ID   FXI2B_XENLA             Reviewed;         367 AA.
AC   Q63ZH2;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 2.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Forkhead box protein I2-B;
DE   AltName: Full=XlFoxI2-B;
GN   Name=foxi2-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAH82945.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte {ECO:0000312|EMBL:AAH82945.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Possible transcriptional activator. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH82945.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC082945; AAH82945.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001088107.1; NM_001094638.1.
DR   AlphaFoldDB; Q63ZH2; -.
DR   SMR; Q63ZH2; -.
DR   DNASU; 494806; -.
DR   GeneID; 494806; -.
DR   KEGG; xla:494806; -.
DR   CTD; 494806; -.
DR   Xenbase; XB-GENE-6255082; foxi2.L.
DR   OrthoDB; 1270467at2759; -.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Bgee; 494806; Expressed in blastula and 7 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..367
FT                   /note="Forkhead box protein I2-B"
FT                   /id="PRO_0000247729"
FT   DNA_BIND        124..218
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          31..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          224..254
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        224..241
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   367 AA;  40508 MW;  9EAB9C4ABC3D56B5 CRC64;
     MNTFGQQTSN PHAQDLLDMA KYYDHFNHYH QQQNQQLPQR PAAPPAPGYG LNEFSPPTAN
     PYLWLNGPAI NSSPYLNGGS GSPYFPTGYG GGQRQFLPPS SGFGVADFPW LSIPNQADLL
     KMVRPPYSYS SLIAMSIQNT PDKKLTLSQI YNYVAENFPF YKKSKAGWQN SIRHNLSLND
     CFKKVARDDN DPGKGNYWTL DPNCEKMFDN GNFRRKRKRK SEIVGAGFDE ESNEDKKPLA
     LKSLGPDSPG GASVVLEQSS YTAPEGKNKS PVGSVARDSS HCFTNFASNM NALINGRAPR
     QFSAGHGDFS NSRHYLAELA SCPISSPPIS EAQTKVACYP SKQQNSLCTS VLNPFSLNHV
     YSREGEV