FX4L1_HUMAN
ID FX4L1_HUMAN Reviewed; 408 AA.
AC Q9NU39; B3KWN1; B9EGF3;
DT 27-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Forkhead box protein D4-like 1;
DE Short=FOXD4-like 1;
GN Name=FOXD4L1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Heart;
RX PubMed=12421752; DOI=10.1101/gr.338402;
RA Fan Y., Newman T., Linardopoulou E., Trask B.J.;
RT "Gene content and function of the ancestral chromosome fusion site in human
RT chromosome 2q13-2q14.1 and paralogous regions.";
RL Genome Res. 12:1663-1672(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15233989; DOI=10.1016/j.ygeno.2004.03.001;
RA Wong A., Vallender E.J., Heretis K., Ilkin Y., Lahn B.T., Lese Martin C.,
RA Ledbetter D.H.;
RT "Diverse fates of paralogs following segmental duplication of telomeric
RT genes.";
RL Genomics 84:239-247(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9NU39; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-11320806, EBI-11096309;
CC Q9NU39; O95817: BAG3; NbExp=3; IntAct=EBI-11320806, EBI-747185;
CC Q9NU39; Q8N9W6-4: BOLL; NbExp=3; IntAct=EBI-11320806, EBI-11983447;
CC Q9NU39; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-11320806, EBI-11530605;
CC Q9NU39; Q2TAC2-2: CCDC57; NbExp=3; IntAct=EBI-11320806, EBI-10961624;
CC Q9NU39; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11320806, EBI-3867333;
CC Q9NU39; Q15038: DAZAP2; NbExp=3; IntAct=EBI-11320806, EBI-724310;
CC Q9NU39; Q96B26: EXOSC8; NbExp=3; IntAct=EBI-11320806, EBI-371922;
CC Q9NU39; Q96D09: GPRASP2; NbExp=3; IntAct=EBI-11320806, EBI-473189;
CC Q9NU39; O14964: HGS; NbExp=3; IntAct=EBI-11320806, EBI-740220;
CC Q9NU39; Q9NP66: HMG20A; NbExp=3; IntAct=EBI-11320806, EBI-740641;
CC Q9NU39; P61978-2: HNRNPK; NbExp=5; IntAct=EBI-11320806, EBI-7060731;
CC Q9NU39; O76011: KRT34; NbExp=3; IntAct=EBI-11320806, EBI-1047093;
CC Q9NU39; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-11320806, EBI-10176379;
CC Q9NU39; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-11320806, EBI-11962084;
CC Q9NU39; Q9UPY8: MAPRE3; NbExp=3; IntAct=EBI-11320806, EBI-726739;
CC Q9NU39; Q99750: MDFI; NbExp=3; IntAct=EBI-11320806, EBI-724076;
CC Q9NU39; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-11320806, EBI-302345;
CC Q9NU39; Q9NQX0: PRDM6; NbExp=3; IntAct=EBI-11320806, EBI-11320284;
CC Q9NU39; P61289: PSME3; NbExp=3; IntAct=EBI-11320806, EBI-355546;
CC Q9NU39; Q6ZRY4: RBPMS2; NbExp=4; IntAct=EBI-11320806, EBI-11987469;
CC Q9NU39; Q15654: TRIP6; NbExp=3; IntAct=EBI-11320806, EBI-742327;
CC Q9NU39; Q9NZC7-5: WWOX; NbExp=3; IntAct=EBI-11320806, EBI-12040603;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
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DR EMBL; AF452723; AAN64908.1; -; mRNA.
DR EMBL; AY344639; AAQ76877.1; -; mRNA.
DR EMBL; AK125398; BAG54193.1; -; mRNA.
DR EMBL; AL078621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC136428; AAI36429.1; -; mRNA.
DR CCDS; CCDS2117.1; -.
DR RefSeq; NP_036316.1; NM_012184.4.
DR AlphaFoldDB; Q9NU39; -.
DR SMR; Q9NU39; -.
DR BioGRID; 128321; 42.
DR IntAct; Q9NU39; 24.
DR MINT; Q9NU39; -.
DR STRING; 9606.ENSP00000302756; -.
DR iPTMnet; Q9NU39; -.
DR PhosphoSitePlus; Q9NU39; -.
DR BioMuta; FOXD4L1; -.
DR DMDM; 27923782; -.
DR MassIVE; Q9NU39; -.
DR PaxDb; Q9NU39; -.
DR PeptideAtlas; Q9NU39; -.
DR PRIDE; Q9NU39; -.
DR ProteomicsDB; 82653; -.
DR Antibodypedia; 59983; 126 antibodies from 23 providers.
DR DNASU; 200350; -.
DR Ensembl; ENST00000306507.6; ENSP00000302756.5; ENSG00000184492.6.
DR GeneID; 200350; -.
DR KEGG; hsa:200350; -.
DR MANE-Select; ENST00000306507.7; ENSP00000302756.5; NM_012184.5; NP_036316.1.
DR UCSC; uc002tjw.5; human.
DR CTD; 200350; -.
DR DisGeNET; 200350; -.
DR GeneCards; FOXD4L1; -.
DR HGNC; HGNC:18521; FOXD4L1.
DR HPA; ENSG00000184492; Tissue enhanced (testis).
DR MIM; 611084; gene.
DR neXtProt; NX_Q9NU39; -.
DR OpenTargets; ENSG00000184492; -.
DR PharmGKB; PA134928763; -.
DR VEuPathDB; HostDB:ENSG00000184492; -.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000163353; -.
DR HOGENOM; CLU_040357_3_0_1; -.
DR InParanoid; Q9NU39; -.
DR OMA; CAISCAP; -.
DR OrthoDB; 1270467at2759; -.
DR PhylomeDB; Q9NU39; -.
DR TreeFam; TF316127; -.
DR PathwayCommons; Q9NU39; -.
DR SignaLink; Q9NU39; -.
DR BioGRID-ORCS; 200350; 53 hits in 656 CRISPR screens.
DR GenomeRNAi; 200350; -.
DR Pharos; Q9NU39; Tdark.
DR PRO; PR:Q9NU39; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q9NU39; protein.
DR Bgee; ENSG00000184492; Expressed in granulocyte and 48 other tissues.
DR Genevisible; Q9NU39; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..408
FT /note="Forkhead box protein D4-like 1"
FT /id="PRO_0000091824"
FT DNA_BIND 107..201
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 71..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..47
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 29
FT /note="V -> I (in dbSNP:rs9308683)"
FT /id="VAR_059299"
SQ SEQUENCE 408 AA; 43610 MW; 9FD4B5688B0CE758 CRC64;
MNLPRAERPR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEEASQKF LEQSLQPGLQ
VARWGGVALP REHIEGGGPS DPSEFGTEFR APPRSAAASE DARQPAKPPY SYIALITMAI
LQSPHKRLTL SGICAFISGR FPYYRRKFPA WQNSIRHNLS LNDCFVKIPR EPGHPGKGTY
WSLDPASQDM FDNGSFLRRR KRFKRHQLTP GAHLPHPFPL PAAHAALHNP RPGPLLGAPA
LPQPVPGAYP NTAPGRRPYA LLHPHPPRYL LLSAPAYAGA PKKAEGADLA TPGTLPVLQP
SLGPQPWEEG KGLASPPGGG CISFSIESIM QGVRGAGTGA AQSLSPTAWS YCPLLQRPSS
LSDNFAATAA ASGGGLRQRL RSHQGRGAGR APVGRVGAAA VSGGGRGL
