ID   FXI2A_XENLA             Reviewed;         369 AA.
AC   Q5NDM2;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Forkhead box protein I2-A;
DE   AltName: Full=XlFoxI2-A;
GN   Name=foxi2-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:CAI30462.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=15744668; DOI=10.1387/ijdb.051977bp;
RA   Pohl B.S., Roessner A., Knoechel W.;
RT   "The Fox gene family in Xenopus laevis: FoxI2, FoxM1 and FoxP1 in early
RT   development.";
RL   Int. J. Dev. Biol. 49:53-58(2005).
CC   -!- FUNCTION: Possible transcriptional activator. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Localized to the animal hemisphere of early
CC       cleavage stage embryos. Zygotic expression is restricted to the dorsal
CC       part of the epibranchial placodes of the head within a region located
CC       near the tip of the first, second and third visceral pouch.
CC       {ECO:0000269|PubMed:15744668}.
CC   -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC       Maternal levels decrease rapidly during the early cleavage stages.
CC       Zygotic expression begins at neurulation.
CC       {ECO:0000269|PubMed:15744668}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ868112; CAI30462.1; -; mRNA.
DR   RefSeq; NP_001089009.1; NM_001095540.1.
DR   AlphaFoldDB; Q5NDM2; -.
DR   SMR; Q5NDM2; -.
DR   GeneID; 496395; -.
DR   KEGG; xla:496395; -.
DR   CTD; 496395; -.
DR   Xenbase; XB-GENE-982127; foxi2.S.
DR   OrthoDB; 1270467at2759; -.
DR   Proteomes; UP000186698; Chromosome 7S.
DR   Bgee; 496395; Expressed in blastula and 7 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..369
FT                   /note="Forkhead box protein I2-A"
FT                   /id="PRO_0000247728"
FT   DNA_BIND        124..218
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          215..252
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        215..241
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   369 AA;  40648 MW;  4043531365F65F7B CRC64;
     MNTFGQQPTN PHAQDLLDMA MYCDHFSLYH QQQNQQLPQR PAAPPATGYG LNEYSSPPSS
     PYLWLNGPAI NSSPYLNGGS GSPYFPAGYG GGQRQFLPPS SGFGVADFPW LSIPNQADLL
     KMVRPPYSYS SLIAMAIQNT PDKKLTLSQI YNYVAENFPF YKKSKAGWQN SIRHNLSLND
     CFKKVARDDH DPGKGNYWTL DPNCEKMFDN GNFRRKRKRK SESVGAGFDE DSNEDKKPLA
     LKSLGSDSPQ GASVLEQSSY DAAPEGKSKA PVGSAAQDSS HCFTNFASNM NALINNRTPR
     QFTAGRGDFS NSRHYLAELT SCPIPSPQIS APQTGSKVPC YPSKQQNNLC TSVMNPFGLN
     HLYSREGEV