FX4L4_HUMAN
ID FX4L4_HUMAN Reviewed; 416 AA.
AC Q8WXT5; Q5RIB4; Q6VB85;
DT 27-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 2.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Forkhead box protein D4-like 4 {ECO:0000305};
DE Short=FOXD4-like 4 {ECO:0000305};
DE AltName: Full=Forkhead box protein D4-like 2 {ECO:0000312|HGNC:HGNC:23762};
DE AltName: Full=Forkhead box protein D4B {ECO:0000305|PubMed:12234674};
DE AltName: Full=Myeloid factor-gamma {ECO:0000312|EMBL:AAL73342.1};
GN Name=FOXD4L4 {ECO:0000312|HGNC:HGNC:23762};
GN Synonyms=FOXD4B {ECO:0000303|PubMed:12234674},
GN FOXD4L2 {ECO:0000312|HGNC:HGNC:23762};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12234674; DOI=10.1016/s0378-1119(02)00702-3;
RA Freyaldenhoven B.S., Fried C., Wielckens K.;
RT "FOXD4a and FOXD4b, two new winged helix transcription factors, are
RT expressed in human leukemia cell lines.";
RL Gene 294:131-140(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15233989; DOI=10.1016/j.ygeno.2004.03.001;
RA Wong A., Vallender E.J., Heretis K., Ilkin Y., Lahn B.T., Lese Martin C.,
RA Ledbetter D.H.;
RT "Diverse fates of paralogs following segmental duplication of telomeric
RT genes.";
RL Genomics 84:239-247(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=12421752; DOI=10.1101/gr.338402;
RA Fan Y., Newman T., Linardopoulou E., Trask B.J.;
RT "Gene content and function of the ancestral chromosome fusion site in human
RT chromosome 2q13-2q14.1 and paralogous regions.";
RL Genome Res. 12:1663-1672(2002).
CC -!- INTERACTION:
CC Q8WXT5; Q9UPY8: MAPRE3; NbExp=3; IntAct=EBI-12911102, EBI-726739;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
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DR EMBL; AF343005; AAL73342.1; -; Genomic_DNA.
DR EMBL; AY344641; AAQ76879.1; -; mRNA.
DR EMBL; BX284632; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS75845.1; -.
DR RefSeq; NP_954714.2; NM_199244.3.
DR AlphaFoldDB; Q8WXT5; -.
DR SMR; Q8WXT5; -.
DR BioGRID; 131556; 1.
DR IntAct; Q8WXT5; 1.
DR STRING; 9606.ENSP00000366630; -.
DR BioMuta; FOXD4L4; -.
DR DMDM; 158518651; -.
DR MassIVE; Q8WXT5; -.
DR PaxDb; Q8WXT5; -.
DR PeptideAtlas; Q8WXT5; -.
DR PRIDE; Q8WXT5; -.
DR Antibodypedia; 76484; 2 antibodies from 2 providers.
DR DNASU; 349334; -.
DR Ensembl; ENST00000377413.2; ENSP00000366630.1; ENSG00000184659.5.
DR GeneID; 349334; -.
DR KEGG; hsa:349334; -.
DR MANE-Select; ENST00000377413.3; ENSP00000366630.1; NM_199244.3; NP_954714.2.
DR UCSC; uc004afx.2; human.
DR CTD; 349334; -.
DR DisGeNET; 349334; -.
DR GeneCards; FOXD4L4; -.
DR HGNC; HGNC:23762; FOXD4L4.
DR HPA; ENSG00000184659; Tissue enriched (brain).
DR MIM; 611085; gene.
DR neXtProt; NX_Q8WXT5; -.
DR OpenTargets; ENSG00000184659; -.
DR PharmGKB; PA142671752; -.
DR VEuPathDB; HostDB:ENSG00000184659; -.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000163353; -.
DR HOGENOM; CLU_040357_3_1_1; -.
DR InParanoid; Q8WXT5; -.
DR OMA; RPLPPCC; -.
DR OrthoDB; 1270467at2759; -.
DR PhylomeDB; Q8WXT5; -.
DR TreeFam; TF316127; -.
DR PathwayCommons; Q8WXT5; -.
DR SignaLink; Q8WXT5; -.
DR BioGRID-ORCS; 349334; 59 hits in 625 CRISPR screens.
DR GenomeRNAi; 349334; -.
DR Pharos; Q8WXT5; Tdark.
DR PRO; PR:Q8WXT5; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q8WXT5; protein.
DR Bgee; ENSG00000184659; Expressed in right uterine tube and 35 other tissues.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..416
FT /note="Forkhead box protein D4-like 4"
FT /id="PRO_0000091825"
FT DNA_BIND 108..202
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 70..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..47
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 280
FT /note="G -> A (in Ref. 1; AAL73342)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 416 AA; 45892 MW; CA8FCD2D09B5CBC8 CRC64;
MNLPRAERPR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEEARQQF LEQSLQPGLQ
VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS EDARQPAKPP YSYIALITMA
ILQNPHKRLT LSGICAFISG RFPYYRRKFP AWQNSIRHNL SLNDCFVKIP REPGHPGKGN
YWSLDPASQD MFDNGSFLRR RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PHPGPLLGAP
APPQPVPGAY PNTAPGRRPY ALLHPHPLRY LLLSARVYAG APKKAEGADL ATPAPFPCCS
PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRVCPRPRG ATATCSSDHQ
ACCIPKPLPL CCKCPPPLLL GQFCSNSSSI RRTAPTAALP PRARCWAGTC RPRRRC
