ID   FXA1A_XENLA             Reviewed;         429 AA.
AC   Q6LD29;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 2.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Forkhead box protein A1-A;
DE            Short=FoxA1a;
DE   AltName: Full=Fork head domain-related protein 7;
DE            Short=xFD-7;
DE   AltName: Full=Hepatocyte nuclear factor 3-alpha homolog A;
DE            Short=HNF3alpha homolog A;
DE            Short=xHNF3alpha-A;
GN   Name=foxa1-a; Synonyms=hnf-3a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Gastrula {ECO:0000269|PubMed:8735935};
RX   PubMed=8735935;
RA   Lef J., Dege P., Scheucher M., Forsbach-Birk V., Clement J.H., Knoechel W.;
RT   "A fork head related multigene family is transcribed in Xenopus laevis
RT   embryos.";
RL   Int. J. Dev. Biol. 40:245-253(1996).
RN   [2] {ECO:0000305, ECO:0000312|EMBL:AAA85028.1}
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 174-204.
RC   TISSUE=Embryo {ECO:0000269|PubMed:7937122};
RX   PubMed=7937122; DOI=10.1093/nar/22.19.3990;
RA   King M.W., Moore M.J.;
RT   "Novel HOX, POU and FKH genes expressed during bFGF-induced mesodermal
RT   differentiation in Xenopus.";
RL   Nucleic Acids Res. 22:3990-3996(1994).
RN   [3] {ECO:0000305}
RP   REVIEW.
RX   PubMed=15656969; DOI=10.1016/j.gene.2004.09.037;
RA   Pohl B.S., Knoechel W.;
RT   "Of fox and frogs: fox (fork head/winged helix) transcription factors in
RT   Xenopus development.";
RL   Gene 344:21-32(2005).
CC   -!- FUNCTION: Probable transcription factor. {ECO:0000269|PubMed:15656969}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: At neurula stage, expressed in the notochord but
CC       not in the neural floor plate. During tailbud stages, expressed in the
CC       neural floor plate. At stage 35, expressed in the rhombencephalon,
CC       mesencephalon, pharyngeal pouches, foregut and pronephros. At stage 44,
CC       expressed in a region of the gut on the right hand side of the embryo.
CC       Expressed in the adult lung and liver. {ECO:0000269|PubMed:8735935}.
CC   -!- DEVELOPMENTAL STAGE: Expressed zygotically. Expression begins in the
CC       blastula stage. Levels increase throughout gastrulation before
CC       decreasing at the tadpole stage. {ECO:0000269|PubMed:8735935}.
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DR   EMBL; U04873; AAA85028.1; -; mRNA.
DR   RefSeq; XP_018083988.1; XM_018228499.1.
DR   AlphaFoldDB; Q6LD29; -.
DR   SMR; Q6LD29; -.
DR   DNASU; 100125667; -.
DR   GeneID; 100125667; -.
DR   CTD; 100125667; -.
DR   Xenbase; XB-GENE-487356; foxa1.L.
DR   OMA; FKCEKQA; -.
DR   OrthoDB; 1181467at2759; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   Bgee; 100125667; Expressed in stomach and 10 other tissues.
DR   GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; NAS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR013638; Fork-head_N.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018533; Forkhead_box_C.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   Pfam; PF08430; Forkhead_N; 1.
DR   Pfam; PF09354; HNF_C; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..429
FT                   /note="Forkhead box protein A1-A"
FT                   /id="PRO_0000248854"
FT   DNA_BIND        159..253
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          258..341
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        258..277
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..311
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   429 AA;  46688 MW;  A8F675821EC3E7CC CRC64;
     MLGIVKMEGH ETTDWSNYYQ DTQEAYSSVP VSNMTQGLAS MNTYMTMNPM SSSSNMTAAG
     SFNMSYGNSG LGAGLSPSGM SGMGAGAASA MNGMGSGVPS MGTALSPSNM NAMSAQQASM
     NSLSYSSMNP GMSPMAYGSS NMNRARDTKT FRRSYPHAKP PYSYISLITM AIQQAPSKML
     TLSEIYQWIM DLFPYYRQNQ QRWQNSIRHS LSFNDCFVKV ARSPDKPGKG SYWTLHPDSG
     NMFENGCYLR RQKRFKCEKT QGGKGNQDGR KDHSGPSSPL QRVHGKSSQM DSSSSMSNPS
     SSPQALEHNG SNGEMKPQVA AGPSPLSSHQ NHSTHSLAHE SHIHLKGDPH YSFNHPFSIN
     NLMSSSEQQH KLDFKAYEQA LQQYSSYGGG LPGMPLGSPS MSGRGNIEPS ALEPTYYQGV
     YSRPVLNTS