FXA1B_XENLA
ID FXA1B_XENLA Reviewed; 427 AA.
AC P32315; Q5D0A5;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Forkhead box protein A1-B;
DE Short=FoxA1b;
DE AltName: Full=Fork head domain-related protein 7';
DE Short=xFD-7';
DE AltName: Full=Forkhead protein 2;
DE Short=FKH-2;
DE Short=xFKH2;
DE AltName: Full=Hepatocyte nuclear factor 3-alpha homolog B;
DE Short=HNF3alpha homolog B;
DE Short=xHNF3alpha-B;
GN Name=foxa1-b; Synonyms=fkh2;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
RP INDUCTION.
RC TISSUE=Embryonic tail;
RX PubMed=8253274; DOI=10.1006/dbio.1993.1317;
RA Bolce M.E., Hemmati-Brivanlou A., Harland R.M.;
RT "XFKH2, a Xenopus HNF-3 alpha homologue, exhibits both activin-inducible
RT and autonomous phases of expression in early embryos.";
RL Dev. Biol. 160:413-423(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Gastrula;
RX PubMed=8735935;
RA Lef J., Dege P., Scheucher M., Forsbach-Birk V., Clement J.H., Knoechel W.;
RT "A fork head related multigene family is transcribed in Xenopus laevis
RT embryos.";
RL Int. J. Dev. Biol. 40:245-253(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP REVIEW.
RX PubMed=15656969; DOI=10.1016/j.gene.2004.09.037;
RA Pohl B.S., Knoechel W.;
RT "Of fox and frogs: fox (fork head/winged helix) transcription factors in
RT Xenopus development.";
RL Gene 344:21-32(2005).
CC -!- FUNCTION: Probable transcription factor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Present in the vegetal pole and marginal zone but
CC not the animal pole of gastrulae and in equal levels in the dorsal and
CC ventral halves of both gastrulae and neurulae. At neurula stage,
CC expressed in the notochord. During tailbud stages, expressed in the
CC foregut, brain, hypocord, neural floor plate and in two lines of cells
CC just dorsal and ventral to the notochord. Expressed in the adult liver.
CC {ECO:0000269|PubMed:8253274}.
CC -!- DEVELOPMENTAL STAGE: Expression begins at stage 10.25. Levels increase
CC throughout gastrulation before reaching a peak between stages 11.5 and
CC 12. {ECO:0000269|PubMed:8253274}.
CC -!- INDUCTION: By activin. {ECO:0000269|PubMed:8253274}.
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DR EMBL; M93658; AAA17050.1; -; mRNA.
DR EMBL; BC047130; AAH47130.1; -; mRNA.
DR PIR; I51580; I51580.
DR RefSeq; NP_001080063.1; NM_001086594.1.
DR AlphaFoldDB; P32315; -.
DR SMR; P32315; -.
DR DNASU; 379755; -.
DR GeneID; 379755; -.
DR KEGG; xla:379755; -.
DR CTD; 379755; -.
DR Xenbase; XB-GENE-6256649; foxa1.S.
DR OMA; GMYPRPL; -.
DR OrthoDB; 1181467at2759; -.
DR Proteomes; UP000186698; Chromosome 8S.
DR Bgee; 379755; Expressed in stomach and 13 other tissues.
DR GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; NAS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB.
DR GO; GO:0019904; F:protein domain specific binding; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR013638; Fork-head_N.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018533; Forkhead_box_C.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR Pfam; PF08430; Forkhead_N; 1.
DR Pfam; PF09354; HNF_C; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..427
FT /note="Forkhead box protein A1-B"
FT /id="PRO_0000091899"
FT DNA_BIND 157..251
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 256..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..277
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 427 AA; 46572 MW; 2D29A42AF960730C CRC64;
MLGIVKMEGH ETTDWSNYYQ DAQEGYSSVP VSNMPQGLAT MNTYMTMNPM SSGSNITSGS
FNMPYGNSGL GAGLSPSGMS GMGSAGAMNG MGSGVPSMGS ALSPSNMNAI QSAQQASMNS
LSYSSMNSGM SPMGYGATNI NRTRDSKTFR RSYPHAKPPY SYISLITMAI QQAPSKMLTL
SEIYQWIMDL FPYYRQNQQR WQNSIRHSLS FNDCFIKVSR SPDKPGKGSY WTLHPDSGNM
FENGCYLRRQ KRFKCEKTQG GKGNQDGRKD HSGPSSPLHR VHGKSSQMDS SSSMSNPSSS
PQALEHNGSN GEMKPQVAAG PSPLSSHQNH STHSLAHETH IHLKGDPHYS FNHPFSINNL
MSSSEQQHKL DFKAYEQALQ QYSSYGGGLQ GMPLGSPSMT GRGTIEPSAL EPTYYQGVYS
RPVLNTS
