FXI1E_XENLA
ID FXI1E_XENLA Reviewed; 373 AA.
AC Q7ZYQ0;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Forkhead box protein I1-ema;
DE Short=FoxI1-ema;
DE AltName: Full=Ectodermally-expressed mesendoderm antagonist;
DE Short=Xema;
DE AltName: Full=FoxI3;
GN Name=foxi1e;
GN Synonyms=ema, foxi1 {ECO:0000312|EMBL:AAH42303.1},
GN foxi3 {ECO:0000303|PubMed:14579370};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAY45746.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=15901660; DOI=10.1242/dev.01865;
RA Suri C., Haremaki T., Weinstein D.C.;
RT "Xema, a foxi-class gene expressed in the gastrula stage Xenopus ectoderm,
RT is required for the suppression of mesendoderm.";
RL Development 132:2733-2742(2005).
RN [2] {ECO:0000312|EMBL:AAH42303.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000312|EMBL:AAH42303.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305}
RP IDENTIFICATION.
RX PubMed=14579370; DOI=10.1002/dvdy.10373;
RA Solomon K.S., Logsdon J.M. Jr., Fritz A.;
RT "Expression and phylogenetic analyses of three zebrafish FoxI class
RT genes.";
RL Dev. Dyn. 228:301-307(2003).
RN [4]
RP FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=17229765; DOI=10.1242/dev.02768;
RA Mir A., Kofron M., Zorn A.M., Bajzer M., Haque M., Heasman J., Wylie C.C.;
RT "FoxI1e activates ectoderm formation and controls cell position in the
RT Xenopus blastula.";
RL Development 134:779-788(2007).
RN [5]
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=18234171; DOI=10.1016/j.ydbio.2007.12.022;
RA Mir A., Kofron M., Heasman J., Mogle M., Lang S., Birsoy B., Wylie C.;
RT "Long- and short-range signals control the dynamic expression of an animal
RT hemisphere-specific gene in Xenopus.";
RL Dev. Biol. 315:161-172(2008).
CC -!- FUNCTION: Transcriptional activator. Activates ectoderm, in addition to
CC inhibiting mesoderm and endoderm formation; required at the blastula
CC stage for normal formation of both the central nervous system and
CC epidermis, the two early derivatives of the ectoderm. In addition, also
CC required to maintain the regional identity of the animal cells of the
CC blastula, the cells that are precursors of ectodermal structures. Also
CC plays a role in differential adhesion, which limits cell mixing as
CC primary germ layers become specified. {ECO:0000269|PubMed:15901660,
CC ECO:0000269|PubMed:17229765}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed dynamically in a dorsal to ventral wave
CC in the animal cap ectoderm in late blastula and gastrula stages.
CC Expression is present in the cap in a salt and pepper arrangement which
CC is maintained throughout early development. Expressed in lower levels
CC in the mesoderm. At later stages, expression is lost from the
CC developing nervous system, but epidermal expression persists through
CC tailbud stages. {ECO:0000269|PubMed:15901660,
CC ECO:0000269|PubMed:17229765, ECO:0000269|PubMed:18234171}.
CC -!- DEVELOPMENTAL STAGE: Expression begins at stage 8.5, after the mid-
CC blastula transition. Expression is highest at early gastrula stages and
CC is maintained throughout neurula, tailbud and early tadpole stages.
CC {ECO:0000269|PubMed:15901660}.
CC -!- INDUCTION: Inhibited by nodal signaling downstream of vegt, and by
CC notch signaling downstream of dvr1/vg1. Neurula stage, but not early
CC stage, expression is regulated by canonical wnt signaling.
CC {ECO:0000269|PubMed:17229765, ECO:0000269|PubMed:18234171}.
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DR EMBL; DQ026065; AAY45746.1; -; mRNA.
DR EMBL; BC042303; AAH42303.1; -; mRNA.
DR RefSeq; NP_001080367.1; NM_001086898.1.
DR AlphaFoldDB; Q7ZYQ0; -.
DR SMR; Q7ZYQ0; -.
DR MaxQB; Q7ZYQ0; -.
DR DNASU; 380059; -.
DR GeneID; 380059; -.
DR KEGG; xla:380059; -.
DR CTD; 380059; -.
DR Xenbase; XB-GENE-494129; foxi1.L.
DR OMA; TGIIYHR; -.
DR OrthoDB; 1270467at2759; -.
DR Proteomes; UP000186698; Chromosome 3L.
DR Bgee; 380059; Expressed in kidney and 10 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0042664; P:negative regulation of endodermal cell fate specification; IMP:UniProtKB.
DR GO; GO:0048335; P:negative regulation of mesodermal cell fate determination; IMP:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR033065; Foxi1.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11829:SF180; PTHR11829:SF180; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..373
FT /note="Forkhead box protein I1-ema"
FT /id="PRO_0000274810"
FT DNA_BIND 123..217
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 208..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 373 AA; 41347 MW; 923C06E70E821E83 CRC64;
MSAFDPQAHS PPRCGPQFPS IGQEPPEMNI YCESFLHPQT MPSPQRPSNF ETGDYSTTAN
PYLWLNGPSI TPPPYLPGSN SSHFMPQAYG MQRQLLPNMH GLGSSELGWL PIPSQEELMK
LVRPPYSYSA LIAMAIHGAP DKRLTLSQIY QYVADNFPFY NKSKAGWQNS IRHNLSLNDC
FKKVPRDEDD PGKGNYWTLD PNCEKMFDNG NFRRKRKRKS DVSPNGQLSS DKPEGSPLSE
SPTNGEHQDM LGNSSPGTDD SPEKRSPPPS ITPCLNNFLS SMTAYVNSAT PISRSVPLGL
SNETSDKMGQ NMVGFNSYTP LSNMPSHGGS DWSSTVSSNP FGYSSSVFNQ FTPHFYNSMS
TNNTLYNREG TEV
