FXC1A_DANRE
ID FXC1A_DANRE Reviewed; 476 AA.
AC Q9DE25;
DT 03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Forkhead box C1-A;
GN Name=foxc1a; Synonyms=foxc1.1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DEVELOPMENTAL STAGE.
RX PubMed=11165495; DOI=10.1016/s0925-4773(00)00534-7;
RA Topczewska J.M., Topczewski J., Solnica-Krezel L., Hogan B.L.;
RT "Sequence and expression of zebrafish foxc1a and foxc1b, encoding conserved
RT forkhead/winged helix transcription factors.";
RL Mech. Dev. 100:343-347(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-binding transcriptional factor that plays a role in a
CC broad range of cellular and developmental processes such as eye, bones,
CC cardiovascular, kidney and skin development. Acts either as a
CC transcriptional activator or repressor. Binds to the consensus binding
CC site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon
CC DNA-binding, promotes DNA bending. Required for cell viability and
CC resistance to oxidative stress in the eye. Promotes cell growth
CC inhibition by stopping the cell cycle in the G1 phase through TGFB1-
CC mediated signals. Involved in epithelial-mesenchymal transition (EMT)
CC induction by increasing cell proliferation, migration and invasion.
CC Involved in chemokine-induced endothelial cell migration. Plays a role
CC in epidermal keratinocyte terminal differentiation. Essential
CC developmental transcriptional factor required for mesoderm-derived
CC tissues formation, such as the somites, skin, bone and cartilage. Plays
CC a role in the development and maintenance of mesenchymal niches for
CC haematopoietic stem and progenitor cells (HSPC). Plays a role in
CC corneal transparency by preventing both blood vessel and lymphatic
CC vessel growth during embryonic development in a VEGF-dependent manner.
CC {ECO:0000250|UniProtKB:Q12948, ECO:0000250|UniProtKB:Q61572}.
CC -!- SUBUNIT: Monomer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q61572}.
CC -!- DEVELOPMENTAL STAGE: First detected at the shield stage of gastrulation
CC in the involuting mesendoderm with levels being highest in the paraxial
CC mesoderm and decline laterally to become undetectable in the ventral
CC mesoderm. Expression spreads in the hypoblast towards the animal pole
CC and converges dorsally. At the tail bud stage (9.5 hpf), transcripts
CC are seen in adaxial cells flanking the future notochord and in the
CC presomitic mesoderm (PSM). During early somitogenesis, expression also
CC extends into the future head, in two stripes continuous with the
CC adaxial cells. Expression continues around the developing eye,
CC presomitic mesoderm (PSM), trunk adaxial cells and somites. In late
CC somatogenesis, expression in the presumptive pronephric primodia
CC lateral to the second and third somite. In the early pharyngula stage,
CC expressed in the perioptic mesoderm. Expression continues in the PSM
CC and adaxial cells in the tail. {ECO:0000269|PubMed:11165495}.
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DR EMBL; CU929125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF219949; AAG44241.1; -; Genomic_DNA.
DR EMBL; BC053129; AAH53129.1; -; mRNA.
DR RefSeq; NP_571803.1; NM_131728.3.
DR AlphaFoldDB; Q9DE25; -.
DR SMR; Q9DE25; -.
DR STRING; 7955.ENSDARP00000105372; -.
DR PaxDb; Q9DE25; -.
DR PRIDE; Q9DE25; -.
DR Ensembl; ENSDART00000122732; ENSDARP00000105372; ENSDARG00000091481.
DR GeneID; 100148408; -.
DR KEGG; dre:100148408; -.
DR CTD; 100148408; -.
DR ZFIN; ZDB-GENE-010302-1; foxc1a.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000162303; -.
DR HOGENOM; CLU_035722_3_1_1; -.
DR InParanoid; Q9DE25; -.
DR OMA; HCNLQAM; -.
DR OrthoDB; 1270467at2759; -.
DR PhylomeDB; Q9DE25; -.
DR TreeFam; TF316127; -.
DR PRO; PR:Q9DE25; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 2.
DR Bgee; ENSDARG00000091481; Expressed in presomitic mesoderm and 58 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IDA:ZFIN.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030325; P:adrenal gland development; IGI:ZFIN.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0001568; P:blood vessel development; IGI:ZFIN.
DR GO; GO:0043010; P:camera-type eye development; IGI:ZFIN.
DR GO; GO:0051216; P:cartilage development; IMP:ZFIN.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0061300; P:cerebellum vasculature development; IGI:ZFIN.
DR GO; GO:0061386; P:closure of optic fissure; IMP:ZFIN.
DR GO; GO:0060059; P:embryonic retina morphogenesis in camera-type eye; IGI:ZFIN.
DR GO; GO:0007507; P:heart development; IMP:ZFIN.
DR GO; GO:0008045; P:motor neuron axon guidance; IMP:ZFIN.
DR GO; GO:0048387; P:negative regulation of retinoic acid receptor signaling pathway; IMP:ZFIN.
DR GO; GO:0001755; P:neural crest cell migration; IGI:ZFIN.
DR GO; GO:0033339; P:pectoral fin development; IMP:ZFIN.
DR GO; GO:0072149; P:podocyte cell fate commitment; IGI:ZFIN.
DR GO; GO:0072015; P:podocyte development; IMP:ZFIN.
DR GO; GO:0039021; P:pronephric glomerulus development; IGI:ZFIN.
DR GO; GO:0040036; P:regulation of fibroblast growth factor receptor signaling pathway; IMP:ZFIN.
DR GO; GO:1902366; P:regulation of Notch signaling pathway involved in somitogenesis; IMP:ZFIN.
DR GO; GO:2000583; P:regulation of platelet-derived growth factor receptor-alpha signaling pathway; IGI:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0043114; P:regulation of vascular permeability; IGI:ZFIN.
DR GO; GO:0001756; P:somitogenesis; IMP:ZFIN.
DR GO; GO:0035886; P:vascular associated smooth muscle cell differentiation; IMP:ZFIN.
DR GO; GO:0001944; P:vasculature development; IMP:ZFIN.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR033067; FoxC1.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11829:SF68; PTHR11829:SF68; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..476
FT /note="Forkhead box C1-A"
FT /id="PRO_0000419248"
FT DNA_BIND 74..168
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 169..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 284..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 476 AA; 52173 MW; E79BD7030D20B2D0 CRC64;
MQARYSVSSP NSLGVVPYIS SDQSYYRAAA GGGYTGMPAP MTMYSHAAHD QYPASMARAY
GPYTPQPQPK DMVKPPYSYI ALITMAIQNS PDKKVTLNGI YQFIMERFPF YRDNKQGWQN
SIRHNLSLNE CFVKVPRDDK KPGKGSYWTL DPDSYNMFEN GSFLRRRRRF KKKDAMKDKE
DRGVKEAPSR QAQPQAREQE QSVPGSQPVR IQDIKTENGT STPPQAVSPT LSTVPKIESP
DSSSSMSSGS PHSIPSTRSL SLDSAGEQHH QAPAQGFSVD NIMTSLRGSP HSSGELTPSL
VAPSRTGITP TLSLNYSPNQ SSVYSSPCSQ NSISTTSNAT YHCNMQAMSL YAGGDRSGHL
GTTATTVDET LPDYSITTTT SSLSHGNLSS AQEGHHPHQG RLASWYLNQA GDIGHLGATY
PAQQQNFHSV REMFESQRIG LNNSPVNGNN SCQMSFPPSQ PIYRTSGAFV YDCSKF
