ID   FXJ12_XENLA             Reviewed;         370 AA.
AC   Q32NH9;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Forkhead box protein J1.2;
DE            Short=FoxJ1.2;
GN   Name=foxj1.2 {ECO:0000250|UniProtKB:Q66IG8};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAI08617.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis {ECO:0000312|EMBL:AAI08617.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Key transcription factor required for motile ciliogenesis.
CC       Activates genes essential for motile cilia formation and function.
CC       {ECO:0000250|UniProtKB:Q708W2}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the FOXJ1 family. {ECO:0000305}.
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DR   EMBL; BC108616; AAI08617.1; -; mRNA.
DR   RefSeq; NP_001089890.1; NM_001096421.1.
DR   AlphaFoldDB; Q32NH9; -.
DR   SMR; Q32NH9; -.
DR   DNASU; 734957; -.
DR   GeneID; 734957; -.
DR   KEGG; xla:734957; -.
DR   CTD; 734957; -.
DR   Xenbase; XB-GENE-919747; foxj1.2.L.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 734957; Expressed in testis and 10 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; Cilium biogenesis/degradation; DNA-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..370
FT                   /note="Forkhead box protein J1.2"
FT                   /id="PRO_0000250445"
FT   DNA_BIND        108..202
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255, ECO:0000255|PROSITE-
FT                   ProRule:PRU00089"
FT   REGION          45..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          227..246
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   370 AA;  42037 MW;  FE6498F4CECD2239 CRC64;
     MPVLSTTHRL PLSVERERNR EDDSLTNLQW LQDFSILSTD LSSIANSRPP VPRVSQGPCS
     PPAGDTASCQ APRTGKQRVT VPTAWASLPT LSPSPVQEVD YRTNANVKPP YSYATLICMA
     MEASQQRKLT LSAIYNWITQ NFCYYRHADP SWQNSIRHNL SLNKCFMKVP RGKDEPGKGG
     FWQMDPRYAD MFVNGVLKRR RMPSSHLDPP RCNKTIGHHP YLPVSRPGSH HMQHISGGHR
     QSRRYEKPNP VLPAFRAPER QGDTLFTPED PLQGSNFDDL DLQAALISMC WEGDLAASNL
     NSTLTGNSGM DMNQQDPPMQ DNHWYLSTEG QQTWEQVKEE PVVEQWYSET GFVEDVLYEC
     PPWERVETLL