ID   FX4L5_HUMAN             Reviewed;         416 AA.
AC   Q5VV16;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Forkhead box protein D4-like 5;
DE            Short=FOXD4-like 5;
GN   Name=FOXD4L5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
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DR   EMBL; AL512605; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS47977.1; -.
DR   RefSeq; NP_001119806.1; NM_001126334.1.
DR   AlphaFoldDB; Q5VV16; -.
DR   SMR; Q5VV16; -.
DR   STRING; 9606.ENSP00000366637; -.
DR   BioMuta; FOXD4L5; -.
DR   DMDM; 74747187; -.
DR   MassIVE; Q5VV16; -.
DR   PaxDb; Q5VV16; -.
DR   PeptideAtlas; Q5VV16; -.
DR   PRIDE; Q5VV16; -.
DR   Antibodypedia; 67846; 24 antibodies from 12 providers.
DR   DNASU; 653427; -.
DR   Ensembl; ENST00000377420.1; ENSP00000366637.1; ENSG00000204779.2.
DR   GeneID; 653427; -.
DR   KEGG; hsa:653427; -.
DR   MANE-Select; ENST00000377420.1; ENSP00000366637.1; NM_001126334.1; NP_001119806.1.
DR   UCSC; uc010moc.3; human.
DR   CTD; 653427; -.
DR   DisGeNET; 653427; -.
DR   GeneCards; FOXD4L5; -.
DR   HGNC; HGNC:18522; FOXD4L5.
DR   HPA; ENSG00000204779; Tissue enhanced (brain).
DR   neXtProt; NX_Q5VV16; -.
DR   OpenTargets; ENSG00000204779; -.
DR   PharmGKB; PA162388804; -.
DR   VEuPathDB; HostDB:ENSG00000204779; -.
DR   eggNOG; KOG2294; Eukaryota.
DR   GeneTree; ENSGT00940000163353; -.
DR   HOGENOM; CLU_040357_3_1_1; -.
DR   InParanoid; Q5VV16; -.
DR   OrthoDB; 1270467at2759; -.
DR   PhylomeDB; Q5VV16; -.
DR   TreeFam; TF316127; -.
DR   PathwayCommons; Q5VV16; -.
DR   BioGRID-ORCS; 653427; 42 hits in 650 CRISPR screens.
DR   GenomeRNAi; 653427; -.
DR   Pharos; Q5VV16; Tdark.
DR   PRO; PR:Q5VV16; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q5VV16; protein.
DR   Bgee; ENSG00000204779; Expressed in cortical plate and 52 other tissues.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..416
FT                   /note="Forkhead box protein D4-like 5"
FT                   /id="PRO_0000301978"
FT   DNA_BIND        108..202
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          1..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          70..105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..25
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..47
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   416 AA;  45780 MW;  24607F2BF39393F9 CRC64;
     MNLPRAERPR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEEARQQF LEQSLQPGLQ
     VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS EDARQPAKPP YSYIALITMA
     ILQNPHKRLT LSGICAFISG RFPYYRRKFP AWQNSIRHNL SLNDCFVKIP REPGHPGKGN
     YWSLDPASQD MFDNGSFLRR RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PHPGPLLGAP
     APPQPVPGAY PNTAPGRCPY ALLHPHPLRY LLLSAPVYAG APKKAEGADL ATPAPFPCCS
     PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRVCPRPRG ATATCSSDHQ
     ACCIPKPLPL CCKCPPPLLL GQFCSNSSSI RRTAPTAALP PRARCWAGTC RPRRRC