ID   FXF1B_XENLA             Reviewed;         372 AA.
AC   Q9W707; Q32NL9;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Forkhead box protein F1-B;
DE            Short=FoxF1-B;
DE            Short=FoxF1b;
DE   AltName: Full=Fork head domain-related protein 13';
DE            Short=xFD-13';
GN   Name=foxf1-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:CAB44731.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, AND
RP   DEVELOPMENTAL STAGE.
RC   TISSUE=Tail bud {ECO:0000269|PubMed:10525191};
RX   PubMed=10525191; DOI=10.1016/s0925-4773(99)00159-8;
RA   Koester M., Dillinger K., Knoechel W.;
RT   "Genomic structure and embryonic expression of the Xenopus winged helix
RT   factors XFD-13/13'.";
RL   Mech. Dev. 88:89-93(1999).
RN   [2] {ECO:0000312|EMBL:AAI08568.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula {ECO:0000312|EMBL:AAI08568.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000305}
RP   TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND INDUCTION.
RX   PubMed=11291856;
RA   El-Hodiri H., Bhatia-Dey N., Kenyon K., Ault K., Dirksen M.-L., Jamrich M.;
RT   "Fox (forkhead) genes are involved in the dorso-ventral patterning of the
RT   Xenopus mesoderm.";
RL   Int. J. Dev. Biol. 45:265-271(2001).
RN   [4] {ECO:0000305}
RP   FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RX   PubMed=15229177; DOI=10.1242/dev.01234;
RA   Tseng H.-T., Shah R., Jamrich M.;
RT   "Function and regulation of FoxF1 during Xenopus gut development.";
RL   Development 131:3637-3647(2004).
RN   [5] {ECO:0000305}
RP   REVIEW.
RX   PubMed=15656969; DOI=10.1016/j.gene.2004.09.037;
RA   Pohl B.S., Knoechel W.;
RT   "Of fox and frogs: fox (fork head/winged helix) transcription factors in
RT   Xenopus development.";
RL   Gene 344:21-32(2005).
CC   -!- FUNCTION: Probable transcription factor. Required for smooth muscle
CC       (visceral mesoderm) differentiation during gut development. Also
CC       required for normal proliferation of the lateral plate mesoderm. Acts
CC       as a downstream mediator of bmp4-signaling.
CC       {ECO:0000269|PubMed:15229177, ECO:0000269|PubMed:15656969}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: At the late gastrula stage, expressed in the
CC       presumptive ventrolateral mesoderm. During neurulation and tailbud
CC       stages, expressed in the lateral plate mesoderm and in the neural
CC       crest-derived structures of the head and branchial arches. During
CC       tailbud stages, expressed in the pronephros and pronephros ducts and in
CC       cells that migrate from the dorsolateral plate to the ventral region of
CC       the embryo (with the notable exception of the heart). These cells may
CC       represent hematopoietic or endothelial progenitor cells.
CC       {ECO:0000269|PubMed:10525191, ECO:0000269|PubMed:11291856,
CC       ECO:0000269|PubMed:15229177}.
CC   -!- DEVELOPMENTAL STAGE: Expression begins at late gastrula/early neurula
CC       stage and increases towards the end of embryogenesis.
CC       {ECO:0000269|PubMed:10525191, ECO:0000269|PubMed:11291856}.
CC   -!- INDUCTION: By bmp4, probably acting indirectly via t/bra. Also induced
CC       to a lower extent by fgf and activin. {ECO:0000269|PubMed:11291856,
CC       ECO:0000269|PubMed:15229177}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI08568.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ242679; CAB44731.1; -; Genomic_DNA.
DR   EMBL; BC108567; AAI08568.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001090140.1; NM_001096671.1.
DR   AlphaFoldDB; Q9W707; -.
DR   SMR; Q9W707; -.
DR   DNASU; 735218; -.
DR   GeneID; 735218; -.
DR   KEGG; xla:735218; -.
DR   CTD; 735218; -.
DR   Xenbase; XB-GENE-6254084; foxf1.S.
DR   OMA; MGICTES; -.
DR   OrthoDB; 1120805at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 735218; Expressed in lung and 7 other tissues.
DR   GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0030509; P:BMP signaling pathway; IMP:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0048566; P:embryonic digestive tract development; IMP:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR   GO; GO:0048745; P:smooth muscle tissue development; IMP:UniProtKB.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..372
FT                   /note="Forkhead box protein F1-B"
FT                   /id="PRO_0000259401"
FT   DNA_BIND        54..148
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          1..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..24
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   372 AA;  40290 MW;  388089A07F1C25CC CRC64;
     MTAEIQQPPS QPPAQSSPMS AATDKHGGQP SAMESASCAT KTKKTNAGIR RPEKPPYSYI
     ALIVMAIQSS PTKRLTLSEI YQFLQSRFPF FRGSYQGWKN SVRHNLSLNE CFIKLPKGLG
     RPGKGHYWTI DPASEFMFEE GSFRRRPRGF RRKCQALKPM YSMMNGLGFN HIPDTYSFQG
     ASGTISCPPN SLSLDSGIGM MNGHLPSNVD GMGLSGHSVS HLTANGAHSY MGSCTGASGG
     DYSHHDSGSP LLGGGVMDPH SVYSSPASAW APSASTPYIK QQPLSPCNTA ANPLSSSLSS
     HSLDQSYLHQ NSHNTASELQ GIPRYHSQSP SMNDRKEFVF SFNAMASSSM HSGSGSYYHQ
     QVGYQDIKPC VM