FXI1C_XENLA
ID FXI1C_XENLA Reviewed; 381 AA.
AC Q8JIT5;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Forkhead box protein I1c;
DE Short=FoxI1c;
DE Short=xFoxI1c;
DE AltName: Full=Fork head domain-related protein 10;
DE Short=xFD-10;
GN Name=foxi1c {ECO:0000303|PubMed:12204271, ECO:0000303|PubMed:15656969};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:CAD31849.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=12204271; DOI=10.1016/s0925-4773(02)00184-3;
RA Pohl B.S., Knoechel S., Dillinger K., Knoechel W.;
RT "Sequence and expression of FoxB2 (XFD-5) and FoxI1c (XFD-10) in Xenopus
RT embryogenesis.";
RL Mech. Dev. 117:283-287(2002).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 76-273, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RA Scheucher M., Dege P., Lef J., Hille S., Knoechel W.;
RT "Transcription patterns of four different fork head/HNF-3 related genes
RT (XFD-4, 6, 9 and 10) in Xenopus laevis embryos.";
RL Roux's Arch. Dev. Biol. 204:203-211(1995).
RN [3] {ECO:0000305}
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=8735935;
RA Lef J., Dege P., Scheucher M., Forsbach-Birk V., Clement J.H., Knoechel W.;
RT "A fork head related multigene family is transcribed in Xenopus laevis
RT embryos.";
RL Int. J. Dev. Biol. 40:245-253(1996).
RN [4] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=15223346; DOI=10.1016/j.ydbio.2004.04.013;
RA Schlosser G., Ahrens K.;
RT "Molecular anatomy of placode development in Xenopus laevis.";
RL Dev. Biol. 271:439-466(2004).
RN [5] {ECO:0000305}
RP REVIEW.
RX PubMed=15656969; DOI=10.1016/j.gene.2004.09.037;
RA Pohl B.S., Knoechel W.;
RT "Of fox and frogs: fox (fork head/winged helix) transcription factors in
RT Xenopus development.";
RL Gene 344:21-32(2005).
CC -!- FUNCTION: Probable transcription factor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Detected at stage 14 (late gastrula) in a
CC horseshoe-shaped ring surrounding the neural plate. In neurula stage
CC embryos, expressed in the neuroectoderm and pre-somitogenic mesoderm
CC with expression in the outer rim of the neural crest and neural plate
CC at stage 17. Subsequently expressed at different levels in a subset of
CC placodes, excluding the otic and posterior lateral line placodes. In
CC tailbud stages, expressed in neural crest cells that originate from the
CC rhombencephalon and migrate to the ventral part to form the hyoid and
CC anterior branchial arches. At stage 41 (tadpole), expressed in a region
CC of the body wall lateral and posterior to the gills, which is probably
CC the primordium of the ventral trunk. {ECO:0000269|PubMed:12204271,
CC ECO:0000269|PubMed:15223346, ECO:0000269|PubMed:8735935,
CC ECO:0000269|Ref.2}.
CC -!- DEVELOPMENTAL STAGE: Expression doesn't begin until the late gastrula
CC stage. Levels then accumulate continuously, peaking during tailbud
CC stages (stage 31) before decreasing during the tadpole stages.
CC {ECO:0000269|PubMed:12204271, ECO:0000269|PubMed:8735935,
CC ECO:0000269|Ref.2}.
CC -!- CAUTION: The foxi1-C gene is not pseudo-allelic to foxi1-A and foxi1-B.
CC {ECO:0000305}.
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DR EMBL; AJ487620; CAD31849.1; -; Genomic_DNA.
DR RefSeq; NP_001091120.1; NM_001097651.1.
DR AlphaFoldDB; Q8JIT5; -.
DR SMR; Q8JIT5; -.
DR MaxQB; Q8JIT5; -.
DR GeneID; 446212; -.
DR KEGG; xla:446212; -.
DR CTD; 446212; -.
DR Xenbase; XB-GENE-5996119; foxi4.1.L.
DR OMA; FHNFSMV; -.
DR OrthoDB; 1270467at2759; -.
DR Proteomes; UP000186698; Chromosome 1L.
DR Bgee; 446212; Expressed in neurula embryo and 2 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..381
FT /note="Forkhead box protein I1c"
FT /id="PRO_0000258004"
FT DNA_BIND 129..223
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..230
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 381 AA; 42123 MW; 80809EAF005F1130 CRC64;
MNSIHLPSNQ RTSASSLHQH HPKGAQEASE MAVYCDNFSM YHQQNLHSSQ RAPNYGIGDY
APPTNPYLWL GGPGVSNSSS YLHGNNPTSF MSPSYGSQRQ FLSNSSSFCG TDLSWLSVAS
QEELLKVVRP PYSYSALIAM AIQNAPEKKL TLSQIYQYVA ENFPFYKRSK AGWQNSIRHN
LSLNDCFKKV PRDEDDPGKG NYWTLDPNCE KMFDNGNFRR KRKRRSDSSS AEAVTVKGEE
GRPALGGKGG ESPSMLTPSS PELEAASDDR KSTSPSGITS SPCLNNFFSS MTSLDTTSVN
RQMSLGLVNE LSQRNITGLG SFTSGSIAEP SVDLQDNSLH LNRPSYYSTF SSTHQNNQFN
SHFYNTFSVN SLIYAREGSE V
