FXC2A_XENLA
ID FXC2A_XENLA Reviewed; 465 AA.
AC Q9PVY9; Q2T9G0;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Forkhead box protein C2-A;
DE Short=FoxC2-A;
DE Short=FoxC2a;
DE AltName: Full=Fork head domain-related protein 4;
DE Short=FD-4;
DE Short=xFD-4;
DE Short=xFD4 A;
DE AltName: Full=Forkhead protein 7;
DE Short=FKH-7;
DE Short=xFKH7;
GN Name=foxc2-a; Synonyms=fkh7;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:CAB54143.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=11180837; DOI=10.1007/s004270050319;
RA Koester M., Dillinger K., Knoechel W.;
RT "Activin A signaling directly activates Xenopus winged helix factors XFD-
RT 4/4', the orthologues to mammalian MFH-1.";
RL Dev. Genes Evol. 210:320-324(2000).
RN [2] {ECO:0000312|EMBL:AAI11545.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neurula {ECO:0000312|EMBL:AAI11545.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-216, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RA Scheucher M., Dege P., Lef J., Hille S., Knoechel W.;
RT "Transcription patterns of four different fork head/HNF-3 related genes
RT (XFD-4, 6, 9 and 10) in Xenopus laevis embryos.";
RL Roux's Arch. Dev. Biol. 204:203-211(1995).
RN [4] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 63-173.
RX PubMed=1358174; DOI=10.1016/0925-4773(92)90007-7;
RA Knoechel S., Lef J., Clement J.H., Klocke B., Hille S., Koester M.,
RA Knoechel W.;
RT "Activin A induced expression of a fork head related gene in posterior
RT chordamesoderm (notochord) of Xenopus laevis embryos.";
RL Mech. Dev. 38:157-165(1992).
RN [5] {ECO:0000305}
RP IDENTIFICATION.
RX PubMed=7937122; DOI=10.1093/nar/22.19.3990;
RA King M.W., Moore M.J.;
RT "Novel HOX, POU and FKH genes expressed during bFGF-induced mesodermal
RT differentiation in Xenopus.";
RL Nucleic Acids Res. 22:3990-3996(1994).
RN [6] {ECO:0000305}
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=8735935;
RA Lef J., Dege P., Scheucher M., Forsbach-Birk V., Clement J.H., Knoechel W.;
RT "A fork head related multigene family is transcribed in Xenopus laevis
RT embryos.";
RL Int. J. Dev. Biol. 40:245-253(1996).
RN [7] {ECO:0000305}
RP PUTATIVE FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=11291856;
RA El-Hodiri H., Bhatia-Dey N., Kenyon K., Ault K., Dirksen M.-L., Jamrich M.;
RT "Fox (forkhead) genes are involved in the dorso-ventral patterning of the
RT Xenopus mesoderm.";
RL Int. J. Dev. Biol. 45:265-271(2001).
RN [8] {ECO:0000305}
RP REVIEW.
RX PubMed=15656969; DOI=10.1016/j.gene.2004.09.037;
RA Pohl B.S., Knoechel W.;
RT "Of fox and frogs: fox (fork head/winged helix) transcription factors in
RT Xenopus development.";
RL Gene 344:21-32(2005).
CC -!- FUNCTION: Transcriptional activator (By similarity). May be involved in
CC the dorso-ventral patterning of the mesoderm.
CC {ECO:0000250|UniProtKB:Q61850, ECO:0000269|PubMed:11291856}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
CC -!- TISSUE SPECIFICITY: After the mid-blastula transition, expressed in the
CC dorsolateral mesoderm but not within the dorsal blastopore lip. During
CC gastrulation and neurulation, expressed within the dorsal mesoderm and
CC the lateral border of the neural plate but not within the dorsal
CC midline. In neurula stage embryos, expressed throughout the entire
CC somite-forming mesoderm, at the border between mesoderm and ectoderm
CC but not within the notochord, neuroectoderm or lateral plate mesoderm.
CC From stage 25 to stage 32, expressed in branchial arches, head
CC mesenchyme, neural crest cells, tail tip and in two segmented lines of
CC cells bordering the somites. Tail tip expression persists throughout
CC later development. From stage 32, expressed in the ventral abdominal
CC muscle and around the spinal cord. Only weakly expressed in the
CC pronephric tubules. At hatching, expressed within the heart, foregut,
CC hindbrain and pharyngeal pouches. {ECO:0000269|PubMed:11180837,
CC ECO:0000269|PubMed:11291856, ECO:0000269|PubMed:8735935,
CC ECO:0000269|Ref.3}.
CC -!- DEVELOPMENTAL STAGE: Expression begins after the mid-blastula
CC transition (stage 8-8.5) becoming most abundant during gastrulation,
CC then decreasing as development progresses. Expression remains at a very
CC low level during the tailbud and tadpole stages.
CC {ECO:0000269|PubMed:11180837, ECO:0000269|PubMed:8735935,
CC ECO:0000269|Ref.3}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI11545.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AJ249224; CAB54143.1; -; Genomic_DNA.
DR EMBL; BC111544; AAI11545.1; ALT_SEQ; mRNA.
DR PIR; E56556; E56556.
DR RefSeq; NP_001089960.2; NM_001096491.2.
DR AlphaFoldDB; Q9PVY9; -.
DR SMR; Q9PVY9; -.
DR DNASU; 735030; -.
DR GeneID; 735030; -.
DR KEGG; xla:735030; -.
DR CTD; 735030; -.
DR Xenbase; XB-GENE-865122; foxc2.L.
DR OMA; REMFTSH; -.
DR OrthoDB; 1270467at2759; -.
DR Proteomes; UP000186698; Chromosome 4L.
DR Bgee; 735030; Expressed in internal ear and 9 other tissues.
DR GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; NAS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:1990841; F:promoter-specific chromatin binding; ISS:UniProtKB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0007498; P:mesoderm development; IEP:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..465
FT /note="Forkhead box protein C2-A"
FT /id="PRO_0000250438"
FT DNA_BIND 72..166
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 174..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 79
FT /note="A -> G (in Ref. 3; no nucleotide entry and 4; no
FT nucleotide entry)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 465 AA; 51614 MW; 15DFE9AD881E7245 CRC64;
MMQARYSVAD PNALGVVPYL SEQNYYRAAG TYGSMATPMS VYPTHEQYTQ GMGRSYGPYH
HHQPTAPKDL VKPPYSYIAL ITMAIQNAPD KKITLNGIYQ FIMDRFPFYR ENKQGWQNSI
RHNLSLNECF VKVPRDDKKP GKGSYWSLDP DSYNMFENGS FLRRRRRFKR KDVCREKEDR
LLKDQGKAQG PISSLELPKH EKKIVIKSES PELPVITKVE NLSPDGGSAM QDSPRSVAST
PSVSTDNSIP DQHPASNGFS VENIMTLRTS PHGDLSPVPQ VPCRTGMVPS LPINYTAQTQ
SSVYSQACTQ SMDTSGSYQC TMRAMSLYAG DRPSHMCAPS SLEEATSEHH NGTSSPLTSM
SLGSGQESVL TSSHHQQTAT GGQTAAPWYL NPGADIGHLS GHNFGSQQQT FPNVREMFNS
HRLGIESSAL SEHQVSGNTN CQIPYRSAPS IYRHSSPYAY DCTKY
