FXJ1A_DANRE
ID FXJ1A_DANRE Reviewed; 458 AA.
AC F1QDF8; A8W994; B7SSI4; Q08CI2;
DT 29-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT 03-MAY-2011, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Forkhead box protein J1-A {ECO:0000305};
GN Name=foxj1a {ECO:0000312|ZFIN:ZDB-GENE-060929-1178};
GN Synonyms=foxj1 {ECO:0000303|PubMed:18956329};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=18956329; DOI=10.1387/ijdb.072477ea;
RA Aamar E., Dawid I.B.;
RT "Isolation and expression analysis of foxj1 and foxj1.2 in zebrafish
RT embryos.";
RL Int. J. Dev. Biol. 52:985-991(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=19011630; DOI=10.1038/ng.263;
RA Yu X., Ng C.P., Habacher H., Roy S.;
RT "Foxj1 transcription factors are master regulators of the motile ciliogenic
RT program.";
RL Nat. Genet. 40:1445-1453(2008).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis {ECO:0000312|EMBL:AAI24229.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=19011629; DOI=10.1038/ng.267;
RA Stubbs J.L., Oishi I., Izpisua Belmonte J.C., Kintner C.;
RT "The forkhead protein Foxj1 specifies node-like cilia in Xenopus and
RT zebrafish embryos.";
RL Nat. Genet. 40:1454-1460(2008).
RN [6]
RP DISRUPTION PHENOTYPE.
RX PubMed=19284996; DOI=10.1016/j.bbrc.2009.01.111;
RA Tian T., Zhao L., Zhang M., Zhao X., Meng A.;
RT "Both foxj1a and foxj1b are implicated in left-right asymmetric development
RT in zebrafish embryos.";
RL Biochem. Biophys. Res. Commun. 380:537-542(2009).
RN [7]
RP FUNCTION, AND INDUCTION.
RX PubMed=20937855; DOI=10.1073/pnas.1005998107;
RA Hellman N.E., Liu Y., Merkel E., Austin C., Le Corre S., Beier D.R.,
RA Sun Z., Sharma N., Yoder B.K., Drummond I.A.;
RT "The zebrafish foxj1a transcription factor regulates cilia function in
RT response to injury and epithelial stretch.";
RL Proc. Natl. Acad. Sci. U.S.A. 107:18499-18504(2010).
CC -!- FUNCTION: Key transcription factor required for motile ciliogenesis.
CC Activates genes essential for motile cilia formation and function. Its
CC activity is sufficient for ectopic development of cilia that resemble
CC motile cilia. {ECO:0000269|PubMed:19011629,
CC ECO:0000269|PubMed:19011630, ECO:0000269|PubMed:20937855}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
CC -!- TISSUE SPECIFICITY: Expressed in floor plate, dorsal forerunner cells,
CC Kupffers vesicle, the floor plate, pronephric ducts and kidney.
CC {ECO:0000269|PubMed:18956329, ECO:0000269|PubMed:19011629,
CC ECO:0000269|PubMed:19011630}.
CC -!- INDUCTION: By hedgehog signaling in the floor plate. In response to
CC injury and stretch. {ECO:0000269|PubMed:19011630,
CC ECO:0000269|PubMed:20937855}.
CC -!- DISRUPTION PHENOTYPE: Randomization of the left-right body.
CC {ECO:0000269|PubMed:19011629, ECO:0000269|PubMed:19284996}.
CC -!- SIMILARITY: Belongs to the FOXJ1 family. {ECO:0000305}.
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DR EMBL; EU201184; ABW82682.1; -; mRNA.
DR EMBL; EU599363; ACF15248.1; -; mRNA.
DR EMBL; CABZ01077367; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC124228; AAI24229.1; -; mRNA.
DR EMBL; BC164538; AAI64538.1; -; mRNA.
DR RefSeq; NP_001070174.2; NM_001076706.2.
DR AlphaFoldDB; F1QDF8; -.
DR SMR; F1QDF8; -.
DR STRING; 7955.ENSDARP00000077301; -.
DR PaxDb; F1QDF8; -.
DR Ensembl; ENSDART00000157772; ENSDARP00000134207; ENSDARG00000101919.
DR Ensembl; ENSDART00000168280; ENSDARP00000132873; ENSDARG00000101919.
DR GeneID; 767737; -.
DR KEGG; dre:767737; -.
DR CTD; 767737; -.
DR ZFIN; ZDB-GENE-060929-1178; foxj1a.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000156895; -.
DR HOGENOM; CLU_050055_0_0_1; -.
DR InParanoid; F1QDF8; -.
DR OMA; FKKRRMP; -.
DR OrthoDB; 1270467at2759; -.
DR PhylomeDB; F1QDF8; -.
DR TreeFam; TF333250; -.
DR PRO; PR:F1QDF8; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 3.
DR Bgee; ENSDARG00000101919; Expressed in testis and 50 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:ZFIN.
DR GO; GO:0090660; P:cerebrospinal fluid circulation; IMP:ZFIN.
DR GO; GO:0060271; P:cilium assembly; IDA:ZFIN.
DR GO; GO:0007368; P:determination of left/right symmetry; IMP:ZFIN.
DR GO; GO:0003351; P:epithelial cilium movement involved in extracellular fluid movement; IMP:ZFIN.
DR GO; GO:0003146; P:heart jogging; IMP:ZFIN.
DR GO; GO:0001947; P:heart looping; IMP:ZFIN.
DR GO; GO:0070121; P:Kupffer's vesicle development; TAS:ZFIN.
DR GO; GO:0060296; P:regulation of cilium beat frequency involved in ciliary motility; IMP:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0009611; P:response to wounding; IMP:ZFIN.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW Activator; Cilium biogenesis/degradation; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..458
FT /note="Forkhead box protein J1-A"
FT /id="PRO_0000430814"
FT DNA_BIND 142..236
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 68..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 305..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 188
FT /note="N -> S (in Ref. 4; AAI24229/AAI64538)"
FT CONFLICT 229
FT /note="G -> E (in Ref. 1; ABW82682)"
FT CONFLICT 250
FT /note="R -> T (in Ref. 2; ACF15248)"
FT CONFLICT 258
FT /note="V -> I (in Ref. 2; ACF15248 and 4; AAI24229/
FT AAI64538)"
FT CONFLICT 281
FT /note="S -> N (in Ref. 4; AAI24229/AAI64538)"
FT CONFLICT 312
FT /note="Y -> H (in Ref. 2; ACF15248 and 4; AAI24229/
FT AAI64538)"
SQ SEQUENCE 458 AA; 50720 MW; 400BEA001E48B486 CRC64;
MLSMSSMDPW PEGSVGLEEE VVTAAAQAER LDTSTPLQCN TSLDSDNLDD SLTSLQWLQE
FSILNASTGQ HTSPSSHSHL MGSDAPSSPL AGDPASIGMP LTPGKPTAAS FCRVPMFSAL
PSLVAHGHCP DEVDYKSNPH IKPPYSYATL ICMAMQASKK TKITLSCIYK WITDNFCYFR
HADPTWQNSI RHNLSLNKCF IKVPRQKDEP GKGGFWKIDP QYAERLLNGA YKKRRLPPVQ
INPALQHRLR MNAQATGVIS RNLSVSPESQ QLLKDFEEAT SADQNWDPRL AEATMLSCWI
SGKGTNKRKQ PYNHRTGKTP RRSSSPLLVM DEQEDLSSLR GNFDWDALLD SALNGELSLN
EGSPLSPTPQ DEELMIRGTH ISPQEAPVEN HVLMETQRSG DEDFDEETFL ATAFLQSPWS
EVDESNRSDF LGSSTVSIDQ LFDLSFGGDL SSKIETLL
