ID   FXF1A_XENLA             Reviewed;         373 AA.
AC   Q9W706;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Forkhead box protein F1-A;
DE            Short=FoxF1-A;
DE            Short=FoxF1a;
DE   AltName: Full=Fork head domain-related protein 13;
DE            Short=xFD-13;
GN   Name=foxf1-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:CAB44732.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Tail bud {ECO:0000269|PubMed:10525191};
RX   PubMed=10525191; DOI=10.1016/s0925-4773(99)00159-8;
RA   Koester M., Dillinger K., Knoechel W.;
RT   "Genomic structure and embryonic expression of the Xenopus winged helix
RT   factors XFD-13/13'.";
RL   Mech. Dev. 88:89-93(1999).
RN   [2] {ECO:0000305}
RP   REVIEW.
RX   PubMed=15656969; DOI=10.1016/j.gene.2004.09.037;
RA   Pohl B.S., Knoechel W.;
RT   "Of fox and frogs: fox (fork head/winged helix) transcription factors in
RT   Xenopus development.";
RL   Gene 344:21-32(2005).
CC   -!- FUNCTION: Probable transcription factor. Required for smooth muscle
CC       (visceral mesoderm) differentiation during gut development. Also
CC       required for normal proliferation of the lateral plate mesoderm. Acts
CC       as a downstream mediator of bmp4-signaling (By similarity).
CC       {ECO:0000250|UniProtKB:Q9W707, ECO:0000269|PubMed:15656969}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: During neurulation and tailbud stages, expressed in
CC       the lateral plate mesoderm and in the neural crest-derived structures
CC       of the head and branchial arches. During tailbud stages, expressed in
CC       the pronephros and pronephros ducts and in cells that migrate from the
CC       dorsolateral plate to the ventral region of the embryo (with the
CC       notable exception of the heart). These cells may represent
CC       hematopoietic or endothelial progenitor cells.
CC       {ECO:0000269|PubMed:10525191}.
CC   -!- DEVELOPMENTAL STAGE: Expression begins at late gastrula/early neurula
CC       stage and increases towards the end of embryogenesis.
CC       {ECO:0000269|PubMed:10525191}.
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DR   EMBL; AJ242680; CAB44732.1; -; mRNA.
DR   RefSeq; NP_001084262.1; NM_001090793.1.
DR   AlphaFoldDB; Q9W706; -.
DR   SMR; Q9W706; -.
DR   GeneID; 399398; -.
DR   KEGG; xla:399398; -.
DR   CTD; 399398; -.
DR   Xenbase; XB-GENE-865226; foxf1.L.
DR   OMA; SGVMEPH; -.
DR   OrthoDB; 1120805at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 399398; Expressed in lung and 9 other tissues.
DR   GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0030509; P:BMP signaling pathway; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0048566; P:embryonic digestive tract development; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR   GO; GO:0048745; P:smooth muscle tissue development; ISS:UniProtKB.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..373
FT                   /note="Forkhead box protein F1-A"
FT                   /id="PRO_0000259400"
FT   DNA_BIND        54..148
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          1..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..24
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   373 AA;  40357 MW;  040EEE7BAD63A896 CRC64;
     MTAEIQQPPS QPPAQSSPMS AATDKHGGQP SAMESASCAT KTKKTNAGIR RPEKPPYSYI
     ALIVMAIQSS PTKRLTLSEI YQFLQSRFPF FRGSYQGWKN SVRHNLSLNE CFIKLPKGLG
     RPGKGHYWTI DPASEFMFEE GSFRRRPRGF RRKCQALKPM YSMMNGLGFN HIPESYSFQG
     ASGTISCPPN SLSLDSGIGM MNGHLPSNVD GMGLSGHPVS HLAANGAHSY MGSCTGSSGG
     DYSHHDSGSP LLGGGGVMEP HSVYSSPASA WAPSASTPYI KQQPLSPCNT AANPLSSSLS
     SHSLDQSYLH QNSHNTASEL QGIPRYHSQS PSMNDRKEFV FSFNAMASSS MHSGSGSYYH
     QQVGYQDIKP CVM