ID   FXC2B_XENLA             Reviewed;         461 AA.
AC   Q9PVY8; B7ZRJ9;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JAN-2010, sequence version 2.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Forkhead box protein C2-B;
DE            Short=FoxC2-B;
DE            Short=FoxC2b;
DE   AltName: Full=Fork head domain-related protein 4';
DE            Short=FD-4';
DE            Short=xFD-4';
DE            Short=xFD4 B;
GN   Name=foxc2-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:CAB54144.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP   AND INDUCTION.
RX   PubMed=11180837; DOI=10.1007/s004270050319;
RA   Koester M., Dillinger K., Knoechel W.;
RT   "Activin A signaling directly activates Xenopus winged helix factors XFD-
RT   4/4', the orthologues to mammalian MFH-1.";
RL   Dev. Genes Evol. 210:320-324(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000305}
RP   IDENTIFICATION.
RX   PubMed=7937122; DOI=10.1093/nar/22.19.3990;
RA   King M.W., Moore M.J.;
RT   "Novel HOX, POU and FKH genes expressed during bFGF-induced mesodermal
RT   differentiation in Xenopus.";
RL   Nucleic Acids Res. 22:3990-3996(1994).
RN   [4] {ECO:0000305}
RP   REVIEW.
RX   PubMed=15656969; DOI=10.1016/j.gene.2004.09.037;
RA   Pohl B.S., Knoechel W.;
RT   "Of fox and frogs: fox (fork head/winged helix) transcription factors in
RT   Xenopus development.";
RL   Gene 344:21-32(2005).
CC   -!- FUNCTION: Transcriptional activator. May be involved in the dorso-
CC       ventral patterning of the mesoderm (By similarity).
CC       {ECO:0000250|UniProtKB:Q61850, ECO:0000250|UniProtKB:Q9PVY9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: After the mid-blastula transition, expressed in the
CC       dorsolateral mesoderm but not within the dorsal blastopore lip. During
CC       gastrulation and neurulation, expressed within the dorsal mesoderm and
CC       the lateral border of the neural plate but not within the dorsal
CC       midline. In neurula stage embryos, expressed at the border between
CC       mesoderm and ectoderm but not within the notochord and neuroectoderm.
CC       From stage 25 to stage 32, expressed in branchial arches, head
CC       mesenchmye, neural crest cells, tail tip and in two segmented lines of
CC       cells bordering the somites. Tail tip expression persists throughout
CC       later development. From stage 32, expressed in the ventral abdominal
CC       muscle and around the spinal cord. Only weakly expressed in the
CC       pronephric tubules. {ECO:0000269|PubMed:11180837}.
CC   -!- DEVELOPMENTAL STAGE: Expression begins after the mid-blastula
CC       transition (stage 8-8.5) becoming most abundant during neurulation,
CC       then gradually decreasing as development progresses. Expression remains
CC       in hatching larvae. {ECO:0000269|PubMed:11180837}.
CC   -!- INDUCTION: By activin and by smad2. {ECO:0000269|PubMed:11180837}.
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DR   EMBL; AJ249225; CAB54144.1; -; mRNA.
DR   EMBL; BC170193; AAI70193.1; -; mRNA.
DR   EMBL; BC170195; AAI70195.1; -; mRNA.
DR   RefSeq; NP_001083920.1; NM_001090451.1.
DR   AlphaFoldDB; Q9PVY8; -.
DR   SMR; Q9PVY8; -.
DR   GeneID; 399191; -.
DR   KEGG; xla:399191; -.
DR   CTD; 399191; -.
DR   Xenbase; XB-GENE-6254394; foxc2.S.
DR   OrthoDB; 1270467at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 399191; Expressed in internal ear and 7 other tissues.
DR   GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; NAS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:1990841; F:promoter-specific chromatin binding; ISS:UniProtKB.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0007498; P:mesoderm development; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..461
FT                   /note="Forkhead box protein C2-B"
FT                   /id="PRO_0000250439"
FT   DNA_BIND        72..166
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          166..194
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          221..258
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          341..380
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        224..258
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        264
FT                   /note="I -> S (in Ref. 1; CAB54144)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        267
FT                   /note="L -> R (in Ref. 1; CAB54144)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   461 AA;  51145 MW;  E0C894D8477F244D CRC64;
     MMQARYSVAD PNALGVVPYL SEQNYYRAAG TYGSMATPMS VYPAHEQYTP AMARSYGPYH
     HHQQAAPKDL VKPPYSYIAL ITMAIQNAPD KKITLNGIYQ FIMDRFPFYR ENKQGWQNSI
     RHNLSLNECF VKVPRDDKKP GKGSYWSLDP DSYNMFENGS FLRRRRRFKK KDASREKEDR
     LLKDQGKVQG PVPSLELPKH EKKIIIKSES PELPVITKVE NLSPGGGSAM QDSPRSVAST
     PSVSTDSSIP EQHPASNGFS VDNIMTLRTS PHGDLSPVPA IPCRTAMVSS LPINYTAHTQ
     SSVYSQACTQ SMDTSGSFQC SMRAMSLYTG DRPSHMCAPS TLEEATSEHH NGTSSPLNSM
     SQESVLTSSH HQQTATGGQT AAPWYLNPGA DIGHLSGHNF GSQQQTFPNV REMFNSHRLG
     IESSALSEHQ VSGNTNCQIP YRSAPSIYRH SSPYAYDCTK Y