FXC1B_DANRE
ID FXC1B_DANRE Reviewed; 433 AA.
AC Q9DE24;
DT 03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Forkhead box C1-B;
GN Name=foxc1b; Synonyms=foxc1.2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DEVELOPMENTAL STAGE.
RX PubMed=11165495; DOI=10.1016/s0925-4773(00)00534-7;
RA Topczewska J.M., Topczewski J., Solnica-Krezel L., Hogan B.L.;
RT "Sequence and expression of zebrafish foxc1a and foxc1b, encoding conserved
RT forkhead/winged helix transcription factors.";
RL Mech. Dev. 100:343-347(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-binding transcriptional factor that plays a role in a
CC broad range of cellular and developmental processes such as eye, bones,
CC cardiovascular, kidney and skin development. Acts either as a
CC transcriptional activator or repressor. Binds to the consensus binding
CC site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon
CC DNA-binding, promotes DNA bending. Required for cell viability and
CC resistance to oxidative stress in the eye. Promotes cell growth
CC inhibition by stopping the cell cycle in the G1 phase through TGFB1-
CC mediated signals. Involved in epithelial-mesenchymal transition (EMT)
CC induction by increasing cell proliferation, migration and invasion.
CC Involved in chemokine-induced endothelial cell migration. Plays a role
CC in epidermal keratinocyte terminal differentiation. Essential
CC developmental transcriptional factor required for mesoderm-derived
CC tissues formation, such as the somites, skin, bone and cartilage. Plays
CC a role in the development and maintenance of mesenchymal niches for
CC haematopoietic stem and progenitor cells (HSPC). Plays a role in
CC corneal transparency by preventing both blood vessel and lymphatic
CC vessel growth during embryonic development in a VEGF-dependent manner.
CC {ECO:0000250|UniProtKB:Q12948, ECO:0000250|UniProtKB:Q61572}.
CC -!- SUBUNIT: Monomer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q61572}.
CC -!- DEVELOPMENTAL STAGE: First detected at the shield stage of gastrulation
CC in the involuting mesendoderm with levels being highest in the paraxial
CC mesoderm and decline laterally to become undetectable in the ventral
CC mesoderm. Expression spreads in the hypoblast towards the animal pole
CC and converges dorsally. At the tail bud stage (9.5 hpf), transcripts
CC are seen in adaxial cells flanking the future notochord and in the
CC presomitic mesoderm (PSM). During early somitogenesis, expression also
CC extends into the future head, in two stripes continuous with the
CC adaxial cells. Expression continues under the hindbrain as far as the
CC midbrain/hindbrain boundary, in the presomitic mesoderm (PSM), trunk
CC adaxial cells and somites. Expression still found, in the early
CC pharyngula stage. in the PSM and adaxial cells in the tail and, at 33
CC to 70 hpf, strong expression in the pharyngeal arches and saggital
CC sections. {ECO:0000269|PubMed:11165495}.
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DR EMBL; AF219950; AAG44242.1; -; Genomic_DNA.
DR EMBL; BX510653; CAI12069.1; -; Genomic_DNA.
DR EMBL; BC046028; AAH46028.1; -; mRNA.
DR RefSeq; NP_571804.1; NM_131729.2.
DR AlphaFoldDB; Q9DE24; -.
DR SMR; Q9DE24; -.
DR STRING; 7955.ENSDARP00000072219; -.
DR PaxDb; Q9DE24; -.
DR Ensembl; ENSDART00000077753; ENSDARP00000072219; ENSDARG00000055398.
DR GeneID; 79375; -.
DR KEGG; dre:79375; -.
DR CTD; 79375; -.
DR ZFIN; ZDB-GENE-010302-2; foxc1b.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000162303; -.
DR HOGENOM; CLU_035722_3_1_1; -.
DR InParanoid; Q9DE24; -.
DR OMA; LAPWYLN; -.
DR OrthoDB; 1270467at2759; -.
DR PhylomeDB; Q9DE24; -.
DR TreeFam; TF316127; -.
DR PRO; PR:Q9DE24; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 20.
DR Bgee; ENSDARG00000055398; Expressed in zone of skin and 39 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0001568; P:blood vessel development; IGI:ZFIN.
DR GO; GO:0043010; P:camera-type eye development; IGI:ZFIN.
DR GO; GO:0051216; P:cartilage development; IMP:ZFIN.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0061300; P:cerebellum vasculature development; IGI:ZFIN.
DR GO; GO:0060059; P:embryonic retina morphogenesis in camera-type eye; IGI:ZFIN.
DR GO; GO:0001755; P:neural crest cell migration; IGI:ZFIN.
DR GO; GO:2000583; P:regulation of platelet-derived growth factor receptor-alpha signaling pathway; IGI:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0043114; P:regulation of vascular permeability; IGI:ZFIN.
DR GO; GO:0001944; P:vasculature development; IMP:ZFIN.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR033067; FoxC1.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11829:SF68; PTHR11829:SF68; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..433
FT /note="Forkhead box C1-B"
FT /id="PRO_0000419249"
FT DNA_BIND 74..168
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 174..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 318..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..190
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..355
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 433 AA; 47918 MW; 8941A9DBB9B837B9 CRC64;
MQARYPVSSQ SPLGVVPYIP GDQGFYRTAT GGGYTGMPAP MSMYSHATHE QYPGGMARAY
GPYAPAQQPK DMVKPPYSYI ALITMAIQNS SDKKITLNGI YQFIMERFPF YRDNKQGWQN
SIRHNLSLNE CFVKVPRDDK KPGKGSYWTL DPDSYNMFEN GSFLRRRRRF KKKDVLREKE
DRDRQGKDNP GQACEQDAQQ PVKLRDIKTE NGACTPPHDS TPPLSTVPKT ESPDRSGGSA
CSGSPQSQTP QQAFSMDTIM TGLRGSPQHA AELPASRAAL PGSVSLTYSP TPQPAHYSPP
CGQPATYHCN MQATSLYTGD RGHGDDTLPE YTNTTNASSI SHPHQSSSQE SQHLQQNRLA
PWYLNQSGEL GHLSASYPGQ QQNFHAVREM FETQRIALNS SPVTGSNSCQ MAFPSSQPLY
RASGAFVYDC SKF
