FX4L3_HUMAN
ID FX4L3_HUMAN Reviewed; 417 AA.
AC Q6VB84; Q5JTX9;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Forkhead box protein D4-like 3;
DE Short=FOXD4-like 3;
GN Name=FOXD4L3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15233989; DOI=10.1016/j.ygeno.2004.03.001;
RA Wong A., Vallender E.J., Heretis K., Ilkin Y., Lahn B.T., Lese Martin C.,
RA Ledbetter D.H.;
RT "Diverse fates of paralogs following segmental duplication of telomeric
RT genes.";
RL Genomics 84:239-247(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
CC -!- INTERACTION:
CC Q6VB84; P02654: APOC1; NbExp=3; IntAct=EBI-11961494, EBI-1220105;
CC Q6VB84; Q5H9J7: BEX5; NbExp=3; IntAct=EBI-11961494, EBI-10243741;
CC Q6VB84; Q13137: CALCOCO2; NbExp=3; IntAct=EBI-11961494, EBI-739580;
CC Q6VB84; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-11961494, EBI-3866279;
CC Q6VB84; Q9UHD4: CIDEB; NbExp=3; IntAct=EBI-11961494, EBI-7062247;
CC Q6VB84; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11961494, EBI-3867333;
CC Q6VB84; P61978-2: HNRNPK; NbExp=3; IntAct=EBI-11961494, EBI-7060731;
CC Q6VB84; Q5VWX1: KHDRBS2; NbExp=3; IntAct=EBI-11961494, EBI-742808;
CC Q6VB84; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-11961494, EBI-11959885;
CC Q6VB84; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-11961494, EBI-10176379;
CC Q6VB84; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-11961494, EBI-11962084;
CC Q6VB84; Q99750: MDFI; NbExp=3; IntAct=EBI-11961494, EBI-724076;
CC Q6VB84; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-11961494, EBI-10172526;
CC Q6VB84; Q96CS7: PLEKHB2; NbExp=3; IntAct=EBI-11961494, EBI-373552;
CC Q6VB84; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-11961494, EBI-302345;
CC Q6VB84; Q6ZRY4: RBPMS2; NbExp=3; IntAct=EBI-11961494, EBI-11987469;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
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DR EMBL; AY344642; AAQ76880.1; -; mRNA.
DR EMBL; AL353608; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS43833.1; -.
DR RefSeq; NP_954586.4; NM_199135.4.
DR AlphaFoldDB; Q6VB84; -.
DR SMR; Q6VB84; -.
DR BioGRID; 130365; 16.
DR IntAct; Q6VB84; 16.
DR STRING; 9606.ENSP00000341961; -.
DR BioMuta; FOXD4L3; -.
DR DMDM; 317373356; -.
DR MassIVE; Q6VB84; -.
DR PaxDb; Q6VB84; -.
DR PeptideAtlas; Q6VB84; -.
DR PRIDE; Q6VB84; -.
DR Antibodypedia; 43289; 10 antibodies from 4 providers.
DR DNASU; 286380; -.
DR Ensembl; ENST00000342833.4; ENSP00000341961.2; ENSG00000187559.6.
DR GeneID; 286380; -.
DR KEGG; hsa:286380; -.
DR MANE-Select; ENST00000342833.4; ENSP00000341961.2; NM_199135.4; NP_954586.4.
DR UCSC; uc004agm.2; human.
DR CTD; 286380; -.
DR DisGeNET; 286380; -.
DR GeneCards; FOXD4L3; -.
DR HGNC; HGNC:18523; FOXD4L3.
DR HPA; ENSG00000187559; Tissue enhanced (brain).
DR MIM; 611086; gene.
DR neXtProt; NX_Q6VB84; -.
DR PharmGKB; PA134941846; -.
DR VEuPathDB; HostDB:ENSG00000187559; -.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000163353; -.
DR HOGENOM; CLU_040357_3_1_1; -.
DR InParanoid; Q6VB84; -.
DR OrthoDB; 1270467at2759; -.
DR PhylomeDB; Q6VB84; -.
DR TreeFam; TF316127; -.
DR PathwayCommons; Q6VB84; -.
DR SignaLink; Q6VB84; -.
DR BioGRID-ORCS; 286380; 29 hits in 259 CRISPR screens.
DR GenomeRNAi; 286380; -.
DR Pharos; Q6VB84; Tdark.
DR PRO; PR:Q6VB84; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q6VB84; protein.
DR Bgee; ENSG00000187559; Expressed in right uterine tube and 29 other tissues.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..417
FT /note="Forkhead box protein D4-like 3"
FT /id="PRO_0000301980"
FT DNA_BIND 108..202
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 70..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..47
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 9
FT /note="L -> P (in Ref. 1; AAQ76880)"
FT /evidence="ECO:0000305"
FT CONFLICT 47
FT /note="S -> R (in Ref. 1; AAQ76880)"
FT /evidence="ECO:0000305"
FT CONFLICT 289
FT /note="A -> D (in Ref. 1; AAQ76880)"
FT /evidence="ECO:0000305"
FT CONFLICT 344
FT /note="I -> V (in Ref. 1; AAQ76880)"
FT /evidence="ECO:0000305"
FT CONFLICT 366
FT /note="R -> K (in Ref. 1; AAQ76880)"
FT /evidence="ECO:0000305"
FT CONFLICT 416
FT /note="P -> R (in Ref. 1; AAQ76880)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 417 AA; 45820 MW; 1FD6BD6801493FCE CRC64;
MNLPRAERLR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEAASQQF LEQSLQPGLQ
VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS EDARQPAKPP YSYIALITMA
ILQNPHKRLT LSGICAFISG RFPYYRRKFP AWQNSIRHNL SLNDCFVKIP REPGHPGKGN
YWSLDPASQD MFDNGSFLRR RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PRPGPLLGAP
APPQPVPGAY PNTAPGRRPY ALLHPHPLRY LLLSAPVYAG APKKAEGAAL ATPAPFPCCS
PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRICPRPRG ATATCSSDHQ
ACCIPRPLPL CCKCPPPPLL GQFCSNSSSI RRRTAPTAAL PPRARCWAGT CRPRRPC
