FX4L6_HUMAN
ID FX4L6_HUMAN Reviewed; 417 AA.
AC Q3SYB3; B2RPC4; Q4V336;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Forkhead box protein D4-like 6;
DE Short=FOXD4-like 6;
GN Name=FOXD4L6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q3SYB3; P02649: APOE; NbExp=3; IntAct=EBI-6425864, EBI-1222467;
CC Q3SYB3; P78540: ARG2; NbExp=3; IntAct=EBI-6425864, EBI-9056613;
CC Q3SYB3; P54252: ATXN3; NbExp=3; IntAct=EBI-6425864, EBI-946046;
CC Q3SYB3; P99999: CYCS; NbExp=3; IntAct=EBI-6425864, EBI-446479;
CC Q3SYB3; Q9NX09: DDIT4; NbExp=3; IntAct=EBI-6425864, EBI-715104;
CC Q3SYB3; P26378-2: ELAVL4; NbExp=3; IntAct=EBI-6425864, EBI-21603100;
CC Q3SYB3; P42858: HTT; NbExp=6; IntAct=EBI-6425864, EBI-466029;
CC Q3SYB3; P05107: ITGB2; NbExp=3; IntAct=EBI-6425864, EBI-300173;
CC Q3SYB3; P13473-2: LAMP2; NbExp=3; IntAct=EBI-6425864, EBI-21591415;
CC Q3SYB3; Q5T3J3: LRIF1; NbExp=3; IntAct=EBI-6425864, EBI-473196;
CC Q3SYB3; Q99750: MDFI; NbExp=6; IntAct=EBI-6425864, EBI-724076;
CC Q3SYB3; Q92597: NDRG1; NbExp=3; IntAct=EBI-6425864, EBI-716486;
CC Q3SYB3; P00747: PLG; NbExp=3; IntAct=EBI-6425864, EBI-999394;
CC Q3SYB3; P49810: PSEN2; NbExp=3; IntAct=EBI-6425864, EBI-2010251;
CC Q3SYB3; Q6NZ63: STEAP1B; NbExp=3; IntAct=EBI-6425864, EBI-12952093;
CC Q3SYB3; P31948: STIP1; NbExp=3; IntAct=EBI-6425864, EBI-1054052;
CC Q3SYB3; Q92956: TNFRSF14; NbExp=3; IntAct=EBI-6425864, EBI-1056653;
CC Q3SYB3; Q96BH6; NbExp=3; IntAct=EBI-6425864, EBI-25872486;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
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DR EMBL; BX255923; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC103887; AAI03888.1; -; mRNA.
DR EMBL; BC137365; AAI37366.1; -; mRNA.
DR EMBL; BC137366; AAI37367.1; -; mRNA.
DR CCDS; CCDS43826.1; -.
DR RefSeq; NP_001078945.1; NM_001085476.1.
DR AlphaFoldDB; Q3SYB3; -.
DR SMR; Q3SYB3; -.
DR BioGRID; 575756; 49.
DR IntAct; Q3SYB3; 41.
DR STRING; 9606.ENSP00000484875; -.
DR iPTMnet; Q3SYB3; -.
DR PhosphoSitePlus; Q3SYB3; -.
DR BioMuta; FOXD4L6; -.
DR DMDM; 166214939; -.
DR MassIVE; Q3SYB3; -.
DR PaxDb; Q3SYB3; -.
DR PeptideAtlas; Q3SYB3; -.
DR PRIDE; Q3SYB3; -.
DR Antibodypedia; 73303; 20 antibodies from 11 providers.
DR DNASU; 653404; -.
DR Ensembl; ENST00000622588.2; ENSP00000484875.1; ENSG00000273514.2.
DR GeneID; 653404; -.
DR KEGG; hsa:653404; -.
DR MANE-Select; ENST00000622588.2; ENSP00000484875.1; NM_001085476.4; NP_001078945.1.
DR UCSC; uc004afi.3; human.
DR CTD; 653404; -.
DR GeneCards; FOXD4L6; -.
DR HGNC; HGNC:31986; FOXD4L6.
DR HPA; ENSG00000273514; Tissue enhanced (brain).
DR neXtProt; NX_Q3SYB3; -.
DR OpenTargets; ENSG00000273514; -.
DR PharmGKB; PA162388805; -.
DR VEuPathDB; HostDB:ENSG00000273514; -.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000163353; -.
DR HOGENOM; CLU_040357_3_1_1; -.
DR InParanoid; Q3SYB3; -.
DR OMA; TAWSYCH; -.
DR OrthoDB; 1270467at2759; -.
DR PhylomeDB; Q3SYB3; -.
DR TreeFam; TF316127; -.
DR PathwayCommons; Q3SYB3; -.
DR SignaLink; Q3SYB3; -.
DR BioGRID-ORCS; 653404; 196 hits in 594 CRISPR screens.
DR GenomeRNAi; 653404; -.
DR Pharos; Q3SYB3; Tdark.
DR PRO; PR:Q3SYB3; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q3SYB3; protein.
DR Bgee; ENSG00000273514; Expressed in right uterine tube and 31 other tissues.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..417
FT /note="Forkhead box protein D4-like 6"
FT /id="PRO_0000301979"
FT DNA_BIND 108..202
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 70..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..47
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 417 AA; 45787 MW; 0A21FCC4EC1D66CE CRC64;
MNLPRAERLR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEAASQQF LEQSLQPGLQ
VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS EDARQPAKPP YSYIALITMA
ILQNPHKRLT LSGICAFISG RFPYYRRKFP AWQNSIRHNL SLNDCFVKIP REPGHPGKGN
YWSLDPASQD MFDNGSFLRR RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PHPGPLLGAP
APPQPVPGAY PNTAPGRRPY ALLHPHPLRY LLLSAPVYAG APKKAEGAAL ATPAPFPCCS
PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRVCPRPRG ATATCSSDHQ
ACCIPRPLPL CCKCPPPPLL GQFCSNSSSI RRRTAPTAAL PPRARCWAGT CRPRRPC
