ID   FXJ12_XENTR             Reviewed;         371 AA.
AC   Q66IG8;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Forkhead box protein J1.2;
DE            Short=FoxJ1.2;
GN   Name=foxj1.2 {ECO:0000303|PubMed:16461016};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAH81355.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAH81355.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   TISSUE SPECIFICITY.
RX   PubMed=16461016; DOI=10.1016/j.modgep.2005.11.007;
RA   Choi V.M., Harland R.M., Khokha M.K.;
RT   "Developmental expression of FoxJ1.2, FoxJ2, and FoxQ1 in Xenopus
RT   tropicalis.";
RL   Gene Expr. Patterns 6:443-447(2006).
CC   -!- FUNCTION: Key transcription factor required for motile ciliogenesis.
CC       Activates genes essential for motile cilia formation and function.
CC       {ECO:0000250|UniProtKB:Q708W2}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed diffusely through much of gastrula and
CC       neurula stage embryos. At stage 23 (late neurula), limited to the otic
CC       vesicle. By stage 28 (tailbud), also expressed transiently in the
CC       presumptive nephrostomes of the pronephros. At stage 35 (early
CC       tadpole), expressed broadly in the head and strongly expressed in the
CC       developing gill structures. {ECO:0000269|PubMed:16461016}.
CC   -!- SIMILARITY: Belongs to the FOXJ1 family. {ECO:0000305}.
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DR   EMBL; BC081355; AAH81355.1; -; mRNA.
DR   RefSeq; NP_001008143.1; NM_001008142.2.
DR   AlphaFoldDB; Q66IG8; -.
DR   SMR; Q66IG8; -.
DR   STRING; 8364.ENSXETP00000029314; -.
DR   PaxDb; Q66IG8; -.
DR   DNASU; 493505; -.
DR   GeneID; 493505; -.
DR   KEGG; xtr:493505; -.
DR   CTD; 493505; -.
DR   Xenbase; XB-GENE-919738; foxj1.2.
DR   eggNOG; KOG2294; Eukaryota.
DR   HOGENOM; CLU_050055_0_0_1; -.
DR   InParanoid; Q66IG8; -.
DR   OMA; SSHHMQH; -.
DR   OrthoDB; 932495at2759; -.
DR   PhylomeDB; Q66IG8; -.
DR   TreeFam; TF333250; -.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000024431; Expressed in neurula embryo and 7 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; NAS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR   CDD; cd00059; FH; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; Cilium biogenesis/degradation; DNA-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..371
FT                   /note="Forkhead box protein J1.2"
FT                   /id="PRO_0000250446"
FT   DNA_BIND        109..203
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255, ECO:0000255|PROSITE-
FT                   ProRule:PRU00089"
FT   REGION          45..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          80..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          228..248
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        84..99
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   371 AA;  41890 MW;  0E709E9C3CE06DA7 CRC64;
     MPVLSTAHRL PLSVERDCSR EDDSLTNLQW LQDFSILSTD LSSIANSRPP LPRASQGPCS
     PPAGDTASCQ APRTGKQRSV AVPTAWASLP TPSPSPVQEV DYRTNANIKP PYSYATLICM
     AMEASQQRKL TLSAIYSWIT QNFCYYRHAD PSWQNSIRHN LSLNKCFMKV PRGKDEPGKG
     GFWQMDPRYA DMFVNGVLKR RRMPASHLDP PRCNKAIAHH PYLPVSRPSS HHMQHISGGH
     RQSRRYEKPN PVLPALRAPE RQGDALFTPE DPLQGSNFDD LDLQTALISM CWEGDLAASN
     LNSTLTGTSG MDMNLQDPPM QDNHWYLSTE GQQTWEQVKE EPVVEQWYNE TGFVEDVLYE
     CPPWERVETL L