ID   FXI1E_XENTR             Reviewed;         373 AA.
AC   Q6P8A3;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Forkhead box protein I1-ema;
DE            Short=FoxI1-ema;
DE   AltName: Full=Ectodermally-expressed mesendoderm antagonist;
DE   AltName: Full=FoxI3;
GN   Name=foxi1e; Synonyms=ema, foxi1, foxi3 {ECO:0000303|PubMed:14579370};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAH61326.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula {ECO:0000312|EMBL:AAH61326.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   IDENTIFICATION.
RX   PubMed=14579370; DOI=10.1002/dvdy.10373;
RA   Solomon K.S., Logsdon J.M. Jr., Fritz A.;
RT   "Expression and phylogenetic analyses of three zebrafish FoxI class
RT   genes.";
RL   Dev. Dyn. 228:301-307(2003).
CC   -!- FUNCTION: Transcriptional activator. Activates ectoderm, in addition to
CC       inhibiting mesoderm and endoderm formation; required at the blastula
CC       stage for normal formation of both the central nervous system and
CC       epidermis, the two early derivatives of the ectoderm. In addition, also
CC       required to maintain the regional identity of the animal cells of the
CC       blastula, the cells that are precursors of ectodermal structures. Also
CC       plays a role in differential adhesion, which limits cell mixing as
CC       primary germ layers become specified (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
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DR   EMBL; BC061326; AAH61326.1; -; mRNA.
DR   RefSeq; NP_988949.1; NM_203618.1.
DR   AlphaFoldDB; Q6P8A3; -.
DR   SMR; Q6P8A3; -.
DR   STRING; 8364.ENSXETP00000005340; -.
DR   PaxDb; Q6P8A3; -.
DR   Ensembl; ENSXETT00000005340; ENSXETP00000005340; ENSXETG00000025404.
DR   GeneID; 394546; -.
DR   KEGG; xtr:394546; -.
DR   CTD; 2299; -.
DR   Xenbase; XB-GENE-494125; foxi1.
DR   eggNOG; KOG2294; Eukaryota.
DR   HOGENOM; CLU_046860_1_0_1; -.
DR   InParanoid; Q6P8A3; -.
DR   OMA; KREPFIR; -.
DR   OrthoDB; 1270467at2759; -.
DR   PhylomeDB; Q6P8A3; -.
DR   TreeFam; TF316127; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000025404; Expressed in mesonephros and 7 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0042664; P:negative regulation of endodermal cell fate specification; ISS:UniProtKB.
DR   GO; GO:0048335; P:negative regulation of mesodermal cell fate determination; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR033065; Foxi1.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11829:SF180; PTHR11829:SF180; 1.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..373
FT                   /note="Forkhead box protein I1-ema"
FT                   /id="PRO_0000274811"
FT   DNA_BIND        123..217
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          208..274
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        223..237
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        254..274
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   373 AA;  41369 MW;  9452FB1B4AD6B70F CRC64;
     MSAFDPQAHS PPRCGPQFPS IGQEPPEMNI YCDSIFHPQT MPSPQRPSNF ETADYSTTAN
     PYLWLNGPSI TPPPYLPGSN TSHFMPQSYG MQRQLLPNMH GLGGSDLGWL PIPSQEELMK
     LVRPPYSYSA LIAMAIHGAP DKRLTLSQIY QYVADNFPFY NKSKAGWQNS IRHNLSLNDC
     FKKVPRDEDD PGKGNYWTLD PNCEKMFDNG NFRRKRKRKS DVSPNGQISS DKPEGSPLNE
     SPKNGEHHDM LGNSSPGTDD SSEKRSPPPS ITPCLNNFLS SMTAYVNSAN PVSRSVPLGL
     TNEPSDRMGQ NMVGLNSYTP LSNMPSHGGS DWSSTISSSP FGYSSSVFNQ FTPHFYNTIN
     ANNTLYNREG TEV