ID   FXD5C_XENLA             Reviewed;         342 AA.
AC   Q9PT67;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Forkhead box protein D5-C;
DE            Short=FoxD5-C;
DE            Short=FoxD5c;
DE   AltName: Full=Fork head domain-related protein 12'';
DE            Short=xFD-12'';
DE   AltName: Full=XlFoxD5c;
GN   Name=foxd5-c; Synonyms=foxd5c {ECO:0000303|PubMed:15656969};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:CAB44730.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Gastrula {ECO:0000269|PubMed:10559492};
RX   PubMed=10559492; DOI=10.1016/s0925-4773(99)00195-1;
RA   Soelter M., Koester M., Hollemann T., Brey A., Pieler T., Knoechel W.;
RT   "Characterization of a subfamily of related winged helix genes, XFD-
RT   12/12'/12'' (XFLIP), during Xenopus embryogenesis.";
RL   Mech. Dev. 89:161-165(1999).
RN   [2] {ECO:0000305}
RP   REVIEW.
RX   PubMed=15656969; DOI=10.1016/j.gene.2004.09.037;
RA   Pohl B.S., Knoechel W.;
RT   "Of fox and frogs: fox (fork head/winged helix) transcription factors in
RT   Xenopus development.";
RL   Gene 344:21-32(2005).
CC   -!- FUNCTION: Transcriptional repressor. {ECO:0000250|UniProtKB:Q9PRJ8}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: At the onset of gastrulation, expressed in the
CC       superficial layer of cells in the dorsal blastopore lip (Spemann
CC       organizer). In the open neural plate, expressed in a row of cells
CC       destined to become the floor plate of the neural tube. After neural
CC       tube closure, only detected in the tailtip and a small area located at
CC       the midbrain/hindbrain boundary. {ECO:0000269|PubMed:10559492}.
CC   -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC       Maternal expression levels are low and become further reduced after
CC       fertilization. Zygotic expression begins at the mid-blastula transition
CC       and peaks during the gastrula/neurula stages. A lower level of
CC       expression is then maintained during tailbud and later stages.
CC       {ECO:0000269|PubMed:10559492}.
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DR   EMBL; AJ242678; CAB44730.1; -; mRNA.
DR   RefSeq; NP_001079097.1; NM_001085628.1.
DR   AlphaFoldDB; Q9PT67; -.
DR   SMR; Q9PT67; -.
DR   GeneID; 373630; -.
DR   KEGG; xla:373630; -.
DR   CTD; 373630; -.
DR   Xenbase; XB-GENE-6252884; foxd4l1.2.L.
DR   OMA; IENIMGE; -.
DR   OrthoDB; 1270467at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 373630; Expressed in gastrula and 1 other tissue.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; NAS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..342
FT                   /note="Forkhead box protein D5-C"
FT                   /id="PRO_0000259617"
FT   DNA_BIND        97..191
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          1..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   342 AA;  38498 MW;  665D66F09F27F4FD CRC64;
     MNLSQDSSAH HQSQDYAGVS DDEDEIDILG EDDPCSPRSH IYQQPTDSDM GDRGVLSPSK
     LSCNESASHS SGERERGTSK HSLDTTTNGK VKRALVKPPY SYIALITIAI MQSPHKKLTL
     SGICDFISSK FPYYKDKFPA WQNSIRHNLS LNDCFIKIPR EPGNPGKGNY WTLDPASKDM
     FDNGSFLRRR KRFKRQHQEL FKDGLVMYNP LHYCTPNSAL QAQQIPMTCL AIPENFAMPN
     HLVPYPDINI TVPCPDQGVH RVLTAQDVDN HPSNSHSKCS FSIENIMGET KEPEKHLTSF
     NQNWNYNHLL QSSRLCLLPS GSHLANAHHS AQCNLIKFPG CY