ID   FXA2B_XENLA             Reviewed;         433 AA.
AC   P84961;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Forkhead box protein A2-B;
DE            Short=FoxA2-B;
DE            Short=FoxA2b;
DE   AltName: Full=Fork head domain-related protein 3';
DE            Short=xFD-3';
DE   AltName: Full=Hepatocyte nuclear factor 3-beta homolog B;
DE            Short=HNF-3-beta-B;
DE            Short=HNF3-beta homolog B;
DE            Short=HNF3-beta-B;
DE            Short=xHNF3-beta-B;
GN   Name=foxa2-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Gastrula {ECO:0000269|PubMed:8735935};
RX   PubMed=8735935;
RA   Lef J., Dege P., Scheucher M., Forsbach-Birk V., Clement J.H., Knoechel W.;
RT   "A fork head related multigene family is transcribed in Xenopus laevis
RT   embryos.";
RL   Int. J. Dev. Biol. 40:245-253(1996).
RN   [2] {ECO:0000305}
RP   REVIEW.
RX   PubMed=15656969; DOI=10.1016/j.gene.2004.09.037;
RA   Pohl B.S., Knoechel W.;
RT   "Of fox and frogs: fox (fork head/winged helix) transcription factors in
RT   Xenopus development.";
RL   Gene 344:21-32(2005).
CC   -!- FUNCTION: Acts as a transcriptional activator during early development,
CC       limiting the extent of mesoderm formation in the gastrula. Binds to DNA
CC       via the target sequence 5'-GT[AC]AACA-3', with 5'-GTAAACA-3' being the
CC       preferred binding site (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
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DR   AlphaFoldDB; P84961; -.
DR   SMR; P84961; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; NAS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0001707; P:mesoderm formation; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR013638; Fork-head_N.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018533; Forkhead_box_C.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   Pfam; PF08430; Forkhead_N; 1.
DR   Pfam; PF09354; HNF_C; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..433
FT                   /note="Forkhead box protein A2-B"
FT                   /id="PRO_0000248857"
FT   DNA_BIND        147..241
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          247..337
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          407..433
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        264..296
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        306..330
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   433 AA;  47845 MW;  824133FFD64D53D8 CRC64;
     MLGAVKMEGH EDWSSYYGEP EAYSSVGNMN AGLSMNPMNT YMSMSAMSTS ANMTASSMNM
     SYVNTGMSPS ITGMSPGTGA MPGMGNGVAS MASHLSPSMS PMSAQATSMN ALAPYTNINS
     MSPIYGQSNI NRSRDPKTYR RSYTHAKPPY SYISLITMAI QQSPSKMLTL SEVYQWIMDL
     FPFYRQNQQR WQNSIRHSLS FNDCFLKVPR SPDKPGKGSF WTLHPDSGNM FENGCYLRRQ
     KRFKCDKKPS LREGGGKKLS EGASSVGSVG NSSSERSVGN ESPHSSSSPC QEQKRSLVDM
     KSSHGLSPEH ATSPASQAQH LLSQHHSVLS HEAQSHLKPE HHYSFNHPFS INNLMSSEQQ
     HHHHHHHHNH QHHHKMDLKA YEQVMHYSGY GSPMAGSLAM STVTNKSGLE PSPISSDTSY
     YQGGYSRPIM NSS