FXC1A_XENLA
ID FXC1A_XENLA Reviewed; 492 AA.
AC Q9PVZ3; B7ZQ99; B7ZQA1; B7ZRK5; Q9YHB2;
DT 19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Forkhead box protein C1-A;
DE Short=FoxC1 {ECO:0000303|PubMed:17705306};
DE AltName: Full=Fork head domain-related protein 11 {ECO:0000303|PubMed:9767159};
DE Short=XFD-11 {ECO:0000303|PubMed:9767159, ECO:0000312|EMBL:CAB44727.1};
GN Name=foxc1-a; Synonyms=foxc1;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAC99469.1}
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC TISSUE=Gastrula {ECO:0000269|PubMed:9767159};
RX PubMed=9767159; DOI=10.1016/s0925-4773(98)00123-3;
RA Koester M., Dillinger K., Knoechel W.;
RT "Expression pattern of the winged helix factor XFD-11 during Xenopus
RT embryogenesis.";
RL Mech. Dev. 76:169-173(1998).
RN [2] {ECO:0000312|EMBL:CAB44727.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Knoechel W.;
RL Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000312|EMBL:CAB44727.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gastrula {ECO:0000312|EMBL:AAI69731.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305}
RP FUNCTION, TISSUE SPECIFICITY, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=17705306; DOI=10.1002/dvdy.21240;
RA Cha J.Y., Birsoy B., Kofron M., Mahoney E., Lang S., Wylie C., Heasman J.;
RT "The role of FoxC1 in early Xenopus development.";
RL Dev. Dyn. 236:2731-2741(2007).
RN [5] {ECO:0000305}
RP REVIEW.
RX PubMed=15656969; DOI=10.1016/j.gene.2004.09.037;
RA Pohl B.S., Knoechel W.;
RT "Of fox and frogs: fox (fork head/winged helix) transcription factors in
RT Xenopus development.";
RL Gene 344:21-32(2005).
CC -!- FUNCTION: DNA-binding transcriptional factor that plays a role in a
CC broad range of cellular and developmental processes such as eye, bones,
CC cardiovascular, kidney and skin development. Acts either as a
CC transcriptional activator or repressor. Binds to the consensus binding
CC site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon
CC DNA-binding, promotes DNA bending. Required for cell viability and
CC resistance to oxidative stress in the eye. Promotes cell growth
CC inhibition by stopping the cell cycle in the G1 phase through TGFB1-
CC mediated signals. Involved in epithelial-mesenchymal transition (EMT)
CC induction by increasing cell proliferation, migration and invasion.
CC Involved in chemokine-induced endothelial cell migration. Plays a role
CC in epidermal keratinocyte terminal differentiation. Essential
CC developmental transcriptional factor required for mesoderm-derived
CC tissues formation, such as the somites, skin, bone and cartilage. Plays
CC a role in the development and maintenance of mesenchymal niches for
CC haematopoietic stem and progenitor cells (HSPC). Plays a role in
CC corneal transparency by preventing both blood vessel and lymphatic
CC vessel growth during embryonic development in a VEGF-dependent manner
CC (By similarity). Plays a role at the gastrula stage for expression of
CC several mesodermal and endodermal genes (PubMed:17705306). At the late
CC neurula stage, regulates expression of adhesion genes to maintain cell
CC adhesion in the mesodermal germ layer (PubMed:17705306).
CC {ECO:0000250|UniProtKB:Q12948, ECO:0000250|UniProtKB:Q61572,
CC ECO:0000269|PubMed:17705306}.
CC -!- SUBUNIT: Monomer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q61572}.
CC -!- TISSUE SPECIFICITY: In gastrulae, expressed in ventral and lateral but
CC not dorsal mesoderm. In neurulae, expressed in the posterior mesoderm
CC except for the dorsal midline, and also at the lateral border of the
CC neural plate and within anterior neuroectoderm. From tailbud stages,
CC expressed in the pronephros, heart, neural crest cells surrounding the
CC eye, in the mandibular, hyoid and branchial arches, and within the
CC tail. {ECO:0000269|PubMed:17705306, ECO:0000269|PubMed:9767159}.
CC -!- DEVELOPMENTAL STAGE: Expressed from late blastula/early gastrula stage
CC throughout embryogenesis. {ECO:0000269|PubMed:9767159}.
CC -!- INDUCTION: By vegt, acting via nodal signaling.
CC {ECO:0000269|PubMed:17705306}.
CC -!- DISRUPTION PHENOTYPE: Embryos gastrulate and neurulate, but at the
CC tailbud stage show stunted growth and loss of cells at the blastopore.
CC Embryos continue to develop but display shortened axes and abnormal gut
CC and heart development by the swimming tadpole stage.
CC {ECO:0000269|PubMed:17705306}.
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DR EMBL; AF116844; AAC99469.1; -; mRNA.
DR EMBL; AJ242675; CAB44727.1; -; mRNA.
DR EMBL; BC169731; AAI69731.1; -; mRNA.
DR EMBL; BC169733; AAI69733.1; -; mRNA.
DR EMBL; BC170199; AAI70199.1; -; mRNA.
DR EMBL; BC170201; AAI70201.1; -; mRNA.
DR RefSeq; NP_001080937.1; NM_001087468.1.
DR RefSeq; NP_001081683.1; NM_001088214.1.
DR AlphaFoldDB; Q9PVZ3; -.
DR SMR; Q9PVZ3; -.
DR PRIDE; Q9PVZ3; -.
DR GeneID; 394280; -.
DR GeneID; 397996; -.
DR KEGG; xla:397996; -.
DR CTD; 394280; -.
DR CTD; 397996; -.
DR Xenbase; XB-GENE-6252135; foxc1.S.
DR OMA; ASWYGDL; -.
DR OrthoDB; 1270467at2759; -.
DR Proteomes; UP000186698; Chromosome 6S.
DR Bgee; 397996; Expressed in internal ear and 10 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR GO; GO:0001568; P:blood vessel development; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IMP:UniProtKB.
DR GO; GO:1990869; P:cellular response to chemokine; ISS:UniProtKB.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; ISS:UniProtKB.
DR GO; GO:0007498; P:mesoderm development; IMP:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0048793; P:pronephros development; IEP:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:UniProtKB.
DR GO; GO:0006351; P:transcription, DNA-templated; IMP:UniProtKB.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR033067; FoxC1.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11829:SF68; PTHR11829:SF68; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..492
FT /note="Forkhead box protein C1-A"
FT /id="PRO_0000390737"
FT DNA_BIND 79..173
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 175..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..280
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 51
FT /note="H -> F (in Ref. 1; AAC99469)"
FT /evidence="ECO:0000305"
FT CONFLICT 63
FT /note="R -> E (in Ref. 1; AAC99469)"
FT /evidence="ECO:0000305"
FT CONFLICT 69
FT /note="T -> A (in Ref. 1; AAC99469)"
FT /evidence="ECO:0000305"
FT CONFLICT 150
FT /note="G -> V (in Ref. 3; AAI69731)"
FT /evidence="ECO:0000305"
FT CONFLICT 241
FT /note="P -> L (in Ref. 1; AAC99469)"
FT /evidence="ECO:0000305"
FT CONFLICT 248
FT /note="L -> F (in Ref. 3; AAI70199)"
FT /evidence="ECO:0000305"
FT CONFLICT 358
FT /note="G -> E (in Ref. 3; AAI69731/AAI69733)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 492 AA; 53674 MW; 66906A5A99A2FD4E CRC64;
MQARYSVSSP NSLGVVPYLS GEQSYYRAAA AAAAAGGGYT GMAAPMSMYS HPAHEQYQAG
MARAYGPYTP QPQPKDMVKP PYSYIALITM AIQNAPDKKI TLNGIYQFIM ERFPFYRDNK
QGWQNSIRHN LSLNECFVKV PRDDKKPGKG SYWTLDPDSY NMFENGSFLR RRRRFKKKDV
SKDATKEDKE RLLKEHHGSQ SAAAQQQRQQ QQSQAQAEQD SNSQPVRIQD IKTENGTSSP
PQSMSPALSA VPKIESPDSS SSMSSGSPHS IPSNRSMSLE AAESHHPHHQ QHSQGFSVDN
IMTSLRGSPQ GSAELPSPLI SSSRTGIAPS LSLSYSPGQG SIYSSPCSQG TSSGGGAGTY
HCNMQAMSLY SGDRSGHLTP ANTPAATTVE ETLPDYSIST TSAQSHGNQE HPHQGRLPSW
YLNQTGELGH LAGATYPGQQ QNFHSVREMF ESQRLALNSS PVNGNSSCQM SFPPSQSLYR
TSGAFVYDCS KF
