ID   FXDC2_MACFA             Reviewed;         333 AA.
AC   Q9GKT2; Q9BGQ4;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Fatty acid hydroxylase domain-containing protein 2;
GN   Name=FAXDC2; ORFNames=QccE-20373, QflA-14437;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex, and Frontal cortex;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K.,
RA   Suzuki Y., Sugano S., Hashimoto K.;
RT   "Isolation of full-length cDNA clones from macaque brain cDNA libraries.";
RL   Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Promotes megakaryocyte differentiation by enhancing ERK
CC       phosphorylation and up-regulating RUNX1 expression.
CC       {ECO:0000250|UniProtKB:Q96IV6}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96IV6}.
CC       Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the sterol desaturase family. {ECO:0000305}.
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DR   EMBL; AB052147; BAB19002.1; -; mRNA.
DR   EMBL; AB056418; BAB33076.1; -; mRNA.
DR   RefSeq; NP_001274618.1; NM_001287689.1.
DR   RefSeq; XP_005558419.1; XM_005558362.2.
DR   RefSeq; XP_005558420.1; XM_005558363.2.
DR   AlphaFoldDB; Q9GKT2; -.
DR   STRING; 9541.XP_005558418.1; -.
DR   GeneID; 102134726; -.
DR   KEGG; mcf:102134726; -.
DR   CTD; 10826; -.
DR   eggNOG; KOG0873; Eukaryota.
DR   OrthoDB; 1321777at2759; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:InterPro.
DR   GO; GO:0045654; P:positive regulation of megakaryocyte differentiation; ISS:UniProtKB.
DR   GO; GO:0001934; P:positive regulation of protein phosphorylation; ISS:UniProtKB.
DR   InterPro; IPR006694; Fatty_acid_hydroxylase.
DR   Pfam; PF04116; FA_hydroxylase; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..333
FT                   /note="Fatty acid hydroxylase domain-containing protein 2"
FT                   /id="PRO_0000249849"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        215..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          176..299
FT                   /note="Fatty acid hydroxylase"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        301
FT                   /note="T -> I (in Ref. 1; BAB33076)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        311
FT                   /note="K -> R (in Ref. 1; BAB33076)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   333 AA;  38885 MW;  B99755D843312A06 CRC64;
     MKGEAGHMLH NEKSKQEGYI WGSMRRTAFI LGSGLLSFVA FWNSVTWHLQ RFWGASGYFW
     QAQWERLLTT FEGKEWILFF IGAIQVPCLF FWSFNGLLLV VDTTGKPNFI SRYRIQVGKN
     EPVDPVKLRQ SIRTVLFNQC MVSFPMVVFL YPFLKWWGDP CRRELPTFHW FLLELAIFTL
     IEEVLFYYSH RLLHHPTFYK KIHKKHHEWT APIGVISLYA HPIEHVVSNM LPAIVGPLVM
     GSHLSSITMW FSLALIITTI SHCGYHLPFL PSPEFHDYHH LKFNQCYGVL GVLDHLHGTD
     TMFKQTKAYE KHVLLLGFTP LSESIPDSPK RMQ