FXD5A_XENLA
ID FXD5A_XENLA Reviewed; 352 AA.
AC Q9PRJ8;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Forkhead box protein D5-A;
DE Short=FoxD5-A;
DE Short=FoxD5a;
DE AltName: Full=Fork head domain-related protein 12;
DE Short=xFD-12;
DE AltName: Full=XlFoxD5a;
GN Name=foxd5-a; Synonyms=foxd5a {ECO:0000312|EMBL:CAH64537.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:CAB44728.1}
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC TISSUE=Gastrula {ECO:0000269|PubMed:10559492};
RX PubMed=10559492; DOI=10.1016/s0925-4773(99)00195-1;
RA Soelter M., Koester M., Hollemann T., Brey A., Pieler T., Knoechel W.;
RT "Characterization of a subfamily of related winged helix genes, XFD-
RT 12/12'/12'' (XFLIP), during Xenopus embryogenesis.";
RL Mech. Dev. 89:161-165(1999).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAD47811.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, DEVELOPMENTAL STAGE, AND INDUCTION.
RC TISSUE=Embryo {ECO:0000269|PubMed:11401404};
RX PubMed=11401404; DOI=10.1006/dbio.2001.0191;
RA Sullivan S.A., Akers L., Moody S.A.;
RT "foxD5a, a Xenopus winged helix gene, maintains an immature neural ectoderm
RT via transcriptional repression that is dependent on the C-terminal
RT domain.";
RL Dev. Biol. 232:439-457(2001).
RN [3] {ECO:0000312|EMBL:CAH64537.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15555577; DOI=10.1016/j.bbrc.2004.10.177;
RA Schoen C., Koester M., Knoechel W.;
RT "A downstream enhancer is essential for Xenopus FoxD5 transcription.";
RL Biochem. Biophys. Res. Commun. 325:1360-1366(2004).
RN [4] {ECO:0000305}
RP REVIEW.
RX PubMed=15656969; DOI=10.1016/j.gene.2004.09.037;
RA Pohl B.S., Knoechel W.;
RT "Of fox and frogs: fox (fork head/winged helix) transcription factors in
RT Xenopus development.";
RL Gene 344:21-32(2005).
CC -!- FUNCTION: Transcriptional repressor with a role in dorsal axis
CC formation and neural plate expansion; maintains an undifferentiated
CC neural ectoderm after neural induction. {ECO:0000269|PubMed:11401404}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089,
CC ECO:0000269|PubMed:11401404}.
CC -!- TISSUE SPECIFICITY: Maternal expression is localized to the animal
CC hemisphere of the cleavage embryo. In pre-gastrula embryos, zygotic
CC expression begins in the presumptive neural ectoderm. During
CC gastrulation, expression is confined to the superficial layer of cells
CC in the dorsal blastopore lip (Spemann organizer). Also expressed at a
CC lower level in the paraxial mesoderm but not in the notochord.
CC Expression is subsequently lost until after neural tube closure when
CC expression re-initiates in the tailtip within the entire neural tube
CC and paraxial mesoderm, but not in the notochord.
CC {ECO:0000269|PubMed:10559492, ECO:0000269|PubMed:11401404}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically. First
CC expressed at stage II of oogenesis. Maternal expression levels are low
CC and become further reduced after fertilization. Zygotic expression
CC begins at the mid-blastula transition and peaks during the
CC gastrula/neurula stages. A lower level of expression is then maintained
CC during tailbud and later stages. {ECO:0000269|PubMed:10559492,
CC ECO:0000269|PubMed:11401404}.
CC -!- INDUCTION: Strongly by siamois, moderately by cer1 and weakly by wnt8
CC and nog. {ECO:0000269|PubMed:11401404}.
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DR EMBL; AJ242676; CAB44728.1; -; mRNA.
DR EMBL; AF162782; AAD47811.1; -; mRNA.
DR EMBL; AJ850135; CAH64537.1; -; Genomic_DNA.
DR RefSeq; NP_001081998.1; NM_001088529.2.
DR AlphaFoldDB; Q9PRJ8; -.
DR SMR; Q9PRJ8; -.
DR GeneID; 398170; -.
DR KEGG; xla:398170; -.
DR CTD; 398170; -.
DR Xenbase; XB-GENE-865254; foxd4l1.1.S.
DR OrthoDB; 1270467at2759; -.
DR Proteomes; UP000186698; Chromosome 1S.
DR Bgee; 398170; Expressed in gastrula and 2 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; NAS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0001840; P:neural plate development; IMP:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Neurogenesis; Nucleus;
KW Reference proteome; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..352
FT /note="Forkhead box protein D5-A"
FT /id="PRO_0000259615"
FT DNA_BIND 97..191
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 54..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 352 AA; 39719 MW; 24F3DA0EA2A6891C CRC64;
MSFSQESGAH HHPQDYAGLS DEEDEIDILG EDDPCSLKSH FYLQPTHSVM GDSEMLSPSK
LSCTESESDS SGESEGGTSK DSSTTPTGSK AKRTLVKPPY SYIALITMAI LQSPHKKLTL
SGICDFISSK FPYYKDKFPA WQNSIRHNLS LNDCFIKIPR EPGNPGKGNY WTLDPASEDM
FDNGSFLRRR KRFKRHQQEF FKDGLMMYNS LPYYRPYSAI QPQPVLQQTS LTCMAIPETL
PMSTHLAPYP DIKRKVSYPA QGVHRGFKAQ DADNHPNNSQ SKCSFSIENI MRKPKEPEPN
IQSFNSHWNY NHVFQRPSSC LLPAVLNLST GPLLANTQGA RQYNLIQFPG CY
