ID   FXI1C_XENTR             Reviewed;         358 AA.
AC   Q28D67;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Forkhead box protein I1c;
DE            Short=FoxI1c;
GN   Name=foxi1c {ECO:0000250|UniProtKB:Q8JIT5}; ORFNames=TGas113f01.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:CAJ83910.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula {ECO:0000312|EMBL:CAJ83910.1};
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable transcription factor.
CC       {ECO:0000250|UniProtKB:Q8JIT5}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
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DR   EMBL; CR855676; CAJ83910.1; -; mRNA.
DR   RefSeq; NP_001016787.1; NM_001016787.2.
DR   AlphaFoldDB; Q28D67; -.
DR   SMR; Q28D67; -.
DR   GeneID; 549541; -.
DR   KEGG; xtr:549541; -.
DR   CTD; 549541; -.
DR   Xenbase; XB-GENE-5996107; foxi4.1.
DR   eggNOG; KOG2294; Eukaryota.
DR   InParanoid; Q28D67; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..358
FT                   /note="Forkhead box protein I1c"
FT                   /id="PRO_0000258005"
FT   DNA_BIND        106..200
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          191..255
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        191..207
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   358 AA;  39479 MW;  0DD7C14706E0BA18 CRC64;
     MNSIHLPSHQ RTSAPGLHQH RPKGAQEASE MAVYCDNFSM YHQQNLHSSQ RAPNYGIGDY
     APPTNPYLWL GGPGVSNSPS NSSSFCGTDL SWLSVASQEE LLKVVRPPYS YSALIAMAIQ
     NAPEKKLTLS QIYQYVADNF PFYKRSKAGW QNSIRHNLSL NDCFKKVPRD EDDPGKGNYW
     TLDPNCEKMF DNGNFRRKRK RRSDSSSAEA VTVKGEEGRP ALGGKGGESP LMLTPSSPEL
     EAASDGRKST SPSGITSSPC LNNFFSSMTS LDTTSVNRQM SMGLVNELSQ RNITGLGSFT
     SGSVAEPSVD LQDNSLHLNR PSYYSTLSST HQNNQFNSHF YNTFSVNSLI YAREGSEV