSDASTL
SGRRSPFLPE EDEAAEVHIG YPGTKLGGPL PSLSEVAGHH GSENMMDNLL ENLNLISPKN
NTQGSQEAQT ALSSPLMQGS PGYPSYTSPN MGPQPQVQQD YRKCLYGQGG VGGLNPISIP
TLSDSKPGGY GPFVGQYNCA PGLLKELLTA DADPRGELMQ SGEGQPVLPS YASQGQMAQG
GKMITHPHLH AHPRSLHQLP SPAMGLNGCA MLPHGHPVRL SSMKPQPHLP HHTHLGRGGG
EAGMPSYTNG NGFHRHGAIA HHHHSHPERL PSDLDDMLID QLDVECDVER VLHDTLMDGD
ALDFNFDPMS SQQSFTHSVK TSTHNWVSG
